Common variants in glyoxalase I do not increase chronic pancreatitis risk.

Autor: Tom Kaune, Marcus Hollenbach, Bettina Keil, Jian-Min Chen, Emmanuelle Masson, Carla Becker, Marko Damm, Claudia Ruffert, Robert Grützmann, Albrecht Hoffmeister, Rene H M Te Morsche, Giulia Martina Cavestro, Raffaella Alessia Zuppardo, Adrian Saftoiu, Ewa Malecka-Panas, Stanislaw Głuszek, Peter Bugert, Markus M Lerch, Frank Ulrich Weiss, Wen-Bin Zou, Zhuan Liao, Peter Hegyi, Joost Ph Drenth, Jan Riedel, Claude Férec, Markus Scholz, Holger Kirsten, Andrea Tóth, Maren Ewers, Heiko Witt, Heidi Griesmann, Patrick Michl, Jonas Rosendahl

Publikováno v: PLoS ONE, Vol 14, Iss 10, p e0222927 (2019)

INTRODUCTION:Chronic pancreatitis (CP) may be caused by oxidative stress. An important source of reactive oxygen species (ROS) is the methylglyoxal-derived formation of advanced glycation endproducts (AGE). Methylglyoxal is detoxified by Glyoxalase I

Externí odkaz: https://doaj.org/article/0b1930c4b69842dcaa5299eec41f9046

Droplet digital polymerase chain reaction for rapid broad‐spectrum detection of bloodstream infections

Autor: Geert J. A. Wanten, Daisy Dalloyaux, Heiman F. L. Wertheim, Chantal P. Bleeker-Rovers, Anke Christenhusz, Hennie M.J. Roelofs, Yannick Wouters, Rene H. M. te Morsche

Publikováno v: Microbial Biotechnology, 13(3), 657-668. Wiley
Microbial Biotechnology
Microbial Biotechnology, 13, 657-668
Microbial Biotechnology, 13, 3, pp. 657-668
Microbial Biotechnology, Vol 13, Iss 3, Pp 657-668 (2020)

Summary The droplet digital polymerase chain reaction (ddPCR) is a novel molecular technique that allows rapid quantification of rare target DNA sequences. Aim of this study was to explore the feasibility of the ddPCR technique to detect pathogen DNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef06df15e93027a805deb37a4398bf25
https://doi.org/10.1111/1751-7915.13491

The functional -765G→C polymorphism of the COX-2 gene may reduce the risk of developing crohn's disease.

Autor: Hilbert S de Vries, Rene H M te Morsche, Martijn G H van Oijen, Iris D Nagtegaal, Wilbert H M Peters, Dirk J de Jong

Publikováno v: PLoS ONE, Vol 5, Iss 11, p e15011 (2010)

BackgroundCyclooxygenase-2 (COX-2) is a key enzyme involved in the conversion of arachidonic acid into prostaglandins. COX-2 is mainly induced at sites of inflammation in response to proinflammatory cytokines such as interleukin-1α/β, interferon-γ

Externí odkaz: https://doaj.org/article/70f4f6a05b2f4637b3efa9d081aae634

Pasireotide does not improve efficacy of aspiration sclerotherapy in patients with large hepatic cysts, a randomized controlled trial

Autor: Tom J. G. Gevers, Leo J. Schultze Kool, Titus F. M. Wijnands, Joost P.H. Drenth, Marten A Lantinga, Rene H. M. te Morsche

Publikováno v: European Radiology, 28, 6, pp. 2682-2689
European Radiology
European Radiology, 28, 2682-2689

Objectives We tested whether complementary use of the somatostatin analogue pasireotide would augment efficacy of aspiration sclerotherapy of hepatic cysts. Methods We conducted a double-blind, placebo-controlled trial in patients who underwent aspir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3751756b62815fe51427bdabf5790daf
https://hdl.handle.net/2066/191334

Genome-wide association study identifies inversion in the

Autor: Jonas, Rosendahl, Holger, Kirsten, Eszter, Hegyi, Peter, Kovacs, Frank Ulrich, Weiss, Helmut, Laumen, Peter, Lichtner, Claudia, Ruffert, Jian-Min, Chen, Emmanuelle, Masson, Sebastian, Beer, Constantin, Zimmer, Katharina, Seltsam, Hana, Algül, Florence, Bühler, Marco J, Bruno, Peter, Bugert, Ralph, Burkhardt, Giulia Martina, Cavestro, Halina, Cichoz-Lach, Antoni, Farré, Josef, Frank, Giovanni, Gambaro, Sebastian, Gimpfl, Harald, Grallert, Heidi, Griesmann, Robert, Grützmann, Claus, Hellerbrand, Péter, Hegyi, Marcus, Hollenbach, Sevastitia, Iordache, Grazyna, Jurkowska, Volker, Keim, Falk, Kiefer, Sebastian, Krug, Olfert, Landt, Milena Di, Leo, Markus M, Lerch, Philippe, Lévy, Markus, Löffler, Matthias, Löhr, Maren, Ludwig, Milan, Macek, Nuria, Malats, Ewa, Malecka-Panas, Giovanni, Malerba, Karl, Mann, Julia, Mayerle, Sonja, Mohr, Rene H M, Te Morsche, Marie, Motyka, Sebastian, Mueller, Thomas, Müller, Markus M, Nöthen, Sergio, Pedrazzoli, Stephen P, Pereira, Annette, Peters, Roland, Pfützer, Francisco X, Real, Vinciane, Rebours, Monika, Ridinger, Marcella, Rietschel, Eva, Rösmann, Adrian, Saftoiu, Alexander, Schneider, Hans-Ulrich, Schulz, Nicole, Soranzo, Michael, Soyka, Peter, Simon, James, Skipworth, Felix, Stickel, Konstantin, Strauch, Michael, Stumvoll, Pier Alberto, Testoni, Anke, Tönjes, Lena, Werner, Jens, Werner, Norbert, Wodarz, Martin, Ziegler, Atsushi, Masamune, Joachim, Mössner, Claude, Férec, Patrick, Michl, Joost, P H Drenth, Heiko, Witt, Markus, Scholz, Miklós, Sahin-Tóth

Publikováno v: Gut. 67(10)

Alcohol-related pancreatitis is associated with a disproportionately large number of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility to alcoholic chronic pancreatitis (CP) is poorly characterised. To ident

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bbddcb3d57dd1ab1952e7fbdd1e3e0e3
https://pubmed.ncbi.nlm.nih.gov/28951524