Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Renato Wirthner"'
The histone variant 2AX (H2AX) is phosphorylated at Serine 139 by the PI3K-like kinase family members ATM, ATR and DNA-PK. Genotoxic stress, such as tumor radio- and chemotherapy, is considered to be the main inducer of phosphorylated H2AX (γH2AX),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb72cb166791ac065f912825abc90859
http://doc.rero.ch/record/290821/files/hsz-2012-0311.pdf
http://doc.rero.ch/record/290821/files/hsz-2012-0311.pdf
Autor:
Roland H. Wenger, Renato Wirthner, Gieri Camenisch, Daniel P. Stiehl, Jens Köditz, Patrick Spielmann
Publikováno v:
Journal of Biological Chemistry. 281:23482-23491
Prolyl 4-hydroxylase domain (PHD) proteins are oxygen-dependent enzymes that hydroxylate hypoxia-inducible transcription factor (HIF) alpha-subunits, leading to their subsequent ubiquitination and degradation. Paradoxically, the expression of two fam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24b0d349901884c7c5e6c04f56147d1a
https://doi.org/10.1074/jbc.m601719200
https://doi.org/10.1074/jbc.m601719200
Autor:
Renato Wirthner, Dörthe M. Katschinski, Nadia O. Ibrahim, Corinna Franke, Daniel P. Stiehl, Torsten Hahn, Roland H. Wenger
Publikováno v:
Cancer Research. 65:11094-11100
The heterodimeric hypoxia-inducible factor-1 (HIF-1) is involved in key steps of tumor progression and therapy resistance and thus represents an attractive antitumor target. Because heat shock protein 90 (HSP90) plays an important role in HIF-1α pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c35ce12b59048a6b06922c45802de218
https://doi.org/10.1158/0008-5472.can-05-1877
https://doi.org/10.1158/0008-5472.can-05-1877
Publikováno v:
Carcinogenesis. 29(12)
A mismatch between metabolic demand and oxygen delivery leads to microenvironmental changes in solid tumors. The resulting tumor hypoxia is associated with malignant progression, therapy resistance and poor prognosis. However, the molecular mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a12d0ca6d7dd63e132c29e8902f4e86e
https://pubmed.ncbi.nlm.nih.gov/18842680
https://pubmed.ncbi.nlm.nih.gov/18842680
Autor:
Renato, Wirthner, Kuppusamy, Balamurugan, Daniel P, Stiehl, Sandra, Barth, Patrick, Spielmann, Felix, Oehme, Ingo, Flamme, Dörthe M, Katschinski, Roland H, Wenger, Gieri, Camenisch
Publikováno v:
Methods in enzymology. 435
The prolyl-4-hydroxylase domain (PHD) oxygen sensor proteins hydroxylate hypoxia-inducible transcription factor (HIF)-alpha (alpha) subunits, leading to their subsequent ubiquitinylation and degradation. Since oxygen is a necessary cosubstrate, a red
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cda0b7430a4878664d7b905c6582f07e
https://pubmed.ncbi.nlm.nih.gov/17998048
https://pubmed.ncbi.nlm.nih.gov/17998048
Autor:
Jutta Nesper, Renato Wirthner, Daniel P. Stiehl, Frank Edlich, Gieri Camenisch, Philippe A. Hasgall, Katarzyna J. Nytko, Sandra Barth, Dörthe M. Katschinski, Roland H. Wenger
The heterodimeric hypoxia-inducible transcription factors (HIFs) are central regulators of the response to low oxygenation. HIF-alpha subunits are constitutively expressed but rapidly degraded under normoxic conditions. Oxygen-dependent hydroxylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d73bb7cf0e5f580406b19c6f067d467
https://europepmc.org/articles/PMC1899990/
https://europepmc.org/articles/PMC1899990/
Autor:
Dörthe M. Katschinski, Sandra Barth, Kuppusamy Balamurugan, Ingo Flamme, Gieri Camenisch, Daniel P. Stiehl, Renato Wirthner, Felix Oehme, Roland H. Wenger, Patrick Spielmann
The prolyl-4-hydroxylase domain (PHD) oxygen sensor proteins hydroxylate hypoxia-inducible transcription factor (HIF)-alpha (alpha) subunits, leading to their subsequent ubiquitinylation and degradation. Since oxygen is a necessary cosubstrate, a red
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea24952be5111513bae9e6a4e984879c
https://doi.org/10.1016/s0076-6879(07)35003-9
https://doi.org/10.1016/s0076-6879(07)35003-9
Autor:
Daniel P, Stiehl, Renato, Wirthner, Jens, Köditz, Patrick, Spielmann, Gieri, Camenisch, Roland H, Wenger
Publikováno v:
The Journal of biological chemistry. 281(33)
Prolyl 4-hydroxylase domain (PHD) proteins are oxygen-dependent enzymes that hydroxylate hypoxia-inducible transcription factor (HIF) alpha-subunits, leading to their subsequent ubiquitination and degradation. Paradoxically, the expression of two fam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c042f535a4f51e24b0e187cdfbd9775e
https://pubmed.ncbi.nlm.nih.gov/16790428
https://pubmed.ncbi.nlm.nih.gov/16790428
Publikováno v:
ChemInform. 34
Hydrolysis of N-benzyloxycarbonyl-3,4-epoxy-pyrrolidine and cyclohexene oxide with the epoxide hydrolase of Sphingomonas sp. HXN-200, respectively, gave the corresponding vicinal trans-diols in high ee and yield, representing the first example of ena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e75e20480b03c0c2de01c0846bdf5d
https://doi.org/10.1002/chin.200330047
https://doi.org/10.1002/chin.200330047
Publikováno v:
Carcinogenesis; Dec2008, Vol. 29 Issue 12, p2306-2306, 1p