Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Rene Holm"'
Autor:
Kristin, Forner, René, Holm, Boontida, Morakul, Buraphacheep, Junyaprasert Varaporn, Maximilian, Ackermann, Johanna, Mazur, Peter, Langguth
Publikováno v:
In European Journal of Pharmaceutical Sciences 1 April 2017 101:211-219
Autor:
Janine Wilkinson, Damilola Ajulo, Valeria Tamburrini, Gwenaelle Le Gall, Kristof Kimpe, Rene Holm, Peter Belton, Sheng Qi
Long acting injectables (LAI) have received increased research and commercial interest due to their potential for improving treatment effectiveness and adherence for antipsychotic, antiviral and addiction treatments. A range of materials have been us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efbe99806e72ae54a22dec778fb3b5b0
https://ueaeprints.uea.ac.uk/id/eprint/85955/
https://ueaeprints.uea.ac.uk/id/eprint/85955/
Autor:
Sarah Lindsay, Olympia Tumolva, Tatsiana Khamiakova, Hans Coppenolle, Martin Kovarik, Sanket Shah, René Holm, Yvonne Perrie
Publikováno v:
Pharmaceutics, Vol 16, Iss 9, p 1159 (2024)
Microfluidic liposome production presents a streamlined pathway for expediting the translation of liposomal formulations from the laboratory setting to clinical applications. Using this production method, resultant liposome characteristics can be tun
Externí odkaz:
https://doaj.org/article/9ef5e5d2ecb748f3b94b701c41824cd0
Autor:
Patrick J, O'Dwyer, Karl J, Box, Niklas J, Koehl, Harriet, Bennett-Lenane, Christos, Reppas, Rene, Holm, Martin, Kuentz, Brendan T, Griffin
Publikováno v:
Molecular pharmaceutics. 17(9)
The absence of an intestinal absorption sink is a significant weakness of standard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8453dee903d030d02f453f36e06421fd
https://pubmed.ncbi.nlm.nih.gov/32787274
https://pubmed.ncbi.nlm.nih.gov/32787274
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1909 (2023)
Dissolution limitations to oral absorption can occur if the time required for dissolution is longer than the transit time across the small intestine and/or if dissolution is slower than the drug’s permeation through the gut wall. These limitations
Externí odkaz:
https://doaj.org/article/f6ffb8b65cfb4371bf4d03ce21b50a2a
Autor:
Rasmus Blaaholm Nielsen, René Holm, Ils Pijpers, Jan Snoeys, Ulla Gro Nielsen, Carsten Uhd Nielsen
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 283 (2023)
P-glycoprotein (P-gp) limits the oral absorption of drug substances. Potent small molecule P-gp inhibitors (e.g., zosuquidar) and nonionic surfactants (e.g., polysorbate 20) inhibit P-gp by proposedly different mechanisms. Therefore, it was hypothesi
Externí odkaz:
https://doaj.org/article/a46f314b76934509a5e5f8a426054059
Autor:
Rasmus Blaaholm Nielsen, René Holm, Ils Pijpers, Jan Snoeys, Ulla Gro Nielsen, Carsten Uhd Nielsen
Publikováno v:
International Journal of Pharmaceutics: X, Vol 3, Iss , Pp 100089- (2021)
P-glycoprotein inhibitors, like zosuquidar, have widely been used to study the role of P-glycoprotein in oral absorption. Still, systematic studies on the inhibitor dose-response relationship on intestinal drug permeation are lacking. In the present
Externí odkaz:
https://doaj.org/article/a7a961e60a9f42388fa54a007c5b264b
Publikováno v:
FEBS Open Bio, Vol 9, Iss 6, Pp 1071-1081 (2019)
Nuclear factor of activated T cells 5 (NFAT5) is a transcription factor involved in the regulation of several genes involved in the response to extracellular hyperosmolality. Recently, the uptake of ibuprofen by an as yet unknown carrier was suggeste
Externí odkaz:
https://doaj.org/article/c85ba85a8bab4f54ac31d4beb8a8c5d8
Autor:
Fiona Macintyre, Hanu Ramachandruni, Jeremy N. Burrows, René Holm, Anna Thomas, Jörg J. Möhrle, Stephan Duparc, Rob Hooft van Huijsduijnen, Brian Greenwood, Winston E. Gutteridge, Timothy N. C. Wells, Wiweka Kaszubska
Publikováno v:
Malaria Journal, Vol 17, Iss 1, Pp 1-18 (2018)
Abstract Over the last 15 years, the majority of malaria drug discovery and development efforts have focused on new molecules and regimens to treat patients with uncomplicated or severe disease. In addition, a number of new molecular scaffolds have b
Externí odkaz:
https://doaj.org/article/dbdcceb481fa497fa620c83328de23ba
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 13, Iss 6, Pp 507-517 (2018)
Parkinson's disease (PD) is a chronic debilitating disease affecting approximately 1% of the population over the age of 60. The severity of PD is correlated to the degree of dopaminergic neuronal loss. Apomorphine has a similar chemical structure as
Externí odkaz:
https://doaj.org/article/53e04430893b45ce95f35101a19d6852