Zobrazeno 1 - 10
of 498
pro vyhledávání: '"René Csuk"'
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 12, Iss , Pp 100200- (2024)
The scientific community has long been interested in capsaicin, and the extensive hunt for AChE and BChE enzyme inhibitors is still ongoing. In this investigation analogs of capsaicin, such as the pharmaceutical nonivamide, which is preferred in clin
Externí odkaz:
https://doaj.org/article/4bf4932214da4f569189226fe2ecbab2
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 12, Iss , Pp 100198- (2024)
Previous research on acetylated pentacyclic triterpenes had demonstrated the excellent cytotoxic action and, in certain situations, very surprising selectivity of (iso)-quinolinyl amides, in particular. Specifically, compounds derived from asiatic ac
Externí odkaz:
https://doaj.org/article/dad32df60cb4453abe43a590319b9d58
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 12, Iss , Pp 100177- (2024)
A small library of arylsulfonamido-alkyl sulfamates was prepared by a two-step synthesis from readily available starting materials. The compounds were tested for their ability to inhibit bovine carbonic anhydrase II. Several of them were found as goo
Externí odkaz:
https://doaj.org/article/afb6e6bcd7b241d89be30adab3d497ad
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 11, Iss , Pp 100162- (2024)
Aminoalcohols were converted into the corresponding enantiomeric phenylsulfonamide sulfamates. These compounds proved to be inhibitors of carbonic anhydrase II. Interestingly, a sulfamate derived from (S)-tryptophan was no inhibitor at all while its
Externí odkaz:
https://doaj.org/article/41a3ec541db94dcf9c363af72467fb55
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 10, Iss , Pp 100139- (2024)
Earlier studies had shown the potential of modified pentacyclic triterpenes as possible inhibitors of carbonic anhydrase II (CA II). In an extension of our earlier studies, betulin, betulinic acid and, for comparison purposes, glycyrrhetinic acid, ur
Externí odkaz:
https://doaj.org/article/fcdf8bcfbda74d20870e5f7bba024e72
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 10, Iss , Pp 100124- (2024)
The reaction of dehydroabiethylamine (DHA) with isocyanides and formaldehyde produces varying products depending on the conditions employed. In a 4-component Ugi reaction using benzyl isocyanide, paraformaldehyde, and TMS-azide, the anticipated tetra
Externí odkaz:
https://doaj.org/article/3c2fc29be0a44034be1624f3b53f53aa
Publikováno v:
Molecules, Vol 29, Iss 13, p 3015 (2024)
A small library of 79 substituted phenylsulfonamidoalkyl sulfamates, 1b–79b, was synthesized starting from arylsulfonyl chlorides and amino alcohols with different numbers of methylene groups between the hydroxyl and amino moieties yielding interme
Externí odkaz:
https://doaj.org/article/f578283438274f8a9791fd286f346b23
Publikováno v:
Results in Chemistry, Vol 7, Iss , Pp 101426- (2024)
The diterpene isosteviol can easily be synthesized via hydrolysis from stevioside, a renewable resource adding particular utility to its potential for drug synthesis. Of late, there has been an increase in scientific studies focusing on inhibitors of
Externí odkaz:
https://doaj.org/article/9f901af72bb44e10b7fc1136573aa69f
Publikováno v:
Molecules, Vol 29, Iss 10, p 2346 (2024)
Various conjugates with rhodamines were prepared by starting with betulinic acid (BA) and platanic acid (PA). The molecules homopiperazine and piperazine, which were identified in earlier research, served as linkers between the rhodamine and the trit
Externí odkaz:
https://doaj.org/article/decc1abf7fba45c386e305971d1771a9
Autor:
Matthias Bache, Niels V. Heise, Andreas Thiel, Anne Funtan, Franziska Seifert, Marina Petrenko, Antje Güttler, Sarah Brandt, Thomas Mueller, Dirk Vordermark, Iris Thondorf, René Csuk, Reinhard Paschke
Publikováno v:
Pharmaceutics, Vol 16, Iss 3, p 401 (2024)
Human carbonic anhydrase IX (hCA IX) is a zinc(II)-dependent metalloenzyme that plays a critical role in the conversion of carbon dioxide and water to protons and bicarbonate. It is a membrane-bound protein with an extracellular catalytic center that
Externí odkaz:
https://doaj.org/article/92c63e48a550496a81b8ddcea36021ad