Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Renaud Lesourne"'
Publikováno v:
Biomedical Journal, Vol 45, Iss 2, Pp 334-346 (2022)
The activity of T cells is finely controlled by a set of negative regulators of T-cell antigen receptor (TCR)-mediated signaling. However, how those negative regulators are themselves controlled to prevent ineffective TCR-mediated responses remain po
Externí odkaz:
https://doaj.org/article/ad3bdb5d394f47cfa5987f9f32c3b1b0
Autor:
Jérémy Argenty, Nelly Rouquié, Cyrielle Bories, Suzanne Mélique, Valérie Duplan-Eche, Abdelhadi Saoudi, Nicolas Fazilleau, Renaud Lesourne
Publikováno v:
eLife, Vol 11 (2022)
The ability to proliferate is a common feature of most T-cell populations. However, proliferation follows different cell-cycle dynamics and is coupled to different functional outcomes according to T-cell subsets. Whether the mitotic machineries suppo
Externí odkaz:
https://doaj.org/article/6330498d833e40e4b8a8bde2320be539
Publikováno v:
Biomedical Journal. 45:334-346
The activity of T cells is finely controlled by a set of negative regulators of T-cell antigen receptor (TCR)-mediated signaling. However, how those negative regulators are themselves controlled to prevent ineffective TCR-mediated responses remain po
Autor:
Jérémy Argenty, Nelly Rouquié, Cyrielle Bories, Suzanne Mélique, Valérie Duplan-Eche, Abdelhadi Saoudi, Nicolas Fazilleau, Renaud Lesourne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d0941578171d8d6cd3136d9276f0c49
https://doi.org/10.7554/elife.80277.sa2
https://doi.org/10.7554/elife.80277.sa2
Autor:
Cui Yang, Gaëtan Blaize, Rémi Marrocco, Nelly Rouquié, Cyrielle Bories, Mylène Gador, Suzanne Mélique, Emeline Joulia, Mehdi Benamar, Anne S. Dejean, Hélène Daniels-Treffandier, Paul E. Love, Nicolas Fazilleau, Abdelhadi Saoudi, Renaud Lesourne
Publikováno v:
Science signaling. 15(742)
Signals that determine the differentiation of naïve CD4+T helper (TH) cells into specific effector cell subsets are primarily stimulated by cytokines, but additional signals are required to adjust the magnitude of THcell responses and set the balanc
Autor:
Ki-Duk Song, Hélène Daniels-Treffandier, Gaëtan Blaize, Meryem Aloulou, Anne Gonzalez de Peredo, Renaud Lesourne, Mylène Gador, Mariette F. Ducatez, Mehdi Benamar, Marlène Marcellin, Cui Yang, Nicolas Fazilleau, Abdelhadi Saoudi, Paul E. Love, Odile Burlet-Schiltz, Nelly Rouquié
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2020, 117 (23), pp.12969-12979. ⟨10.1073/pnas.1917182117⟩
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2020, 117 (23), pp.12969-12979. ⟨10.1073/pnas.1917182117⟩
CD5 is characterized as an inhibitory coreceptor with an important regulatory role during T cell development. The molecular mechanism by which CD5 operates has been puzzling and its function in mature T cells suggests promoting rather than repressing
Autor:
L. Aravind, Ekaterina Zvezdova, Jan Lee, Seeyoung Choi, Paul E. Love, Claude Warzecha, Renaud Lesourne, Jérémy Argenty
Publikováno v:
Nature Immunology. 18:433-441
THEMIS, a T cell-specific protein with high expression in CD4+CD8+ thymocytes, has a crucial role in positive selection and T cell development. THEMIS lacks defined catalytic domains but contains two tandem repeats of a distinctive module of unknown
Autor:
Renaud Lesourne, Tanya L. Crockford, Ekaterina Zvezdova, Marlène Marcellin, Delphine Baup, Daian Cheng, Richard J. Cornall, Katherine R. Bull, Mukta Deobagkar-Lele, Seeyoung Choi, Shoji Uehara, Paul E. Love, Claude Warzecha, Sophia C. Bennett, Consuelo Anzilotti, Anne Gonzalez de Peredo, Helen Ferry
Publikováno v:
Nature Immunology
Nature Immunology, Nature Publishing Group, 2017, 18 (2), pp.205-213. ⟨10.1038/ni.3642⟩
Nature Immunology, Nature Publishing Group, 2017, 18 (2), pp.205-213. ⟨10.1038/ni.3642⟩
The positive and negative selection of lymphocytes by antigen is central to adaptive immunity and self-tolerance, yet how this is determined by different antigens is not completely understood. We found that thymocyte-selection-associated family membe
Publikováno v:
Nature reviews. Immunology. 18(8)
The remarkable T cell receptor (TCR) performs essential functions in the initiation of intracellular signals required for T cell development, repertoire selection and effector responses to foreign antigens. How TCR signals elicit such diverse cellula
THEMIS, a recently identified T-lineage restricted protein, is the founding member of a large metazoan protein family. Gene inactivation studies have revealed a critical requirement for THEMIS during thymocyte positive selection, implicating THEMIS i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e22556adb1abdf2e648f64e5cdd61f2
https://doi.org/10.1016/j.it.2017.06.006
https://doi.org/10.1016/j.it.2017.06.006