Zobrazeno 1 - 10 of 47 pro vyhledávání: '"Rene Figueredo"'
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Akademický článek
IDO Downregulation Induces Sensitivity to Pemetrexed, Gemcitabine, FK866, and Methoxyamine in Human Cancer Cells.
Autor: Saman Maleki Vareki, Di Chen, Christine Di Cresce, Peter J Ferguson, Rene Figueredo, Macarena Pampillo, Mateusz Rytelewski, Mark Vincent, Weiping Min, Xiufen Zheng, James Koropatnick
Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0143435 (2015)
Indoleamine 2,3-dioxygenase-1 (IDO) is an immune regulatory enzyme expressed by most human tumors. IDO levels in tumor cells correlate with increased metastasis and poor patient outcome and IDO is linked to tumor cell resistance to immunotherapy, rad
Externí odkaz: https://doaj.org/article/e30136094b0f4f87a8c34385fcaf3fbd
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3
Akademický článek
Inhibition of BRCA2 and Thymidylate Synthase Creates Multidrug Sensitive Tumor Cells via the Induction of Combined 'Complementary Lethality'
Autor: Mateusz Rytelewski, Peter J Ferguson, Saman Maleki Vareki, Rene Figueredo, Mark Vincent, James Koropatnick
Publikováno v: Molecular Therapy: Nucleic Acids, Vol 2, Iss C (2013)
A high mutation rate leading to tumor cell heterogeneity is a driver of malignancy in human cancers. Paradoxically, however, genomic instability can also render tumors vulnerable to therapeutic attack. Thus, targeting DNA repair may induce an intoler
Externí odkaz: https://doaj.org/article/e84208e9380445daa66005f7cd1fbf3b
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4
Akademický článek
Magnetic Resonance Imaging of Cells Overexpressing MagA, an Endogenous Contrast Agent for Live Cell Imaging
Autor: Donna E. Goldhawk, Claude Lemaire, Cheryl R. McCreary, Rebecca McGirr, Savita Dhanvantari, R. Terry Thompson, Rene Figueredo, Jim Koropatnick, Paula Foster, Frank S. Prato
Publikováno v: Molecular Imaging, Vol 8 (2009)
Molecular imaging with magnetic resonance imaging (MRI) may benefit from the ferrimagnetic properties of magnetosomes, membrane-enclosed iron biominerals whose formation in magnetotactic bacteria is encoded by multiple genes. One such gene is MagA ,
Externí odkaz: https://doaj.org/article/6778a2380fe44b9f826c9355f0287f1f
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5
Inducing mismatch repair deficiency sensitizes immune-cold neuroblastoma to anti-CTLA4 and generates broad anti-tumor immune memory
Autor: Mikal El-Hajjar, Lara Gerhardt, Megan M Y Hong, Mithunah Krishnamoorthy, Rene Figueredo, Xiufen Zheng, James Koropatnick, Saman Maleki Vareki
Publikováno v: Molecular Therapy. 31:535-551
Immune checkpoint blockade can induce potent and durable responses in patients with highly immunogenic mismatch repair-deficient tumors; however, these drugs are ineffective against immune-cold neuroblastoma tumors. To establish a role for a T cell-b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6be47af0ce3e39a6867edc567c153a
https://doi.org/10.1016/j.ymthe.2022.08.025
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8
IL-12 and IL-27 Promote CD39 Expression on CD8(+) T Cells and Differentially Regulate the CD39(+)CD8(+) T Cell Phenotype
Autor: Lara Gerhardt, Megan M. Y. Hong, Yeganeh Yousefi, Rene Figueredo, Saman Maleki Vareki
Publikováno v: J Immunol
Tumor-specific CD8+ T cells are critical components of antitumor immunity; however, factors that modulate their phenotype and function have not been completely elucidated. Cytokines IL-12 and IL-27 have recognized roles in promoting CD8+ T cells’ e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0b318f116ee3adde3077bc08370f6f
https://europepmc.org/articles/PMC10152038/
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