Anti-citrullinated histone monoclonal antibody CIT-013, a dual action therapeutic for neutrophil extracellular trap-associated autoimmune diseases

Autor: Maarten van der Linden, Sangeeta Kumari, Daphne Montizaan, Stephanie van Dalen, Annemarie Kip, Martyn Foster, Inge Reinieren-Beeren, Elsa Neubert, Luise Erpenbeck, Kelsy Waaijenberg, Tirza Bruurmijn, Rezie te Poele, Peter van Zandvoort, Paul Vink, Eric Meldrum, Helmuth van Es, Renato G.S. Chirivi

Publikováno v: mAbs, Vol 15, Iss 1 (2023)

ABSTRACTNeutrophil extracellular traps (NETs) contribute to the pathophysiology of multiple inflammatory and autoimmune diseases. Targeting the NETosis pathway has demonstrated significant therapeutic potency in various disease models. Here, we descr

Externí odkaz: https://doaj.org/article/f1d4fae7078645b59627f1f002b651f7

Therapeutic ACPA inhibits NET formation: a potential therapy for neutrophil-mediated inflammatory diseases

Autor: Helmuth H. G. van Es, Konstantinos Kambas, Gonny Schmets, Renato G.S. Chirivi, Jos W. G. van Rosmalen, Markus H. Hoffmann, Jos M.H. Raats, Maarten van der Linden, Quinte Braster, Galina S. Bogatkevich, Jonas Hahn, Maximilien Euler, Oliver Soehnlein

Publikováno v: Cellular and Molecular Immunology
Cellular & molecular immunology, 18(6). Nature Publishing Group

Excessive release of neutrophil extracellular traps (NETs) is associated with disease severity and contributes to tissue injury, followed by severe organ damage. Pharmacological or genetic inhibition of NET release reduces pathology in multiple infla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc389ee30b29138d7bddf35dd403057
https://doi.org/10.1038/s41423-020-0381-3

Recombinant antibody against Trypanosoma cruzi from patients with chronic Chagas heart disease recognizes mammalian nervous system

Autor: Guillermo D. Alonso, Micaela S. Ossowski, Karina A. Gómez, Maria May, Vanina Grippo, Leandro Simonetti, Marcelo A. Comini, Mariana Potenza, Renato G.S. Chirivi, Jos M.H. Raats, Carlos Robello, Leticia L. Niborski, Adriana Parodi-Talice, Daniela I. Staquicini

Publikováno v: COLIBRI
Universidad de la República
instacron:Universidad de la República
EBioMedicine
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
EBioMedicine, Vol 63, Iss, Pp 103206-(2021)

Background: To deeply understand the role of antibodies in the context of Trypanosoma cruzi infection, we decided to characterize A2R1, a parasite antibody selected from single-chain variable fragment (scFv) phage display libraries constructed from B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc496020f7ccca179b59b26ae112e8f
https://doi.org/10.1016/j.ebiom.2020.103206

Citrullination: A target for disease intervention in multiple sclerosis and other inflammatory diseases?

Autor: Ger J. M. Pruijn, Guido J. Jenniskens, Jos W. G. van Rosmalen, Renato G.S. Chirivi, Jos M.H. Raats

Publikováno v: Journal of Clinical & Cellular Immunology, 4, 1-8
Journal of Clinical & Cellular Immunology, 4, 3, pp. 1-8

Citrullinated histone epitopes are involved in the very early stages of inflammatory responses. An important early event is the activation of neutrophils. It has been shown that Peptidyl Arginine Deiminase (PAD) expression levels increase upon pro-in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75963318c5abf690ab5aacae9886fe2
http://hdl.handle.net/2066/123057

OP0148 First in Class Therapeutic Acpa Reduces Inflammation by Inhibition of Netosis

Autor: J.W. van Rosmalen, Es H. van, Renato G.S. Chirivi, G. Schmets, Jos M.H. Raats

Publikováno v: Annals of the Rheumatic Diseases. 75:112.2-112

Background Neutrophils together with aberrant Neutrophil Extracellular Trap (NET) formation contribute to the induction and propagation of inflammation. A growing number of studies indicate that Peptidyl Arginine Deiminases (PADs) mediated conversion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64b0cbed638447ada49ebfab73d92c88
https://doi.org/10.1136/annrheumdis-2016-eular.1376