Zobrazeno 1 - 10
of 360
pro vyhledávání: '"Rene Gonzalez"'
Publikováno v:
Cancers, Vol 15, Iss 10, p 2755 (2023)
The aim of this study was to evaluate the effect of linker on tumor targeting and biodistribution of 67Cu-NOTA-PEG2Nle-CycMSHhex {67Cu-1,4,7-triazacyclononane-1,4,7-triyl-triacetic acid-polyethylene glycol-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-CONH2} and 6
Externí odkaz:
https://doaj.org/article/b64105fafa5240ecb961ce9cacf8a397
Autor:
Felicity Newell, James S. Wilmott, Peter A. Johansson, Katia Nones, Venkateswar Addala, Pamela Mukhopadhyay, Natasa Broit, Carol M. Amato, Robert Van Gulick, Stephen H. Kazakoff, Ann-Marie Patch, Lambros T. Koufariotis, Vanessa Lakis, Conrad Leonard, Scott Wood, Oliver Holmes, Qinying Xu, Karl Lewis, Theresa Medina, Rene Gonzalez, Robyn P. M. Saw, Andrew J. Spillane, Jonathan R. Stretch, Robert V. Rawson, Peter M. Ferguson, Tristan J. Dodds, John F. Thompson, Georgina V. Long, Mitchell P. Levesque, William A. Robinson, John V. Pearson, Graham J. Mann, Richard A. Scolyer, Nicola Waddell, Nicholas K. Hayward
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Acral melanoma occurs on the soles of the feet, palms of the hands and in nail beds. Here, the authors reports the genomic landscape of 87 acral melanomas and find that some tumors harbor a UV signature and that the tumors are diverse at the levels o
Externí odkaz:
https://doaj.org/article/953bcceaafac4fed9eb837e6a8612ce4
Autor:
Elizabeth I. Buchbinder, Janice P. Dutcher, Gregory A. Daniels, Brendan D. Curti, Sapna P. Patel, Shernan G. Holtan, Gerald P. Miletello, Mayer N. Fishman, Rene Gonzalez, Joseph I. Clark, John M. Richart, Christopher D. Lao, Scott S. Tykodi, Ann W. Silk, David F. McDermott
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-7 (2019)
Abstract Background Metastatic melanoma (mM) and renal cell carcinoma (mRCC) are often treated with anti-PD-1 based therapy, however not all patients respond and further therapies are needed. High dose interleukin-2 (HD IL-2) can lead to durable resp
Externí odkaz:
https://doaj.org/article/2501d6126ef24a80bcbed81058801563
Autor:
Richard P. Tobin, Kimberly R. Jordan, Puja Kapoor, Eric Spongberg, Dana Davis, Victoria M. Vorwald, Kasey L. Couts, Dexiang Gao, Derek E. Smith, Jessica S. W. Borgers, Steven Robinson, Carol Amato, Rene Gonzalez, Karl D. Lewis, William A. Robinson, Virginia F. Borges, Martin D. McCarter
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
We sought to identify tumor-secreted factors that altered the frequency of MDSCs and correlated with clinical outcomes in advanced melanoma patients. We focused our study on several of the many factors involved in the expansion and mobilization of MD
Externí odkaz:
https://doaj.org/article/4b0e4ee4dcbf421085fa5d2dfc6e2911
Autor:
Germán Iñiguez, Pedro Gallardo, Juan Jose Castro, Rene Gonzalez, Mirna Garcia, Elena Kakarieka, Sebastian San Martin, Maria Cecilia Johnson, Verónica Mericq, Fernando Cassorla
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2019)
Introduction: Fetal growth restriction may be the consequence of maternal, fetal, or placental factors. The insulin-like growth factors (IGFs) are major determinants of fetal growth, and are expressed in the mother, fetus and placenta in most species
Externí odkaz:
https://doaj.org/article/98c55c2489534fbd80149c5ca925576c
Autor:
Carol M. Amato, Jennifer D. Hintzsche, Keith Wells, Allison Applegate, Nicholas T. Gorden, Victoria M. Vorwald, Richard P. Tobin, Kelsey Nassar, Yiqun G. Shellman, Jihye Kim, Theresa M. Medina, Matthew Rioth, Karl D. Lewis, Martin D. McCarter, Rene Gonzalez, Aik-Choon Tan, William A. Robinson
Publikováno v:
Cancers, Vol 12, Iss 7, p 1943 (2020)
Immunotherapy, such as anti-PD1, has improved the survival of patients with metastatic melanoma. However, predicting which patients will respond to immunotherapy remains a significant knowledge gap. In this study we analyzed pre-immunotherapy treated
Externí odkaz:
https://doaj.org/article/a358f84fee4642f2884e9eca4119e5e5
Autor:
Sandra Aung, Sigrun Hallmeyer, David F. McDermott, Joseph I. Clark, Howard L. Kaufman, Gregory A. Daniels, Sapna P. Patel, John M. Kirkwood, Ryan J. Sullivan, Marc S. Ernstoff, Brendan D. Curti, Elizabeth I. Buchbinder, Rene Gonzalez, John M. Richart, Anasuya Gunturi, Jessica Perritt, Janice Dutcher, Girald P. Miletello, Joe Lutzky, Michael A. Morse
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 4, Iss 1 (2016)
Background High dose interleukin-2 (HD IL-2) can induce durable responses in a subset of patients leading to long-term survival. Immune checkpoint blockade (ICB) has demonstrated similarly durable responses in a larger proportion of patients. However
Externí odkaz:
https://doaj.org/article/44e74afcb6e54cb58b9c7f23eb3b71b5
Autor:
Steven N. Reuland, Nathaniel B. Goldstein, Katie A. Partyka, Shilo Smith, Yuchun Luo, Mayumi Fujita, Rene Gonzalez, Karl Lewis, David A. Norris, Yiqun G. Shellman
Publikováno v:
Biology Open, Vol 1, Iss 2, Pp 92-100 (2012)
Summary The BH3 mimetic ABT-737 is a potent inhibitor of the anti-apoptotic proteins Bcl-2, Bcl-XL, and Bcl-w. The Bcl-2 family modulates sensitivity to anticancer drugs in many cancers, including melanomas. In this study, we examined whether ABT-737
Externí odkaz:
https://doaj.org/article/f0a870b611c94139a97fd7b3100725a6
Autor:
Ana Laura Pereira Suarez, Mario Alejandro Lorenzetti, Rene Gonzalez Lucano, Melina Cohen, Hugo Gass, Paula Martinez Vazquez, Pedro Gonzalez, Maria V Preciado, Paola Chabay
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61613 (2013)
BackgroundThe etiology and the molecular mechanisms related to breast carcinogenesis remain poorly understood. Some recent reports have examined the role of Human Papillomavirus (HPV) in this disease. The purpose of this study was to determine the pr
Externí odkaz:
https://doaj.org/article/45029f47f48b4cd38b9d1f7a0cae11ea
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 3 (2011)
Melanoma is a malignancy that is highly curable in the early stages but has devastating consequences in later stages due to lack of response to traditional treatments. Improved understanding of the basic science of tumorigenesis has helped lead to no
Externí odkaz:
https://doaj.org/article/197011abc019495b97e18990a29f6a91