Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Rene H Medema"'
Autor:
Ziva Pogacar, Jackie L Johnson, Lenno Krenning, Giulia De Conti, Fleur Jochems, Cor Lieftink, Arno Velds, Leyma Wardak, Kelvin Groot, Arnout Schepers, Liqin Wang, Ji-Ying Song, Marieke van de Ven, Olaf van Tellingen, Rene H Medema, Roderick L Beijersbergen, Rene Bernards, Rodrigo Leite de Oliveira
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0273182 (2022)
Inducing senescence in cancer cells is emerging as a new therapeutic strategy. In order to find ways to enhance senescence induction by palbociclib, a CDK4/6 inhibitor approved for treatment of metastatic breast cancer, we performed functional geneti
Externí odkaz:
https://doaj.org/article/6f29ef7b9b734b128186d1949fb65c09
Autor:
Sander G Basten, Erica E Davis, Ad J M Gillis, Ellen van Rooijen, Hans Stoop, Nikolina Babala, Ive Logister, Zachary G Heath, Trudy N Jonges, Nicholas Katsanis, Emile E Voest, Freek J van Eeden, Rene H Medema, René F Ketting, Stefan Schulte-Merker, Leendert H J Looijenga, Rachel H Giles
Publikováno v:
PLoS Genetics, Vol 9, Iss 4, p e1003384 (2013)
Seminoma is a subclass of human testicular germ cell tumors (TGCT), the most frequently observed cancer in young men with a rising incidence. Here we describe the identification of a novel gene predisposing specifically to seminoma formation in a ver
Externí odkaz:
https://doaj.org/article/74c319b0e6ea4343a061201f9bdccff2
Autor:
Eric Solary, Patricia Blanc, Michael Boutros, Charis Girvalaki, Franco Locatelli, Rene H. Medema, Péter Nagy, Josep Tabernero
Publikováno v:
Cancer Discovery. 12:2504-2508
Summary: “UNCAN.eu” refers to a collective European effort seeking to enable a leap forward in our understanding of cancer. This initiative, which includes the creation of a European cancer research data hub, will pave the way to new advances in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3abb0bd7d7871d43fb67de2f7482fac2
https://doi.org/10.1158/2159-8290.cd-22-0970
https://doi.org/10.1158/2159-8290.cd-22-0970
Autor:
Jukka Westermarck, Goutham Narla, Karin de Visser, Emilia Peuhu, Heikki Joensuu, Rene H. Medema, Krister Wennerberg, Jochen Maurer, Laura L. Elo, Pauliina Kronqvist, Denise C. Connolly, Karolina Pavic, Xi Qiao, Harri Sihto, Sofia Khan, Prson Gautam, Tove J. Grönroos, Femke M. Feringa, Julia P. Vainonen, Anna N. Cvrljevic, Umar Butt, Caroline Farrington, Srikar G. Nagelli, Anni Laine
Basal-like breast cancers (BLBC) are characterized by defects in homologous recombination (HR), deficient mitotic checkpoint, and high-proliferation activity. Here, we discover CIP2A as a candidate driver of BLBC. CIP2A was essential for DNA damage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58953009a86d62cede066667426b4c40
https://doi.org/10.1158/0008-5472.c.6513027
https://doi.org/10.1158/0008-5472.c.6513027
Autor:
Jukka Westermarck, Goutham Narla, Karin de Visser, Emilia Peuhu, Heikki Joensuu, Rene H. Medema, Krister Wennerberg, Jochen Maurer, Laura L. Elo, Pauliina Kronqvist, Denise C. Connolly, Karolina Pavic, Xi Qiao, Harri Sihto, Sofia Khan, Prson Gautam, Tove J. Grönroos, Femke M. Feringa, Julia P. Vainonen, Anna N. Cvrljevic, Umar Butt, Caroline Farrington, Srikar G. Nagelli, Anni Laine
Supplementary Data from CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1885b41a24ffb845f2d6700db7ba978f
https://doi.org/10.1158/0008-5472.22428465
https://doi.org/10.1158/0008-5472.22428465
Autor:
Matheus Henrique Dias, Anoek Friskes, Siying Wang, Joao M. Fernandes Neto, Frank van Gemert, Soufiane Mourragui, Hendrik J. Kuiken, Sara Mainardi, Daniel Alvarez-Villanueva, Cor Lieftink, Ben Morris, Anna Dekker, Emma van Dijk, Chrysa Papagianni, Marcelo S. da Silva, Robin Jansen, Antonio Mulero-Sánchez, Elke Malzer, August Vidal, Cristina Santos, Ramón Salazar, Rosangela A. M. Wailemann, Thompson E. P. Torres, Giulia De Conti, Jonne A. Raaijmakers, Petur Snaebjornsson, Shengxian Yuan, Wenxin Qin, John S. Kovach, Hugo A. Armelin, Hein te Riele, Alexander van Oudenaarden, Haojie Jin, Roderick L. Beijersbergen, Alberto Villanueva, Rene H. Medema, Rene Bernards
Cancer homeostasis depends on a balance between activated oncogenic pathways driving tumorigenesis and engagement of stress-response programs that counteract the inherent toxicity of such aberrant signaling. While inhibition of oncogenic signaling pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a1e3875a49631c0a488ddbe547c772b
https://doi.org/10.1101/2023.02.06.527335
https://doi.org/10.1101/2023.02.06.527335
Autor:
Dorine C Hintzen, Mar Soto, Michael Schubert, Bjorn Bakker, Diana C J Spierings, Karoly Szuhai, Peter M Lansdorp, Roel J C Kluin, Floris Foijer, René H Medema, Jonne A Raaijmakers
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0268579 (2022)
Aneuploidy and chromosomal instability are both commonly found in cancer. Chromosomal instability leads to karyotype heterogeneity in tumors and is associated with therapy resistance, metastasis and poor prognosis. It has been hypothesized that aneup
Externí odkaz:
https://doaj.org/article/f584554feac24a5684cb7d0cfee58281
Publikováno v:
Frontiers in Oncology, Vol 3 (2013)
FoxM1 is a member of the forkhead family of transcription factors. Since its identification 15 year ago, numerous studies have progressively contributed to our current understanding on FoxM1 functions. Early work showed that FoxM1 regulates the trans
Externí odkaz:
https://doaj.org/article/58f40f0f464f4d0b86d3ad4f745d92ea
Autor:
Daniël Splinter, Marvin E Tanenbaum, Arne Lindqvist, Dick Jaarsma, Annette Flotho, Ka Lou Yu, Ilya Grigoriev, Dieuwke Engelsma, Elize D Haasdijk, Nanda Keijzer, Jeroen Demmers, Maarten Fornerod, Frauke Melchior, Casper C Hoogenraad, René H Medema, Anna Akhmanova
Publikováno v:
PLoS Biology, Vol 8, Iss 4, p e1000350 (2010)
BICD2 is one of the two mammalian homologues of the Drosophila Bicaudal D, an evolutionarily conserved adaptor between microtubule motors and their cargo that was previously shown to link vesicles and mRNP complexes to the dynein motor. Here, we iden
Externí odkaz:
https://doaj.org/article/10400eedc65345748f1c28fcffc7b328
Autor:
Renske van Leuken, Linda Clijsters, Wouter van Zon, Dan Lim, XueBiao Yao, Rob M F Wolthuis, Michael B Yaffe, René H Medema, Marcel A T M van Vugt
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5282 (2009)
Polo-like kinase-1 (Plk1) is activated before mitosis by Aurora A and its cofactor Bora. In mitosis, Bora is degraded in a manner dependent on Plk1 kinase activity and the E3 ubiquitin ligase SCF-betaTrCP. Here, we show that Plk1 is also required for
Externí odkaz:
https://doaj.org/article/5bdd7095f17b43e5addb2cbe505d25b1