Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Rene J. McLaughlin"'
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Human islets and dendritic cells generate post-translationally modified islet autoantigens
Autor: E. J. P. de Koning, A.H. de Ru, P.A. van Veelen, A de Haan, Bart O. Roep, Rene J. Mclaughlin, M van Lummel, Arnaud Zaldumbide
Publikováno v: Clinical and Experimental Immunology, 185(2), 133-140
Clinical & Experimental Immunology. Wiley-Blackwell
Summary The initiation of type 1 diabetes (T1D) requires a break in peripheral tolerance. New insights into neoepitope formation indicate that post-translational modification of islet autoantigens, for example via deamidation, may be an important com
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0efb039c846658343408da04777e2f6f
https://doi.org/10.1111/cei.12775
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3
Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis
Autor: Jermaine Goveia, Lin Lin, Geert Carmeliet, Dena Panovska, Andreas Pircher, Lena-Christin Conradi, Yizhi Liu, Lars Bolund, Stefan Vinckier, Liliana Sokol, Kim D. Falkenberg, Katerina Rohlenova, Guy Eelen, Tine Van Bergen, Huanming Yang, Rene J. Mclaughlin, Mieke Dewerchin, Abhishek Subramanian, Bernard Thienpont, Nadine Ectors, Tobias K. Karakach, Yonglun Luo, Lucas Treps, Jian Wang, Frank J. T. Staal, Joanna Kalucka, Shawez Khan, Xuri Li, Peter Carmeliet, Yingfeng Zheng, Luc Schoonjans, Laura P.M.H. de Rooij, Patrik De Haes, Melissa García-Caballero, Frederik De Smet, Laure-Anne Teuwen, Federico Taverna, Vincent Geldhof, Steve Stegen
Publikováno v: Rohlenova, K, Goveia, J, García-Caballero, M, Subramanian, A, Kalucka, J, Treps, L, Falkenberg, K D, de Rooij, L P M H, Zheng, Y, Lin, L, Sokol, L, Teuwen, L-A, Geldhof, V, Taverna, F, Pircher, A, Conradi, L-C, Khan, S, Stegen, S, Panovska, D, De Smet, F, Staal, F J T, Mclaughlin, R J, Vinckier, S, Van Bergen, T, Ectors, N, De Haes, P, Wang, J, Bolund, L, Schoonjans, L, Karakach, T K, Yang, H, Carmeliet, G, Liu, Y, Thienpont, B, Dewerchin, M, Eelen, G, Li, X, Luo, Y & Carmeliet, P 2020, ' Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis ', Cell Metabolism, vol. 31, no. 4, pp. 862-877.e14 . https://doi.org/10.1016/j.cmet.2020.03.009
Cell Metabolism, 31(4), 862-877.e14. CELL PRESS
Cell metabolism
Cell Metabolism
Endothelial cell (EC) metabolism is an emerging target for anti-angiogenic therapy in tumor angiogenesis and choroidal neovascularization (CNV), but little is known about individual EC metabolic transcriptomes. By single-cell RNA sequencing 28,337 mu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b2f5df47885e409e283717683a15d4
https://doi.org/10.1016/j.cmet.2020.03.009
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4
An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates
Autor: Albert Wolthuis, Diether Lambrechts, Xavier Sagaert, Wouter Everaerts, Junbin Qian, Yingfeng Zheng, Johan Vansteenkiste, Guy Eelen, Luc Schoonjans, Lena-Christin Conradi, Herbert Decaluwé, Alexander Emmert, Stefan Vinckier, Erik Verbeken, Paul De Leyn, Lin Lin, Shawez Khan, Birgit Weynand, Mieke Dewerchin, Lucas Treps, Liliana Sokol, Baki Topal, Bernard Thienpont, Frank J. T. Staal, Rene J. Mclaughlin, Melissa García-Caballero, Jian Wang, Federico Taverna, Peter Carmeliet, Lars Bolund, Dena Panovska, Andreas Pircher, Laure-Anne Teuwen, Yonglun Luo, Huanming Yang, Els Wauters, Joanna Kalucka, Vincent Geldhof, Francis Impens, Jermaine Goveia, Hanibal Bohnenberger, Bram Boeckx, Massimiliano Mazzone, Frederik De Smet, Vincenzo Lagani, Xuri Li, Tobias K. Karakach, Laura P.M.H. de Rooij, Katerina Rohlenova
Publikováno v: Goveia, J, Rohlenova, K, Taverna, F, Treps, L, Conradi, L-C, Pircher, A, Geldhof, V, de Rooij, L P M H, Kalucka, J, Sokol, L, García-Caballero, M, Zheng, Y, Qian, J, Teuwen, L-A, Khan, S, Boeckx, B, Wauters, E, Decaluwé, H, De Leyn, P, Vansteenkiste, J, Weynand, B, Sagaert, X, Verbeken, E, Wolthuis, A, Topal, B, Everaert, W, Bohnenberger, H, Emmert, A, Panovska, D, De Smet, F, Staal, F J T, Mclaughlin, R J, Impens, F, Lagani, V, Vinckier, S, Mazzone, M, Schoonjans, L, Dewerchin, M, Eelen, G, Karakach, T K, Yang, H, Wang, J, Bolund, L, Lin, L, Thienpont, B, Li, X, Lambrechts, D, Luo, Y & Carmeliet, P 2020, ' An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates ', Cancer Cell, vol. 37, no. 1, pp. 21-36.e13 . https://doi.org/10.1016/j.ccell.2019.12.001
Cancer Cell
Cancer Cell, 37(1), 21-36.e13. CELL PRESS
Heterogeneity of lung tumor endothelial cell (TEC) phenotypes across patients, species (human/mouse), and models (in vivo/in vitro) remains poorly inventoried at the single-cell level. We single-cell RNA (scRNA)-sequenced 56,771 endothelial cells fro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a8902654d06bbf401b9e1610520c8a
https://doi.org/10.1016/j.ccell.2019.12.001
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5
Where, How, and When: Positioning Posttranslational Modification Within Type 1 Diabetes Pathogenesis
Autor: Menno van Lummel, Bart O. Roep, Rene J. Mclaughlin, Matthew P. Spindler
Publikováno v: Current Diabetes Reports
Current Diabetes Reports, 16(7)
Autoreactive T cells specific for islet autoantigens develop in type 1 diabetes (T1D) by escaping central as well as peripheral tolerance. The current paradigm for development of islet autoimmunity is just beginning to include the contribution of pos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9ba30ffd8513f42a0916346ac1b770b
https://doi.org/10.1007/s11892-016-0752-4
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6
Hyperuricaemia elevates circulating CCL2 levels and primes monocyte trafficking in subjects with inter-critical gout
Autor: Rene J. McLaughlin, Andrew A. Harrison, Rebecca Grainger, Jacquie L. Harper
Publikováno v: Rheumatology (Oxford, England). 52(6)
Objective. To investigate the effect of hyperuricaemia on serum chemokine (C-C motif) ligand 2 (CCL2) levels and blood monocytes in people with gout. Methods. Whole blood was collected from subjects with a history of acute or chronic gout but not cur
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78dbc39b24b1a72bf2453d47e173c213
https://pubmed.ncbi.nlm.nih.gov/23413026
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7
Long-chain lipids are required for the innate immune recognition of trehalose diesters by macrophages
Autor: Ashna A. Khan, Faustin Kamena, Rene J. McLaughlin, Bridget L. Stocker, Stephanie H. Chee, Jacquie L. Harper, Mattie S. M. Timmer
Publikováno v: Chembiochem : a European journal of chemical biology. 12(17)
Going to any length? Trehalose diesters of various chain lengths have been synthesised in order to determine the effect of lipid length on innate immune recognition, as determined by NO and cytokine production by macrophages. In this work, we show th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7517a24a4c0e7b733fa4bab4136e98dd
https://pubmed.ncbi.nlm.nih.gov/21990105
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8
A functional extracellular matrix biomaterial derived from ovine forestomach
Autor: Evan Floden, Madhusudan Vasudevamurthy, Rene J. McLaughlin, Neil J. Fisher, Brian Roderick Ward, Sandi G. Dempsey, Barnaby C. H. May, Sharleen M. Irvine, Stan Lun, Leonardo Negron, Keryn Dallas Johnson
Publikováno v: Biomaterials. 31(16)
Extracellular matrix (ECM) based biomaterials have an established place as medical devices for wound healing and tissue regeneration. In the search for biomaterials we have identified ovine forestomach matrix (OFM), a thick, large format ECM which is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1384773042e21717a8bcb969e1683f44
https://pubmed.ncbi.nlm.nih.gov/20226520
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