Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Renaud, Morales"'
Autor:
Tony Rady, Stéphane Erb, Safia Deddouche-Grass, Renaud Morales, Guilhem Chaubet, Sarah Cianférani, Nicolas Basse, Alain Wagner
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109068- (2024)
Summary: Double-stranded RNAs (dsRNA)-based strategies appeared as promising therapies to induce an inflammation in the tumor microenvironment. However, currently described systems generally lack active targeting of tissues, and their clinical transl
Externí odkaz:
https://doaj.org/article/10ee33c87c4e491baeca79edaa602a6d
Autor:
Nicolas Muzet, Matthew Holderfield, Kanika Sharma, Eamonn Rooney, Bertrand Vivet, Renaud Morales, Christophe Marcireau, Ming Yi, Laurent Debussche, Frederic Lacroix, Walter Englaro, Julia Frappier, Dwight V. Nissley, Emilie Schell, Lick Pui Lai, Frank McCormick, Viviane Brel, Nicolas Basse, Nadia Le-Henanf
Publikováno v:
SLAS Discov
SLAS discovery : advancing life sciences R & D, vol 26, iss 7
SLAS discovery : advancing life sciences R & D, vol 26, iss 7
Oncogenic forms of KRAS proteins are known to be drivers of pancreatic, colorectal, and lung cancers. The goal of this study is to identify chemical leads that inhibit oncogenic KRAS signaling. We first developed an isogenic panel of mouse embryonic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf6c04fdb321a2d5f4df9c3ee736f2e
https://doi.org/10.1177/24725552211008853
https://doi.org/10.1177/24725552211008853
Autor:
Cyrielle Andouche, Nathalie Membré, Morgane Reynaud, Célia Halter, André Zimmermann, Nicolas Basse, Renaud Morales, Louison Lebrun, Felix Bärenz, Arnaud Hohwald, Safia Deddouche-Grass, Fabienne Weber, Matthieu Poirot, Nicolas Muzet, Rama Heng, Véronique Roujean
Publikováno v:
ACS Medicinal Chemistry Letters. 12:1137-1142
ERAP1 is a key aminopeptidase involved in peptide trimming before major histocompatibility complex (MHC) presentation. A single nucleotide polymorphism (SNP) in the ERAP1 gene can lead to impaired trimming activity and affect ERAP1 function. ERAP1 ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9050b2c6c4df33995347377adbd6f2f0
https://doi.org/10.1021/acsmedchemlett.1c00235
https://doi.org/10.1021/acsmedchemlett.1c00235
Autor:
Safia, Deddouche-Grass, Cyrielle, Andouche, Felix, Bärenz, Célia, Halter, Arnaud, Hohwald, Louison, Lebrun, Nathalie, Membré, Renaud, Morales, Nicolas, Muzet, Matthieu, Poirot, Morgane, Reynaud, Véronique, Roujean, Fabienne, Weber, André, Zimmermann, Rama, Heng, Nicolas, Basse
Publikováno v:
ACS Med Chem Lett
[Image: see text] ERAP1 is a key aminopeptidase involved in peptide trimming before major histocompatibility complex (MHC) presentation. A single nucleotide polymorphism (SNP) in the ERAP1 gene can lead to impaired trimming activity and affect ERAP1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::615f3ab598a9fddc16f08cfadff81769
https://pubmed.ncbi.nlm.nih.gov/34267884
https://pubmed.ncbi.nlm.nih.gov/34267884
Autor:
Alain Wagner, Dmitri Wiederschain, Renaud Morales, Hervé Bouchard, Nicolas Basse, Safia Deddouche-Grass, Tony Rady, Guilhem Chaubet, Sarah Cianférani, Stéphane Erb
Publikováno v:
Cancer Research. 81:691-691
Simultaneous access to several targets has become the subject of intense studies in immuno-oncology. In order to benefit from the synergies provided by the activation of different signaling pathways in immunology and the knockdown of proteins involve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::129c2f3ff244450087d5829c933519b3
https://doi.org/10.1158/1538-7445.am2021-691
https://doi.org/10.1158/1538-7445.am2021-691
Autor:
Nicolas Muzet, Matthew Holderfield, Julia Frappier, Renaud Morales, Christophe Marcireau, Eamonn Rooney, Frank McCormick, Dwight V. Nissley, Nadia Le-Henanf, Laurent Debussche, Frederic Lacroix, Walter Englaro, Kanika Sharma, Vivet Bertrand, Viviane Brel, Emilie Schell, Lick Pui Lai
Publikováno v:
Cancer Research. 80:6425-6425
The normal RAS signaling pathway provides a primary switch whereby cell proliferation is controlled through activation of RAS proteins and downstream signaling. Oncogenic mutants of RAS genes often drive hyper-activation of cell proliferation and sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff2b11d389b807566430fb6d5c2409a2
https://doi.org/10.1158/1538-7445.am2020-6425
https://doi.org/10.1158/1538-7445.am2020-6425
Autor:
Bodo Scheiper, Bernard Pessegue, Axel Ganzhorn, Christoph Pöverlein, Cédric Couturier, Sandra Silve, Eric Bacqué, Armin Bauer, Anil Nair, Renaud Morales, Sylvie Llopart, Sophie Lagrange
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:1455-1459
A series of imidazo[1,2-a]indeno[1,2-e]pyrazin-4-ones that potently inhibit M. tuberculosis glutamine synthetase (GlnA1) has been identified by high throughput screening. Exploration of this series was performed owing to a short chemistry program. De
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae9b3cfa07ea339bf3443a7b1877766
https://doi.org/10.1016/j.bmcl.2015.02.035
https://doi.org/10.1016/j.bmcl.2015.02.035
Autor:
Benoît Pinson, Irène Ceballos-Picot, Renaud Morales, Robert Barouki, Bertrand Daignan-Fornier, G.M. Pinon, Anne Olivier-Bandini, Françoise Chesney, Jessica Huyet, Franck Augé, Christelle Saint-Marc, Roland Lupoli, Abdul Rauf Siddiqi, Pierre Nioche, Mohammad Ozeir, Jean-Marc Remy, Jean-Francois Gibert, Marie-Claude Burgevin
Publikováno v:
Cell Chemical Biology
Cell Chemical Biology, Cell Press, 2018, 25 (6), pp.666-676.e4. ⟨10.1016/j.chembiol.2018.02.011⟩
Cell Chemical Biology, Cell Press, 2018, 25 (6), pp.666-676.e4. ⟨10.1016/j.chembiol.2018.02.011⟩
Summary Phosphoribosyltransferases catalyze the displacement of a PRPP α-1′-pyrophosphate to a nitrogen-containing nucleobase. How they control the balance of substrates/products binding and activities is poorly understood. Here, we investigated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd7c0c1339d7dfe2220644525a69f0c
https://pubmed.ncbi.nlm.nih.gov/29576532
https://pubmed.ncbi.nlm.nih.gov/29576532
Autor:
Cécile Delorme, Angela Virone-Oddos, Bernadette Tric, Audrey Louboutin, Fabienne Thompson, Christoph Lengauer, Loic Vincent, Nadine Michot, Isabelle Vade, Jean Paul Nicolas, Frank Halley, Youssef El-Ahmad, Bruno Filoche-Romme, Hélène Bonnevaux, Andreas Karlsson, Sylvie Monget, Renaud Morales, Victor Certal, Laurent Schio, Gilles Doerflinger, Sébastien Perron, Jean Christophe Carry, Pierre Yves Abecassis
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:6381-6384
From a HTS campaign, a new series of pyrimidone anilides exemplified by compound 1 has been identified with good inhibitory activity for the PI3Kβ isoform. The structure of compound 1 in PI3Kγ was solved revealing a binding mode in agreement with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a7ad294cd6eed46f1ac36681f76724
https://doi.org/10.1016/j.bmcl.2012.08.072
https://doi.org/10.1016/j.bmcl.2012.08.072
Publikováno v:
Journal of Molecular Biology. 421:100-111
Antibodies and prorenin mutants have long been used to structurally characterize prorenin, the inactive proenzyme form of renin. They were designed on the basis of homology models built using other aspartyl protease proenzyme structures since no stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23517e9add310d2d31ff6f01ff1b735a
https://doi.org/10.1016/j.jmb.2012.05.003
https://doi.org/10.1016/j.jmb.2012.05.003