Ligand-independent Dimerization of the Extracellular Domain of the Leptin Receptor and Determination of the Stoichiometry of Leptin Binding

Autor: Geert Plaetinck, Rene Devos, Michael Kalai, Michael Fountoulakis, David White, José Van der Heyden, Yves Guisez

Publikováno v: Journal of Biological Chemistry. 272:18304-18310

The leptin receptor is a class I transmembrane protein with either a short or a long cytoplasmic domain. Using chemical cross-linking we have analyzed the binding of leptin to its receptor. Cross-linking of radiolabeled leptin to different isoforms o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3ff87ec7d2eca4a440321e297ac6735
https://doi.org/10.1074/jbc.272.29.18304

Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator

Autor: Hazel Hunt, Pu Hu, Ioannis Zalachoras, A. M. I. Tijssen, Joseph K. Belanoff, Rene Devos, Peter Lockey, Erika Atucha, Marian Joëls, Nicole A. Datson, René Houtman, Benno Roozendaal, Onno C. Meijer, Paul J. Lucassen, E. Ronald de Kloet

Publikováno v: Proceedings of the National Academy of Sciences USA, 110, 19, pp. 7910-5
Proceedings of the National Academy of Sciences USA, 110, 7910-5
Proceedings of the National Academy of Sciences of the United States of America, 110(19), 7910-7915. National Academy of Sciences
Proceedings of the National Academy of Sciences, 110(19), 7910-7915

Item does not contain fulltext Glucocorticoid receptor (GR) antagonism may be of considerable therapeutic value in stress-related psychopathology such as depression. However, blockade of all GR-dependent processes in the brain will lead to unnecessar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a0ae708b8cb53d942d2b4d1d82f644
https://hdl.handle.net/1887/100618

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

Autor: Rene Devos, Françoise J. Smith, L A Campfield, Yves Guisez, Paul Burn

Publikováno v: Science. 269:546-549

The recent positional cloning of the mouse ob gene and its human homology has provided the basis to investigate the potential role of the ob gene product in body weight regulation. A biologically active form of recombinant mouse OB protein was overex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92edef2a956c3fdb87b14eb0bd8c0219
https://doi.org/10.1126/science.7624778

Interleukin-5 and its receptor: a drug target for eosinophilia associated with chronic allergic disease

Autor: S Cornelis, J Van der Heyden, Yves Guisez, Rene Devos, Jan Tavernier, Geert Plaetinck

Publikováno v: Journal of Leukocyte Biology. 57:813-819

A characteristic feature of chronic allergic diseases such as asthma is the increase in eosinophil numbers in the inflamed tissue. In light of its specificity for the development of eosinophils, interleukin-5 (IL-5) is considered the most important c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe82155dbe2ac88730dc0d18ed4807f
https://doi.org/10.1002/jlb.57.6.813

Precursor frequency analysis of human cytolytic T lymphocytes directed against autologous melanoma cells

Autor: Michel Somville, Thierry Boon, Frederic Lehmann, Pierre Coulie, Francis Brasseur, Philippe Hainaut, Rene Devos

Publikováno v: International Journal of Cancer. 50:289-297

Limiting numbers of peripheral-blood mononuclear cells (PBMC) from melanoma patients were stimulated with irradiated autologous tumor cells in the presence of interleukins-2 and -4 and in the absence of feeder cells. The responder cells were restimul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59e5f25c42878079b1be90e2d577b549
https://doi.org/10.1002/ijc.2910500220