Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Rene Galien"'
Autor:
Xavier Roblin, Adrian Serone, Oh Kyu Yoon, Luting Zhuo, Ethan Grant, Geert R. D'Haens, Rene Galien, Jacky Woo, Jinfeng Liu
Publikováno v:
Inflammatory bowel diseases, 28(8), 1207-1218. John Wiley and Sons Inc.
Background Pro-inflammatory cytokines are dysregulated in Crohn’s disease (CD) and could serve as surrogate markers to improve diagnostic and therapeutic approaches, potentially addressing an unmet need. We profiled circulating biomarkers and whole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9667d994057ee65650c4371d28dc584d
https://pure.amc.nl/en/publications/effects-of-jak1preferential-inhibitor-filgotinib-on-circulating-biomarkers-and-whole-blood-genespathways-of-patients-with-moderately-to-severely-active-crohns-disease(d85f086f-a574-4321-906c-58827389c799).html
https://pure.amc.nl/en/publications/effects-of-jak1preferential-inhibitor-filgotinib-on-circulating-biomarkers-and-whole-blood-genespathways-of-patients-with-moderately-to-severely-active-crohns-disease(d85f086f-a574-4321-906c-58827389c799).html
Autor:
W Li, Peter C. Taylor, J Tarrant, L Goyal, R. E. Hawtin, Wangshu Zhang, Y Pan, Annegret Van der Aa, Rene Galien
Publikováno v:
Rheumatology and Therapy, Vol 7, Iss 1, Pp 173-190 (2020)
Rheumatology and Therapy
Rheumatology and Therapy
Introduction The Janus kinase (JAK) inhibitor therapeutic class has shown significant clinical benefit in the treatment of rheumatoid arthritis (RA). We sought to gain insight into the mode of action and immunological effects of filgotinib, a JAK1 se
Autor:
Jason Goh, Xavier Roblin, Oh Kyu Yoon, Rene Galien, Geert R. D'Haens, Jacky Woo, Ethan Grant, Adrian Serone, James Lui, Luting Zhuo
Publikováno v:
Posters.
Autor:
Oh Kyu Yoon, Adrian Serone, Robert Petryka, Chantal Tasset, Severine Vermeire, Xavier Roblin, Jason Goh, Shiva Zaboli, Xavier Hébuterne, Maria Kłopocka, Jens Brodbeck, Ethan Grant, Rene Galien, Walter Reinisch
Publikováno v:
Posters.
Introduction Filgotinib (FIL) is a JAK1 inhibitor under phase 3 clinical evaluation for treatment of IBD. We conducted a post hoc analysis in patients (pts) with moderately to severely active Crohn’s disease (CD) to assess the effect of FIL on mark
Autor:
Mykola Stanislavchuk, Frédéric Vanhoutte, Minodora Mazur, Rene Galien, L. Meuleners, Oleksandr Voloshyn, Florence Namour, Annegret Van der Aa, Gerben van ’t Klooster
Publikováno v:
Arthritis & Rheumatology (Hoboken, N.j.)
Objective JAK inhibitors have shown efficacy in rheumatoid arthritis (RA). We undertook this study to test our hypothesis that selective inhibition of JAK-1 would combine good efficacy with a better safety profile compared with less selective JAK inh
Autor:
Oh Kyu Yoon, Wendy Jiang, Corrine Jamoul, M. Trivedi, Rene Galien, Jiyun Kim, Neelufar Mozaffarian, Dafna D. Gladman
Publikováno v:
Poster Presentations.
Background PsA is a chronic inflammatory musculoskeletal disease characterized by joint and skin inflammation, enthesitis, dactylitis, and nail lesions. In the recent EQUATOR study, filgotinib (FIL), an oral, selective Janus kinase 1 (JAK1) inhibitor
Autor:
Johan Beetens, Rene Galien, Tim Van Kaem, Gerben van ’t Klooster, Frédéric Vanhoutte, Annegret Van der Aa, Florence Namour
Publikováno v:
British Journal of Clinical Pharmacology
Aims Free fatty acids (FFA) can act as direct signalling molecules through activation of several membrane-bound G-protein coupled receptors. The FFA2 receptor (known as GPR43) is activated by short chain fatty acids (SCFA) such as acetate and has bee
Autor:
Y. Tian, Walter P. Maksymowych, W. Barchuk, Y. Liu, A. Hertz, R. Besuyen, Vladislav A. Malkov, Rene Galien, A. M. Mirza, Oh Kyu Yoon
Publikováno v:
Annals of the Rheumatic Diseases. 79:730.2-731
Background:Ankylosing spondylitis (AS) is a chronic, immune-mediated disease characterized by inflammation of the sacroiliac joints and spine, and a young age of onset of 20–40 years. In the recent TORTUGA study, filgotinib (FIL), an oral, selectiv
Autor:
Shiva Zaboli, Severine Vermeire, Chantal Tasset, Walter Reinisch, Rene Galien, Maria Kłopocka, Xavier Hébuterne, Ethan Grant, Adrian Serone, Oh Kyu Yoon, Robert Petryka, Jens Brodbeck, Xavier Roblin
Publikováno v:
Gastroenterology. 158:S-1200
Autor:
Rene Galien, James Liu, Luting Zhuo, Ethan Grant, Xavier Roblin, Geert R. D'Haens, Adrian Serone, Jacky Woo, Oh Kyu Yoon
Publikováno v:
Gastroenterology. 158:S-1201