Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Rene Hersperger"'
Autor:
Marc Bigaud, Zuhal Dincer, Birgit Bollbuck, Janet Dawson, Nicolau Beckmann, Christian Beerli, Gina Fishli-Cavelti, Michaela Nahler, Daniela Angst, Philipp Janser, Heike Otto, Elisabeth Rosner, Rene Hersperger, Christian Bruns, Jean Quancard
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168252 (2016)
Homeostasis of vascular barriers depends upon sphingosine 1-phosphate (S1P) signaling via the S1P1 receptor. Accordingly, S1P1 competitive antagonism is known to reduce vascular barrier integrity with still unclear pathophysiological consequences. Th
Externí odkaz:
https://doaj.org/article/d21025381568439f81e9c5673c237ad7
Autor:
Roland Feifel, Ernst Blum, Richard Heng, Achim Schlapbach, Juraj Velcicky, Daniel Pflieger, Laszlo Revesz, Stuart Hawtin, Rene Hersperger, Christine Huppertz
Publikováno v:
ACS Medicinal Chemistry Letters. 9:392-396
[Image: see text] MAP-activated protein kinase 2 (MK2) plays an important role in the regulation of innate immune response as well as in cell survival upon DNA damage. Despite its potential for the treatment of inflammation and cancer, to date no MK2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf9d762d801fcd1e9dbcf6f7a5780a5
https://doi.org/10.1021/acsmedchemlett.8b00098
https://doi.org/10.1021/acsmedchemlett.8b00098
Autor:
Jayachandran N. Kizhakkedathu, Joerg Eder, Theo Klein, Paul Erbel, Sohyeong Kang, Frederic Villard, Rosa Viner, Frédéric Bornancin, Christopher M. Overall, Martin Renatus, Jean Quancard, Rene Hersperger, Jutta Blank, John J. Priatel, Michael Blank, Achim Schlapbach, Shan-Yu Fung, Stuart E. Turvey, Laura Israel, Nicola Hughes
Publikováno v:
Nature Chemical Biology, 15(3), 304-+. Nature Publishing Group
MALT1 paracaspase is central for lymphocyte antigen-dependent responses including NF-κB activation. We discovered nanomolar, selective allosteric inhibitors of MALT1 that bind by displacing the side chain of Trp580, locking the protease in an inacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055231059694d2a49af944d4ec994f9e
https://pure.eur.nl/en/publications/b973dccf-2476-4ae6-a1e4-93afb9315728
https://pure.eur.nl/en/publications/b973dccf-2476-4ae6-a1e4-93afb9315728
Autor:
Daniela Angst, Nicolau Beckmann, Christian Bruns, Philipp Janser, Heike Otto, Jean Quancard, Marc Bigaud, Elisabeth Rosner, Birgit Bollbuck, Gina Fishli-Cavelti, Christian Beerli, Zuhal Dincer, Rene Hersperger, Michaela Nahler, Janet Dawson
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168252 (2016)
PLoS ONE
PLoS ONE
Rational Homeostasis of vascular barriers depends upon sphingosine 1-phosphate (S1P) signaling via the S1P1 receptor. Accordingly, S1P1 competitive antagonism is known to reduce vascular barrier integrity with still unclear pathophysiological consequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9efb32950a8fc714d76e94ffb92b371
http://europepmc.org/articles/PMC5179015?pdf=render
http://europepmc.org/articles/PMC5179015?pdf=render
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 301:241-248
We investigated the pharmacology of a new class of phosphodiesterase 4 (PDE4) inhibitor, 6,8-disubstituted 1,7-naphthyridines, by using 4-(8-benzo[1,2,5]oxadiazol-5-yl-[1,7]naphthyridin-6-yl)-benzoic acid (NVP-ABE171) as a representative compound and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8686835269c0a7aeb2aded5913e138af
https://doi.org/10.1124/jpet.301.1.241
https://doi.org/10.1124/jpet.301.1.241
Autor:
Lukas Oberer, Birgit Bollbuck, Frederic Bassilana, Peter Buehlmayer, Frederic Berst, Markus Streiff, Charles Pally, Christian Beerli, Rene Hersperger, Christian Bruns, Philipp Janser, Jean Quancard, Daniela Angst
Publikováno v:
Journal of medicinal chemistry. 55(22)
A prodrug approach to optimize the oral exposure of a series of sphingosine 1-phosphate receptor 1 (S1P(1)) antagonists for chronic efficacy studies led to the discovery of (S)-2-{[3'-(4-chloro-2,5-dimethylphenylsulfonylamino)-3,5-dimethylbiphenyl-4-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2c76607f1881583858e4173829ead6
https://pubmed.ncbi.nlm.nih.gov/23067318
https://pubmed.ncbi.nlm.nih.gov/23067318
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:233-235
The synthesis of a 6,8-disubstituted 1,7-naphthyridine 1 and its characterization as a potent and selective phosphodiesterase type 4D inhibitor (IC50=1.5nM) are described. The compound inhibited TNFα-release from human peripheral blood mononuclear c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6166875be641491e22b24349b5e3bdd
https://doi.org/10.1016/s0960-894x(01)00720-x
https://doi.org/10.1016/s0960-894x(01)00720-x
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5af6358680bb5f11d095eb597e7dd00
https://doi.org/10.1002/chin.199920224
https://doi.org/10.1002/chin.199920224
Publikováno v:
ChemInform. 31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5ae5f63fa3c3d5a9f673a51421a110c
https://doi.org/10.1002/chin.200023144
https://doi.org/10.1002/chin.200023144
Autor:
Roland Feifel, Achim Schlapbach, Thomas Buhl, Laszlo Revesz, Christian Bruns, Hans-Günter Zerwes, Philipp Janser, Rudolf Waelchli, Birgit Bollbuck, Rene Hersperger, Jörg Eder
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(1)
The design, synthesis, and the biological evaluation of 2-benzamido-pyrimidines as novel IKK inhibitors are described. By optimization of the lead compound 3, compounds 16 and 24 are identified as good inhibitors of IKK2 with IC(50) values of 40 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ece4937cf28364d74f5b50e9da225263
https://pubmed.ncbi.nlm.nih.gov/16236504
https://pubmed.ncbi.nlm.nih.gov/16236504