Interaction analysis between HLA-DRB1 shared epitope alleles and MHC class II transactivator CIITA gene with regard to risk of rheumatoid arthritis.

Autor: Marcus Ronninger, Maria Seddighzadeh, Morten Christoph Eike, Darren Plant, Nina A Daha, Beate Skinningsrud, Jane Worthington, Tore K Kvien, Rene E M Toes, Benedicte A Lie, Lars Alfredsson, Leonid Padyukov

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e32861 (2012)

HLA-DRB1 shared epitope (SE) alleles are the strongest genetic determinants for autoantibody positive rheumatoid arthritis (RA). One of the key regulators in expression of HLA class II receptors is MHC class II transactivator (CIITA). A variant of th

Externí odkaz: https://doaj.org/article/8a36cd766198420392d7d345949bfe68

A large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q33.2.

Autor: Monica Chang, Charles M Rowland, Veronica E Garcia, Steven J Schrodi, Joseph J Catanese, Annette H M van der Helm-van Mil, Kristin G Ardlie, Christopher I Amos, Lindsey A Criswell, Daniel L Kastner, Peter K Gregersen, Fina A S Kurreeman, Rene E M Toes, Tom W J Huizinga, Michael F Seldin, Ann B Begovich

Publikováno v: PLoS Genetics, Vol 4, Iss 6, p e1000107 (2008)

Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease affecting both joints and extra-articular tissues. Although some genetic risk factors for RA are well-established, most notably HLA-DRB1 and PTPN22, these markers do not fully accoun

Externí odkaz: https://doaj.org/article/06b63f94b8694508a11164750601eaa3

Altered composition and phenotype of mucosal-associated invariant T cells in early untreated rheumatoid arthritis

Autor: Hester Koppejan, Diahann T. S. L. Jansen, Marjolijn Hameetman, Ranjeny Thomas, Rene E. M. Toes, Floris A. van Gaalen

Publikováno v: Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-7 (2019)

Abstract Background Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognise bacterial metabolites presented by MHC class I-related protein 1 (MR1). Bacterial dysbiosis has been implicated in auto-inflammatory disease develo

Externí odkaz: https://doaj.org/article/1ca0d237c8f44524813859166c7572b3

IgG Anti-Citrullinated Protein Antibody Variable Domain Glycosylation Increases Before the Onset of Rheumatoid Arthritis and Stabilizes Thereafter: A Cross-Sectional Study Encompassing ~1,500 Samples

Autor: Theresa Kissel, Lise Hafkenscheid, Tineke J. Wesemael, Mami Tamai, Shin‐ya Kawashiri, Atsushi Kawakami, Hani S. El‐Gabalawy, Dirkjan van Schaardenburg, Solbritt Rantapää‐Dahlqvist, Manfred Wuhrer, Annette H. M. van der Helm‐van Mil, Cornelia F. Allaart, Diane van der Woude, Hans U. Scherer, Rene E. M. Toes, Tom W. J. Huizinga

Publikováno v: Kissel, T, Hafkenscheid, L, Wesemael, T J, Tamai, M, Kawashiri, S, Kawakami, A, el-Gabalawy, H S, van Schaardenburg, D, Rantapää-Dahlqvist, S, Wuhrer, M, van der Helm-van Mil, A H M, Allaart, C F, van der Woude, D, Scherer, H U, Toes, R E M & Huizinga, T W J 2022, ' IgG Anti–Citrullinated Protein Antibody Variable Domain Glycosylation Increases Before the Onset of Rheumatoid Arthritis and Stabilizes Thereafter : A Cross-Sectional Study Encompassing ~1,500 Samples ', Arthritis and Rheumatology, vol. 74, no. 7, pp. 1147-1158 . https://doi.org/10.1002/art.42098
Arthritis & Rheumatolgy
Arthritis and Rheumatology, 74(7), 1147-1158. John Wiley and Sons Ltd
Kissel, T, Hafkenscheid, L, Wesemael, T J, Tamai, M, Kawashiri, S-Y, Kawakami, A, El-Gabalawy, H S, van Schaardenburg, D, Rantapää-Dahlqvist, S, Wuhrer, M, van der Helm-van Mil, A H M, Allaart, C F, van der Woude, D, Scherer, H U, Toes, R E M & Huizinga, T W J 2022, ' IgG Anti–Citrullinated Protein Antibody Variable Domain Glycosylation Increases Before the Onset of Rheumatoid Arthritis and Stabilizes Thereafter: A Cross Sectional Study Encompassing ~1,500 Samples ', Arthritis and Rheumatology, vol. 74, no. 7, pp. 1147-1158 . https://doi.org/10.1002/art.42098
Arthritis & Rheumatology, 74(7), 1147-1158. WILEY

Objective: The autoimmune response in rheumatoid arthritis (RA) is marked by the presence of anti–citrullinated protein antibodies (ACPAs). A notable feature of IgG ACPA is the abundant expression of N-linked glycans in the variable domain. However

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15f367b13ff447990929d8690202733d
https://pubmed.ncbi.nlm.nih.gov/35188715

A Comparison of Immunoglobulin Variable Region N-Linked Glycosylation in Healthy Donors, Autoimmune Disease and Lymphoma

Autor: Esther M. Vletter, Marvyn T. Koning, Hans Ulrich Scherer, Hendrik Veelken, Rene E. M. Toes

Publikováno v: Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology, 11. FRONTIERS MEDIA SA
Frontiers in Immunology

N-linked glycans play an important role in immunity. Although the role of N-linked glycans in the Fragment crystallizable (Fc) region of immunoglobulins has been thoroughly described, the function of N-linked glycans present in Ig-variable domains is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fccd31a389a1adb6d561c41a07bd006
https://www.frontiersin.org/article/10.3389/fimmu.2020.00241/full