Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Rene, Bernards"'
Autor:
Yaoping Shi, Dan Cui, Lei Xia, Donghua Shi, Guangxin Jin, Siying Wang, Yan Lin, Xiaoyin Tang, Jiachang Chi, Tao Wang, Meng Li, Zicheng Lv, Jiaojiao Zheng, Qi Jia, Wu Yang, Zhen Sun, Fan Yang, Hao Feng, Shengxian Yuan, Weiping Zhou, Wenxin Qin, Rene Bernards, Haojie Jin, Bo Zhai
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-7 (2024)
Abstract Lenvatinib, a multi-kinase inhibitor, has been approved as first-line treatment for advanced hepatocellular carcinoma (HCC), but its efficacy is limited. We have shown previously that lenvatinib and epidermal growth factor receptor tyrosine
Externí odkaz:
https://doaj.org/article/65cda05981b24e0da20a9b8d531ce2ef
Autor:
Lizelle Correia, Ramiro Magno, Joana M. Xavier, Bernardo P. de Almeida, Isabel Duarte, Filipa Esteves, Marinella Ghezzo, Matthew Eldridge, Chong Sun, Astrid Bosma, Lorenza Mittempergher, Ana Marreiros, Rene Bernards, Carlos Caldas, Suet-Feung Chin, Ana-Teresa Maia
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-9 (2022)
Abstract PIK3CA mutations are the most common in breast cancer, particularly in the estrogen receptor-positive cohort, but the benefit of PI3K inhibitors has had limited success compared with approaches targeting other less common mutations. We found
Externí odkaz:
https://doaj.org/article/1f310d117fd4459e812b3168e8a100cc
Autor:
Sara Mainardi, Rene Bernards
Publikováno v:
Cell Genomics, Vol 2, Iss 2, Pp 100100- (2022)
Hirt et al.1 report an automated, high-throughput drug screening platform for organoid cultures to enable repurposing of previously approved drugs for pancreatic cancers harboring specific genetic alterations. The pancreatic cancer organoid biobank a
Externí odkaz:
https://doaj.org/article/68bc641f478c448390a2732c86b50a0a
Autor:
Ziva Pogacar, Jackie L Johnson, Lenno Krenning, Giulia De Conti, Fleur Jochems, Cor Lieftink, Arno Velds, Leyma Wardak, Kelvin Groot, Arnout Schepers, Liqin Wang, Ji-Ying Song, Marieke van de Ven, Olaf van Tellingen, Rene H Medema, Roderick L Beijersbergen, Rene Bernards, Rodrigo Leite de Oliveira
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0273182 (2022)
Inducing senescence in cancer cells is emerging as a new therapeutic strategy. In order to find ways to enhance senescence induction by palbociclib, a CDK4/6 inhibitor approved for treatment of metastatic breast cancer, we performed functional geneti
Externí odkaz:
https://doaj.org/article/6f29ef7b9b734b128186d1949fb65c09
Autor:
Sherene Loi, Jeffrey Settleman, Johanna A. Joyce, C.S. Pramesh, Rene Bernards, Jia Fan, Juanita L. Merchant, Javid Moslehi, William R. Sellers
Publikováno v:
Cell. 186:1523-1527
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41c7ffdd9acbffc8da41b1c47e8814ac
https://doi.org/10.1016/j.cell.2023.01.037
https://doi.org/10.1016/j.cell.2023.01.037
Autor:
Haojie Jin, Siying Wang, Esther A Zaal, Cun Wang, Haiqiu Wu, Astrid Bosma, Fleur Jochems, Nikita Isima, Guangzhi Jin, Cor Lieftink, Roderick Beijersbergen, Celia R Berkers, Wenxin Qin, Rene Bernards
Publikováno v:
eLife, Vol 9 (2020)
The dependency of cancer cells on glutamine may be exploited therapeutically as a new strategy for treating cancers that lack druggable driver genes. Here we found that human liver cancer was dependent on extracellular glutamine. However, targeting g
Externí odkaz:
https://doaj.org/article/67844f9e629f4631a5c877af93e2e1e6
Autor:
Subarna Sinha, Daniel Thomas, Steven Chan, Yang Gao, Diede Brunen, Damoun Torabi, Andreas Reinisch, David Hernandez, Andy Chan, Erinn B. Rankin, Rene Bernards, Ravindra Majeti, David L. Dill
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
There are no robust methods for systematically identifying mutation-specific synthetic lethal (SL) partners in cancer. Here, the authors develop a computational algorithm that uses pan-cancer data to detect mutation-andcancer-specific SL partners and
Externí odkaz:
https://doaj.org/article/e49e620b8adf451f9e5a7aa02173d0b8
Autor:
Prashanth Kumar Bajpe, Rene Bernards, Wilbert Zwart, Andreas Schlicker, Cor Lieftink, Noorjahan Jagalur Basheer, Sander Palit, Ekaterina Nevedomskaya, Guus J.J.E. Heynen
Supplementary Table 5: Sources of publicly available ChIP-seq data for p300 and H3K27me1 in SK-N-SH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ea7995174744416df77680f2cd7729
https://doi.org/10.1158/1541-7786.22510723
https://doi.org/10.1158/1541-7786.22510723
Autor:
Prashanth Kumar Bajpe, Rene Bernards, Wilbert Zwart, Andreas Schlicker, Cor Lieftink, Noorjahan Jagalur Basheer, Sander Palit, Ekaterina Nevedomskaya, Guus J.J.E. Heynen
Neuroblastoma cell lines can differentiate upon treatment with retinoic acid (RA), a finding that provided the basis for the clinical use of RA to treat neuroblastoma. However, resistance to RA is often observed, which limits its clinical utility. Us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54acb9b7a465ea7798f295b279887b7f
https://doi.org/10.1158/1541-7786.c.6539704
https://doi.org/10.1158/1541-7786.c.6539704
Autor:
Prashanth Kumar Bajpe, Rene Bernards, Wilbert Zwart, Andreas Schlicker, Cor Lieftink, Noorjahan Jagalur Basheer, Sander Palit, Ekaterina Nevedomskaya, Guus J.J.E. Heynen
Supplementary method, Supplementary figures and supplementary figure legends: Supplementary Figure 1. Viral VBIM integration site in MAML3 gene and equal sensitivity to cisplatin of parental and SD3.23 cells. Supplementary Figure 2. Overexpression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ef1a1e8aceeb92e0a88e1b2a6fdccf
https://doi.org/10.1158/1541-7786.22510741.v1
https://doi.org/10.1158/1541-7786.22510741.v1