Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Renatus W. Sinkeldam"'
Autor:
Renatus W, Sinkeldam, Yitzhak, Tor
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1973
A robust, fluorescence-based analysis and discovery platform is described for bacterial A-site binders. The assay relies on an incorporated isomorphic fluorescent uridine analog, which substitutes the A-site's U1406 and serves as a FRET donor to an A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2966be34c68abbe4231af10b294967a0
https://pubmed.ncbi.nlm.nih.gov/31016707
https://pubmed.ncbi.nlm.nih.gov/31016707
Autor:
Yitzhak Tor, Renatus W. Sinkeldam
Publikováno v:
Methods in Molecular Biology ISBN: 9781493992157
A robust, fluorescence-based analysis and discovery platform is described for bacterial A-site binders. The assay relies on an incorporated isomorphic fluorescent uridine analog, which substitutes the A-site's U1406 and serves as a FRET donor to an A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54978a5b7b51654b8d736941f6166a2f
https://doi.org/10.1007/978-1-4939-9216-4_16
https://doi.org/10.1007/978-1-4939-9216-4_16
Publikováno v:
Organic letters, vol 16, iss 20
Organic Letters
Organic Letters
A family of extended 5-modified-6-aza-uridines was obtained via Suzuki coupling reactions with a common brominated precursor. Extending the conjugated-6-aza-uridines with substituted aryl rings increases the push-pull interactions yielding enhanced b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3991586aeb4e70abf25efc617f0e384
https://doi.org/10.1021/ol502435d
https://doi.org/10.1021/ol502435d
Publikováno v:
Angewandte Chemie (International ed. in English), vol 52, iss 52
Adenosine deaminase, a major enzyme involved in purine metabolism, converts an isomorphic fluorescent analogue of adenosine (thA) to an isomorphic inosine analogue (thI), which possesses distinct spectral features, allowing one to monitor the enzyme-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b126504cba005b0a0440a7e663896697
https://doi.org/10.1002/anie.201307064
https://doi.org/10.1002/anie.201307064
Autor:
Renatus W. Sinkeldam, Yitzhak Tor
Publikováno v:
Fluorescent Analogues of Biomolecular Building Blocks: Design and Applications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee42ba38b3900a6714c41bf8d250831b
https://doi.org/10.1002/9781119179320.ch2
https://doi.org/10.1002/9781119179320.ch2
Autor:
Renatus W. Sinkeldam, Yitzhak Tor
Publikováno v:
Fluorescent Analogues of Biomolecular Building Blocks: Design and Applications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2e3b9967fe02a0a639e41a9ae49b3d8
https://doi.org/10.1002/9781119179320.ch12
https://doi.org/10.1002/9781119179320.ch12
Publikováno v:
ChemPhysChem. 13:3350-3356
Optimized facile syntheses and highly desirable spectroscopic properties of two isomorphic fluorescent pyrimidines, comprising a 1,2,4-triazine motif conjugated to a thiophene (1 a) or a furan (1 b), are described. Although structurally related to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a6830dcabe02025eee9fe5033902f9
https://doi.org/10.1002/cphc.201200375
https://doi.org/10.1002/cphc.201200375
Publikováno v:
Journal of the American Chemical Society. 133:14912-14915
A fluorescent ribonucleoside alphabet consisting of highly emissive purine ((th)A, (th)G) and pyrimidine ((th)U, (th)C) analogues, all derived from thieno[3,4-d]pyrimidine as the heterocyclic nucleus, is described. Structural and biophysical analyses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaee507709c9db37231afbc4189a1561
https://doi.org/10.1021/ja206095a
https://doi.org/10.1021/ja206095a
Publikováno v:
ChemPhysChem. 12:567-570
Naturally occurring nucleosides, the building blocks of nucleic acids, are characterized by two distinct molecular elements: a rigid aromatic nucleobase and a more flexible (2’-deoxy)-d-ribose moiety. The structural features of nucleosides and thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::881a5b3e3db0cde508bd025260403d57
https://doi.org/10.1002/cphc.201001002
https://doi.org/10.1002/cphc.201001002
Autor:
Pim G. A. Janssen, Renatus W. Sinkeldam, Joost L. J. van Dongen, Wouter van Houts, E. W. Meijer, Xianwen Lou, Yohann Nicolas, Jef A. J. M. Vekemans
Publikováno v:
Journal of Mass Spectrometry, 42(3), 293-303. Wiley
Six anthraquinone derivatives were analyzed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI TOF MS). Clear (pseudo) molecular ions were observed for all the compounds. Interestingly, for some derivatives, str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ccaa5016192a30042f104198de4c4b
https://doi.org/10.1002/jms.1161
https://doi.org/10.1002/jms.1161