Výsledky vyhledávání - "Renato M. S. Cardoso"

Akademický článek

Development of an optimized and scalable method for isolation of umbilical cord blood‐derived small extracellular vesicles for future clinical use

Autor: Renato M. S. Cardoso, Silvia C. Rodrigues, Claudia F. Gomes, Filipe V. Duarte, Maryse Romao, Ermelindo C. Leal, Patricia C. Freire, Ricardo Neves, Joana Simões‐Correia

Publikováno v: Stem Cells Translational Medicine, Vol 10, Iss 6, Pp 910-921 (2021)

Abstract Extracellular vesicles (EV) are a promising therapeutic tool in regenerative medicine. These particles were shown to accelerate wound healing, through delivery of regenerative mediators, such as microRNAs. Herein we describe an optimized and

Externí odkaz: https://doaj.org/article/e1f2c32bd9914a6886fa4ef15b781b83

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Akademický článek

Toxicological Profile of Umbilical Cord Blood-Derived Small Extracellular Vesicles

Autor: Silvia C. Rodrigues, Renato M. S. Cardoso, Claudia F. Gomes, Filipe V. Duarte, Patricia C. Freire, Ricardo Neves, Joana Simoes-Correia

Publikováno v: Membranes, Vol 11, Iss 9, p 647 (2021)

The development and adoption of cell therapies has been largely limited by difficulties associated with their safety, handling, and storage. Extracellular vesicles (EV) have recently emerged as a likely mediator for the therapeutic effect of cells, o

Externí odkaz: https://doaj.org/article/576b17b2823240f7b36ceee84f8e1a35

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Akademický článek

Mitochondrial microRNAs: A Putative Role in Tissue Regeneration

Autor: Sílvia C. Rodrigues, Renato M. S. Cardoso, Filipe V. Duarte

Publikováno v: Biology, Vol 9, Iss 12, p 486 (2020)

The most famous role of mitochondria is to generate ATP through oxidative phosphorylation, a metabolic pathway that involves a chain of four protein complexes (the electron transport chain, ETC) that generates a proton-motive force that in turn drive

Externí odkaz: https://doaj.org/article/b4849318d0c5444e9859403c6735bafc

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Immunomodulatory Properties of Umbilical Cord Blood-Derived Small Extracellular Vesicles and Their Therapeutic Potential for Inflammatory Skin Disorders

Autor: Filipe V. Duarte, Silvia C Rodrigues, Claudia F Gomes, Renato M. S. Cardoso, Joana Simões-Correia, Patricia C. Freire, Ricardo Pires das Neves

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 9797, p 9797 (2021)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
International Journal of Molecular Sciences
Volume 22
Issue 18

Umbilical cord blood (UCB) has long been seen as a rich source of naïve cells with strong regenerative potential, likely mediated by small extracellular vesicles (sEV). More recently, small extracellular vesicles (sEV), such as exosomes, have been s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bec92ae530fda1dbe819777ba4bf147
https://www.mdpi.com/1422-0067/22/18/9797

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Toxicological Profile of Umbilical Cord Blood-Derived Small Extracellular Vesicles

Autor: Filipe V. Duarte, Silvia C Rodrigues, Claudia F Gomes, Joana Simões-Correia, Ricardo Pires das Neves, Patricia C. Freire, Renato M. S. Cardoso

Publikováno v: Membranes
Membranes, Vol 11, Iss 647, p 647 (2021)
Volume 11
Issue 9

The development and adoption of cell therapies has been largely limited by difficulties associated with their safety, handling and storage. Extracellular vesicles (EV) have recently emerged as a likely mediator for the therapeutic effect of cells, of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb35e54eecc21153cf274c14becd08b5
https://pubmed.ncbi.nlm.nih.gov/34564463

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The Kinetics of Small Extracellular Vesicle Delivery Impacts Skin Tissue Regeneration

Autor: Helena Henriques-Antunes, Ivana Kostic, Lino Ferreira, Célia Gomes, Renato M. S. Cardoso, Miguel M. Lino, Adrian Jiménez-Balsa, Joana Correia, Eugenia Carvalho, Jeffrey M. Karp, Ana M.C. Barradas, Alessandra Zonari, Ermelindo C. Leal

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
ACS Nano

Small extracellular vesicles (SEVs) offer a promising strategy for tissue regeneration, yet their short lifetime at the injured tissue limits their efficacy. Here, we show that kinetics of SEV delivery impacts tissue regeneration at tissue, cellular,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef8a9070cbc0d11851ac387405b19a6
https://doi.org/10.1021/acsnano.9b00376

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Mitochondrial microRNAs: A Putative Role in Tissue Regeneration

Autor: Filipe V. Duarte, Silvia C Rodrigues, Renato M. S. Cardoso

Publikováno v: Biology, Vol 9, Iss 486, p 486 (2020)
Biology

Simple Summary Distinct tissue engineering strategies are currently being developed. Cell-based therapies, implantation of synthetic scaffolds or combination of a scaffold with seeded cells are being used according to the biologic premises. Mitochond

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80d7d35c6f53c415204d297e622c7492
https://www.mdpi.com/2079-7737/9/12/486

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Molecular crowding effects on the distribution of amphiphiles in biological media

Autor: Patrícia A.T. Martins, Tiago Palmeira, Jaime Samelo, Maria João Moreno, Ana Maria Alves, Renato M. S. Cardoso, Cristiana L. Pires, Neuza Domingues, Adrián Velázquez-Campoy

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

7 pags., 8 figs.
Biological systems are the result of the interactions established among their many distinct molecules and molecular assemblies. The high concentration of small molecules dissolved in the aqueous media alter the water properties

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2790ff794256cef79a8b9ebdfcc9e958
http://hdl.handle.net/10261/206490

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Effect of dipole moment on amphiphile solubility and partition into liquid ordered and liquid disordered phases in lipid bilayers

Autor: Patrícia A.T. Martins, Kalbe Razi Naqvi, Ricardo J. B. Leote, Renato M. S. Cardoso, Maria João Moreno, Margarida M. Cordeiro, Winchil L.C. Vaz, Cristiana V. Ramos

Publikováno v: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1862:183157

Association of amphiphiles with biomembranes is important for their availability at specific locations in organisms and cells, being critical for their biological function. A prominent role is usually attributed to the hydrophobic effect, and to elec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c9432cd657398e42e9ef20452b2ec33
https://doi.org/10.1016/j.bbamem.2019.183157

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Chain-Length Dependence of Insertion, Desorption, and Translocation of a Homologous Series of 7-Nitrobenz-2-oxa-1,3-diazol-4-yl-Labeled Aliphatic Amines in Membranes

Autor: Filipe Gomes, Patrícia A.T. Martins, Maria João Moreno, Slavomira Doktorovova, Winchil L.C. Vaz, Renato M. S. Cardoso

Publikováno v: The Journal of Physical Chemistry B. 115:10098-10108

We present a complete characterization of the kinetics of interaction between the homologous series of fluorescent fatty amines with the fluorescent moiety 7-nitrobenz-2-oxa-1,3-diazol-4-yl covalently bound to the amine group, NBD-C(n) (n = 8-16), an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8326d88534f41e10903078d072253b
https://doi.org/10.1021/jp203429s

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