Supplementary Figure S6 from Genetic Disruption of Lactate/H+ Symporters (MCTs) and Their Subunit CD147/BASIGIN Sensitizes Glycolytic Tumor Cells to Phenformin

Autor: Jacques Pouyssegur, Marie-Pierre Simon, Danièle Roux, Renaud Le Floch, Ibtissam Marchiq

Figure S6: Phenformin/MCT1 inhibition induces an increase in the ROS content and ROS scavengers do not rescue cell death.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3acd82dc51468fea935c6c229b0d5320
https://doi.org/10.1158/0008-5472.22406006.v1

Supplementary Figure S2 from Genetic Disruption of Lactate/H+ Symporters (MCTs) and Their Subunit CD147/BASIGIN Sensitizes Glycolytic Tumor Cells to Phenformin

Autor: Jacques Pouyssegur, Marie-Pierre Simon, Danièle Roux, Renaud Le Floch, Ibtissam Marchiq

Figure S2: Disruption of BSG, by zinc finger nucleases, reduces lactic acid transport, inhibits glycolysis and sensitizes U87 cells to the MCT1 inhibitor and phenformin.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f879290e2f6859a504a3a7a93581e8
https://doi.org/10.1158/0008-5472.22406018.v1

Supplementary Figure S1 from Genetic Disruption of Lactate/H+ Symporters (MCTs) and Their Subunit CD147/BASIGIN Sensitizes Glycolytic Tumor Cells to Phenformin

Autor: Jacques Pouyssegur, Marie-Pierre Simon, Danièle Roux, Renaud Le Floch, Ibtissam Marchiq

Figure S1: ZFN-mediated MCT4 and BSG gene knockout.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5a66481eed1334cd7490c1dcdafcc89
https://doi.org/10.1158/0008-5472.22406021.v1

Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status

Autor: Ibtissam Marchiq, Renaud Le Floch, Conceição Souto Moura, Sara Granja, Jacques Pouysségur, Fátima Baltazar

Publikováno v: Scopus-Elsevier
CIÊNCIAVITAE
Oncotarget
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Europe PubMed Central

Most cancers rely on aerobic glycolysis to generate energy and metabolic intermediates. To maintain a high glycolytic rate, cells must efficiently export lactic acid through the proton-coupled monocarboxylate transporters (MCT1/4). These transporters

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d261f1e1b5764d978cece1e2e2f0602e
https://doi.org/10.18632/oncotarget.2862

Genetic disruption of lactate/H+ symporters (MCTs) and their subunit CD147/BASIGIN sensitizes glycolytic tumor cells to phenformin

Autor: Jacques Pouysségur, Marie-Pierre Simon, Ibtissam Marchiq, Renaud Le Floch, Danièle Roux

Publikováno v: Cancer research. 75(1)

Rapidly growing glycolytic tumors require energy and intracellular pH (pHi) homeostasis through the activity of two major monocarboxylate transporters, MCT1 and the hypoxia-inducible MCT4, in intimate association with the glycoprotein CD147/BASIGIN (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c357a0578004a81db3afa0b04d06e4
https://pubmed.ncbi.nlm.nih.gov/25403912