Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Rene G. Ott"'
Publikováno v:
Cellular signalling. 68
The target of rapamycin complex 1 (TORC1) protein kinase is activated by nutrients and controls nutrient uptake via the membrane trafficking of various nutrient permeases. However, its molecular mechanisms remain elusive. Cholesterol (ergosterol in y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee13f8c577a9ad168659cf7bc8318423
https://pubmed.ncbi.nlm.nih.gov/31954176
https://pubmed.ncbi.nlm.nih.gov/31954176
Autor:
John R. Mascola, Bimal K. Chakrabarti, John Pietzsch, Richard T. Wyatt, Michel C. Nussenzweig, Jeffrey V. Ravetch, Johannes F. Scheid, Hedda Wardemann, Hugo Mouquet, Bruce D. Walker, David D. Ho, Mark Connors, Yuxing Li, Arlene Hurley, Klara Velinzon, Niklas Feldhahn, Rene G. Ott, Henry Zebroski, Robert M. Anthony, Michael S. Seaman, Adhuna Phogat, Florencia Pereyra
Publikováno v:
Nature. 458:636-640
Serologic memory is an important factor in long-term vaccine efficacy, but there is little understanding of the antibodies produced by memory B cells in individuals infected with important human pathogens such as HIV. To examine the memory antibody r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::522f992188fb5cac8f79d2b1f01c31d3
https://doi.org/10.1038/nature07930
https://doi.org/10.1038/nature07930
Autor:
K. Dane Wittrup, Bruce Tidor, Rene G. Ott, Jeffrey V. Ravetch, Stephen L. Sazinsky, Nathaniel W. Silver
Publikováno v:
Proceedings of the National Academy of Sciences. 105:20167-20172
Immunoglobulin G plays a vital role in adaptive immunity and antibody-based therapy through engagement of its Fc region by the Fc gamma receptors (Fc gammaRs) on immune cells. In addition to specific protein-protein contacts, N-linked glycosylation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe9d6c4b8f81cd98b560893a7faeb66
https://doi.org/10.1073/pnas.0809257105
https://doi.org/10.1073/pnas.0809257105
Autor:
Karoline V. Gleixner, Puchit Samorapoompichit, Christian Sillaber, Eva Jaeger, Hideaki Nakamura, Winfried F. Pickl, Khaled Greish, Gregor Hoermann, Harald Esterbauer, Julia Mayerhofer, Ilse Schwarzinger, Hiroshi Maeda, Karl J. Aichberger, Sophia Derdak, Rene G. Ott, Peter Valent, Veronika Sexl, Matthias Mayerhofer
Publikováno v:
Blood. 111:2200-2210
Resistance toward imatinib and other BCR/ABL tyrosine kinase inhibitors remains an increasing clinical problem in the treatment of advanced stages of chronic myeloid leukemia (CML). We recently have identified the heat shock protein 32 (Hsp32)/heme o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15050cec5d95ba3778b8568f9613bd2e
https://doi.org/10.1182/blood-2006-11-055723
https://doi.org/10.1182/blood-2006-11-055723
Autor:
Wilhelm G. Dirks, Isabella Bambach, Helmut Bergler, Paul Vesely, Rene G. Ott, Philipp B. Staber, Silvia Schauer, Lukas Kenner, Veronika Sexl, Kotaro Funato, Marshall E. Kadin, Naznin Haq, Andelko Hrzenjak, Werner Linkesch, Gerald Hoefler, Claudia Fuchs, David W. Sternberg
Publikováno v:
Blood. 110:3374-3383
Anaplastic large cell lymphomas (ALCLs) are highly proliferating tumors that commonly express the AP-1 transcription factor JunB. ALK fusions occur in approximately 50% of ALCLs, and among these, 80% have the t(2;5) translocation with NPM-ALK express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab31878554e7a07fbd388504a8eaa9f4
https://doi.org/10.1182/blood-2007-02-071258
https://doi.org/10.1182/blood-2007-02-071258
Autor:
Rene G. Ott, Michael Freissmuth, Eva Weisz, Rita Kreibich, Hartmut Beug, Dagmar Stoiber, Boris Kovacic, David E. Levy, Richard Moriggl, Veronika Sexl
Publikováno v:
Cancer Cell. 10(1):77-87
The tumor suppressor STAT1 is considered a key regulator of the surveillance of developing tumors. Here, we describe an unexpected tumor-promoting role for STAT1 in leukemia. STAT1(-/-) mice are partially protected from leukemia development, and STAT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe4d592c3f06d746d6a39e714117bca
Autor:
Karoline Kollmann, Christine Schneckenleithner, Gerwin Heller, Veronika Sexl, Eva Eckelhart, Olivia Simma, Eva Zebedin-Brandl, Andrea Hoelbl, Rene G. Ott, Sabine Zöchbauer-Müller, Ruth Scheicher, Marcos Malumbres, Martin Bilban, Wolfgang Warsch
Publikováno v:
Blood. 117(15)
The transcription factor c-JUN and its upstream kinase JNK1 have been implicated in BCR-ABL–induced leukemogenesis. JNK1 has been shown to regulate BCL2 expression, thereby altering leukemogenesis, but the impact of c-JUN remained unclear. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c762c7c9c5860637a965b8f4f518fb
https://pubmed.ncbi.nlm.nih.gov/21300982
https://pubmed.ncbi.nlm.nih.gov/21300982
Autor:
Herman N. Eisen, Shetha Shukair, Johannes F. Scheid, Arup K. Chakraborty, Michel C. Nussenzweig, Patrick C. Wilson, Thomas J. Hope, Florencia Pereyra, Bruce D. Walker, David D. Ho, Mark Connors, John Pietzsch, Hugo Mouquet, Maxim N. Artyomov, Michael S. Seaman, Jeffrey V. Ravetch, Rene G. Ott, Hedda Wardemann, Michelle Krogsgaard, Markus Josef Zoller
Publikováno v:
Nature. 467(7315)
During immune responses, antibodies are selected for their ability to bind to foreign antigens with high affinity, in part by their ability to undergo homotypic bivalent binding. However, this type of binding is not always possible. For example, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::337e22a2c84acee119786a8268cd4b47
https://pubmed.ncbi.nlm.nih.gov/20882002
https://pubmed.ncbi.nlm.nih.gov/20882002
Autor:
Eva-Maria Zebedin, Gerwin Heller, S Zöchbauer, Erwin F. Wagner, Olivia Simma, Michael Freissmuth, Rene G. Ott, Marina Schorpp-Kistner, Eva Weisz, Veronika Sexl, Karoline Kollmann
Publikováno v:
Oncogene. 26(33)
Loss of JunB has been observed in human leukemia and lymphoma, but it remains unknown, whether this loss is relevant to disease progression. Here, we investigated the consequences of JunB deficiency using Abelson-induced B-lymphoid leukemia as a mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e08c6f1c2f640c6e4c71b7f5766e3479
https://pubmed.ncbi.nlm.nih.gov/17297445
https://pubmed.ncbi.nlm.nih.gov/17297445
Autor:
Helmut Bergler, Rene G. Ott, Karin Athenstaedt, Erich Leitner, Claudia Hrastnik, Günther Daum
Publikováno v:
TU Graz
Lanosterol C-14 demethylase Erg11p of the yeast Saccharomyces cerevisiae catalyzes the enzymatic step following formation of lanosterol by the lanosterol synthase Erg7p in lipid particles (LP). Localization experiments employing microscopic inspectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03ebf45f76ca2dcd194d9603d5e57a3b
https://pubmed.ncbi.nlm.nih.gov/15951236
https://pubmed.ncbi.nlm.nih.gov/15951236