Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Renaud Maroy"'
Autor:
Hervé Boutin, Christian Prenant, Renaud Maroy, James Galea, Andrew D Greenhalgh, Alison Smigova, Christopher Cawthorne, Peter Julyan, Shane M Wilkinson, Samuel D Banister, Gavin Brown, Karl Herholz, Michael Kassiou, Nancy J Rothwell
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56441 (2013)
PurposeNeuroinflammation is involved in several brain disorders and can be monitored through expression of the translocator protein 18 kDa (TSPO) on activated microglia. In recent years, several new PET radioligands for TSPO have been evaluated in di
Externí odkaz:
https://doaj.org/article/aa87008173174959b566bbd213706a64
Autor:
Claire Leroy, Renaud Maroy, Fabienne Picard, Sepideh Sadaghiani, Delphine S. Courvoisier, Michel Bottlaender
Publikováno v:
NeuroImage, Vol. 79 (2013) pp. 42-51
The nicotinic system plays an important role in ordinary cognition, particularly in attention. The main nicotinic receptor in the human brain is the heteromeric α4β2 neuronal nicotinic acetylcholine receptor (nAChR), which is distributed throughout
Autor:
Philippe Damier, Véronique Gaura, Anne-Catherine Bachoud-Lévi, M. J. Ribeiro, P. Hantraye, Gwenaëlle Douaud, Pierre Krystkowiak, Philippe Remy, F. Lethimonnier, Renaud Maroy, Christophe Verny
The striatum, a subcortical structure, is the principal target of the neurodegenerative process in Huntington’s disease (HD). The measurement of striatal atrophy using the bicaudate ratio on CT scanner images has therefore been used for years to as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::910b19ef3d0a4af763f3f9f4ec0d0c56
https://doi.org/10.1016/j.neuroimage.2006.05.057
https://doi.org/10.1016/j.neuroimage.2006.05.057
Autor:
Christopher Cawthorne, Renaud Maroy, Hervé Boutin, Alison Smigova, Christian Prenant, Nancy J. Rothwell, Peter J Julyan, Karl Herholz
Publikováno v:
British Journal of Pharmacology. 162:659-672
BACKGROUND AND PURPOSE: Positron emission tomography (PET) has the potential to improve our understanding of the preclinical pharmacokinetics and metabolism of therapeutic agents, and is easily translated to clinical studies in humans. However, studi
Autor:
Adam Denes, Renaud Maroy, Christian Prenant, James C. Russell, Johann R. Selvarajah, Sharon Hulme, Pippa J. Tyrrell, Alexander Gerhard, Stuart M. Allan, Stephen J. Hopkins, Matthew Jones, Peter J Julyan, Karl Herholz, Rainer Hinz, Nancy J. Rothwell, Rachel Georgiou, David C. Crossman, Alison Smigova, Caroline Drake, Hervé Boutin, Gavin Brown, Barry W. McColl, Andy Vail, Michael Kassiou, Sheila E. Francis, Spencer D. Proctor
Publikováno v:
Brain, Behavior, and Immunity
Brain, Behavior, and Immunity; Vol 25
Drake, C, Boutin, H, Jones, M S, Denes, A, McColl, B W, Selvarajah, J R, Hulme, S, Georgiou, R F, Hinz, R, Gerhard, A, Vail, A, Prenant, C, Julyan, P, Maroy, R, Brown, G, Smigova, A, Herholz, K, Kassiou, M, Crossman, D, Francis, S, Proctor, S D, Russell, J C, Hopkins, S J, Tyrrell, P J, Rothwell, N J & Allan, S M 2011, ' Brain inflammation is induced by co-morbidities and risk factors for stroke ', Brain, Behavior, and Immunity, vol. 25, no. 6, pp. 1113-1122 . < http://www.sciencedirect.com/science/article/pii/S0889159111000584 >
Brain, Behavior, and Immunity; Vol 25
Drake, C, Boutin, H, Jones, M S, Denes, A, McColl, B W, Selvarajah, J R, Hulme, S, Georgiou, R F, Hinz, R, Gerhard, A, Vail, A, Prenant, C, Julyan, P, Maroy, R, Brown, G, Smigova, A, Herholz, K, Kassiou, M, Crossman, D, Francis, S, Proctor, S D, Russell, J C, Hopkins, S J, Tyrrell, P J, Rothwell, N J & Allan, S M 2011, ' Brain inflammation is induced by co-morbidities and risk factors for stroke ', Brain, Behavior, and Immunity, vol. 25, no. 6, pp. 1113-1122 . < http://www.sciencedirect.com/science/article/pii/S0889159111000584 >
Highlights ► Risk factors for stroke include atherosclerosis, obesity, diabetes and hypertension. ► Stroke risk factors are associated with peripheral inflammation. ► Corpulent rats and atherogenic mice show increased inflammation in the brain.
Autor:
Albertine Dubois, Claude Comtat, Sébastien Jan, Renaud Maroy, Benoit Jego, Regine Trebossen, Raphaël Boisgard, Yoann Fontyn, Bertrand Tavitian
Publikováno v:
Medical Physics. 37:1507-1517
Purpose: Numerous new drug candidates fail because of inadequate pharmacokinetics. Positron emission tomography(PET) enables the noninvasive characterization of the drug in humans and animals. The aim of the present work was the comparison of methods
Autor:
Regine Trebossen, Claude Comtat, El Mostafa Fadaili, Renaud Maroy, Véronique Gaura, Antoine Souloumiac, Avner Bar-Hen, Maria Ribeiro, Paolo Zanotti-Fregonara, Sébastien Jan
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 29:1825-1835
The aim of this study was to compare eight methods for the estimation of the image-derived input function (IDIF) in [18F]-FDG positron emission tomography (PET) dynamic brain studies. The methods were tested on two digital phantoms and on four health
Autor:
Sébastien Jan, Claude Comtat, Renaud Maroy, Regine Trebossen, Paolo Zanotti-Fregonara, Véronique Gaura, Avner Bar-Hen, Maria Ribeiro
Publikováno v:
Journal of Nuclear Medicine. 50:461-467
Quantitative brain (18)F-FDG PET studies often require the plasma time-activity curve (input function) for estimation of the cerebral metabolic rate of glucose (CMRglc). The gold standard for input function measurement is arterial blood sampling, whi
Autor:
Christophe Champion, Elif Hindié, Jean Yves Devaux, Regine Trebossen, Renaud Maroy, Paolo Zanotti-Fregonara
Publikováno v:
Journal of Nuclear Medicine. 49:679-682
Although 18F-FDG examinations are widely used, data are lacking on the dose to human embryo tissues in cases of exposure in early pregnancy. Although the photon component can easily be estimated from available data on the pharmacokinetics of 18F-FDG
Autor:
Renaud Maroy, Katie N. Murray, Paul A. Jones, Alison Smigova, Jesús M. Pradillo, Hervé Boutin, Alexander Gerhard, William Trigg
Publikováno v:
Boutin, H, Murray, K, Pradillo, J, Maroy, R, Smigova, A, Gerhard, A, Jones, PA & Trigg, W 2015, ' 18F-GE-180: a novel TSPO radiotracer compared to 11C-R-PK11195 in a preclinical model of stroke ', European Journal of Nuclear Medicine and Molecular Imaging, vol. 42, no. 3, pp. 503-511 . https://doi.org/10.1007/s00259-014-2939-8
PURPOSE: Neuroinflammation plays a critical role in various neuropathological conditions, and hence there is renewed interest in the translocator protein (TSPO) as a biomarker of microglial activation and macrophage infiltration in the brain. This is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a0051c4fbdd4936ef6f9aea313290d
https://www.research.manchester.ac.uk/portal/en/publications/18fge180-a-novel-tspo-radiotracer-compared-to-11crpk11195-in-a-preclinical-model-of-stroke(1780a538-ff01-4a58-a8b0-945147b4c1c5).html
https://www.research.manchester.ac.uk/portal/en/publications/18fge180-a-novel-tspo-radiotracer-compared-to-11crpk11195-in-a-preclinical-model-of-stroke(1780a538-ff01-4a58-a8b0-945147b4c1c5).html