The MacBlue binary transgene (csf1r-gal4VP16/UAS-ECFP) provides a novel marker for visualisation of subsets of monocytes, macrophages and dendritic cells and responsiveness to CSF1 administration

Autor: Sauter, Kristin A, Pridans, Clare, Sehgal, Anuj, Bain, Calum, Scott, Charlotte, Moffat, Lindsey, Rojo, Rocío, Stutchfield, Ben M, Davies, Claire, Donaldson, David S, Renault, Kathleen, McColl, Barry W, Mowat, Alan M, Serrels, Alan, Frame, Margaret C, Mabbott, Neil A, Hume, David A

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e105429 (2014)
PLOS ONE
Sauter, K A, Pridans, C, Sehgal, A, Bain, C, Scott, C, Moffat, L, Rojo, R, Stutchfield, B M, Davies, C, Donaldson, D S, Renault, K, McColl, B W, Mowat, A M, Serrels, A, Frame, M C, Mabbott, N A & Hume, D A 2014, ' The MacBlue Binary Transgene (csf1r-gal4VP16/UAS-ECFP) Provides a Novel Marker for Visualisation of Subsets of Monocytes, Macrophages and Dendritic Cells and Responsiveness to CSF1 Administration ', PLoS ONE, vol. 9, no. 8, pp. e105429 . https://doi.org/10.1371/journal.pone.0105429

The MacBlue transgenic mouse uses the Csf1r promoter and first intron to drive expression of gal4-VP16, which in turn drives a cointegrated gal4-responsive UAS-ECFP cassette. The Csf1r promoter region used contains a deletion of a 150 bp conserved re

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http://europepmc.org/articles/PMC4138162?pdf=render