Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Rene Bernards"'
Autor:
Lizelle Correia, Ramiro Magno, Joana M. Xavier, Bernardo P. de Almeida, Isabel Duarte, Filipa Esteves, Marinella Ghezzo, Matthew Eldridge, Chong Sun, Astrid Bosma, Lorenza Mittempergher, Ana Marreiros, Rene Bernards, Carlos Caldas, Suet-Feung Chin, Ana-Teresa Maia
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-9 (2022)
Abstract PIK3CA mutations are the most common in breast cancer, particularly in the estrogen receptor-positive cohort, but the benefit of PI3K inhibitors has had limited success compared with approaches targeting other less common mutations. We found
Externí odkaz:
https://doaj.org/article/1f310d117fd4459e812b3168e8a100cc
Autor:
Sara Mainardi, Rene Bernards
Publikováno v:
Cell Genomics, Vol 2, Iss 2, Pp 100100- (2022)
Hirt et al.1 report an automated, high-throughput drug screening platform for organoid cultures to enable repurposing of previously approved drugs for pancreatic cancers harboring specific genetic alterations. The pancreatic cancer organoid biobank a
Externí odkaz:
https://doaj.org/article/68bc641f478c448390a2732c86b50a0a
Autor:
Ziva Pogacar, Jackie L Johnson, Lenno Krenning, Giulia De Conti, Fleur Jochems, Cor Lieftink, Arno Velds, Leyma Wardak, Kelvin Groot, Arnout Schepers, Liqin Wang, Ji-Ying Song, Marieke van de Ven, Olaf van Tellingen, Rene H Medema, Roderick L Beijersbergen, Rene Bernards, Rodrigo Leite de Oliveira
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0273182 (2022)
Inducing senescence in cancer cells is emerging as a new therapeutic strategy. In order to find ways to enhance senescence induction by palbociclib, a CDK4/6 inhibitor approved for treatment of metastatic breast cancer, we performed functional geneti
Externí odkaz:
https://doaj.org/article/6f29ef7b9b734b128186d1949fb65c09
Autor:
Haojie Jin, Siying Wang, Esther A Zaal, Cun Wang, Haiqiu Wu, Astrid Bosma, Fleur Jochems, Nikita Isima, Guangzhi Jin, Cor Lieftink, Roderick Beijersbergen, Celia R Berkers, Wenxin Qin, Rene Bernards
Publikováno v:
eLife, Vol 9 (2020)
The dependency of cancer cells on glutamine may be exploited therapeutically as a new strategy for treating cancers that lack druggable driver genes. Here we found that human liver cancer was dependent on extracellular glutamine. However, targeting g
Externí odkaz:
https://doaj.org/article/67844f9e629f4631a5c877af93e2e1e6
Autor:
Subarna Sinha, Daniel Thomas, Steven Chan, Yang Gao, Diede Brunen, Damoun Torabi, Andreas Reinisch, David Hernandez, Andy Chan, Erinn B. Rankin, Rene Bernards, Ravindra Majeti, David L. Dill
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
There are no robust methods for systematically identifying mutation-specific synthetic lethal (SL) partners in cancer. Here, the authors develop a computational algorithm that uses pan-cancer data to detect mutation-andcancer-specific SL partners and
Externí odkaz:
https://doaj.org/article/e49e620b8adf451f9e5a7aa02173d0b8
Autor:
Inès J. Beumer, Marion Persoon, Anke Witteveen, Christa Dreezen, Suet-Feung Chin, Stephen-John Sammut, Mireille Snel, Carlos Caldas, Sabine Linn, Laura J. van 't Veer, Rene Bernards, Annuska M. Glas
Publikováno v:
Biomarker Insights, Vol 2016, Iss 11, Pp 139-146 (2016)
Externí odkaz:
https://doaj.org/article/2e3de5bac305406db4c3434460a6f8e8
Autor:
Marcelo Sobral-Leite, Koen Van de Vijver, Magali Michaut, Rianne van der Linden, Gerrit K.J. Hooijer, Hugo M. Horlings, Tesa M. Severson, Anna Marie Mulligan, Nayana Weerasooriya, Joyce Sanders, Annuska M Glas, Diederik Wehkamp, Lorenza Mittempergher, Kelly Kersten, Ashley Cimino-Mathews, Dennis Peters, Erik Hooijberg, Annegien Broeks, Marc J. van de Vijver, Rene Bernards, Irene L. Andrulis, Marleen Kok, Karin E. de Visser, Marjanka K. Schmidt
Publikováno v:
OncoImmunology, Vol 7, Iss 12 (2018)
To better understand the expression pattern of programmed death-ligand 1 (PD-L1) expression in different breast cancer types, we characterized PD-L1 expression in tumor and tumor-infiltrating immune cells, in relation to mutation rate, BRCA1-like sta
Externí odkaz:
https://doaj.org/article/f0b6f6923ae04f0aaadc16be5fe9261c
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 6 (2018)
The clinical responses to targeted drugs are often transient and do not always translate into meaningful overall survival due to the development of resistance. We discuss here that the greater power of drug resistant cells can be associated with sign
Externí odkaz:
https://doaj.org/article/3fce142c14a5481abaf57a5bb6a5b4c2
Autor:
Anirudh Prahallad, Guus J.J.E. Heynen, Giovanni Germano, Stefan M. Willems, Bastiaan Evers, Loredana Vecchione, Valentina Gambino, Cor Lieftink, Roderick L. Beijersbergen, Federica Di Nicolantonio, Alberto Bardelli, Rene Bernards
Publikováno v:
Cell Reports, Vol 12, Iss 12, Pp 1978-1985 (2015)
Most BRAF (V600E) mutant melanomas are sensitive to selective BRAF inhibitors, but BRAF mutant colon cancers are intrinsically resistant to these drugs because of feedback activation of EGFR. We performed an RNA-interference-based genetic screen in B
Externí odkaz:
https://doaj.org/article/ecb00508ecca451a9aef4546ea85d00b
Autor:
Simona Lamba, Mariangela Russo, Chong Sun, Luca Lazzari, Carlotta Cancelliere, Wipawadee Grernrum, Cor Lieftink, Rene Bernards, Federica Di Nicolantonio, Alberto Bardelli
Publikováno v:
Cell Reports, Vol 8, Iss 5, Pp 1475-1483 (2014)
KRAS is the most frequently mutated oncogene in human cancer, yet no therapies are available to treat KRAS mutant cancers. We used two independent reverse genetic approaches to identify components of the RAS-signaling pathways required for growth of
Externí odkaz:
https://doaj.org/article/0548cbb6ffd9481ba6a3ccf3fa4e846b