Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Renato B. Del Rosario"'
Autor:
Donald M. Wieland, Yong Woon Jung, Renato B. Del Rosario, Pulak K. Chakraborty, John M. Caraher
Publikováno v:
Nuclear Medicine and Biology. 23:611-616
The in vivo behavior of (-)-[11C]phenylephrine (PHEN) is compared with the structurally similar but monoamine oxidase (MAO)-resistant analog (-)-[11C]-m-hydroxyephedrine (HED), which is an established heart neuronal marker. The chiral synthesis of PH
Autor:
Yong-Woon Jung, David M. Raffel, Renato B. Del Rosario, and David L. Gildersleeve, Donald M. Wieland, G. Keith Mulholland, Phillip S. Sherman, David E. Kuhl, Marcian E. Van Dort, Kirk A. Frey
Publikováno v:
Journal of Medicinal Chemistry. 39:3331-3342
Alzheimer's disease is characterized by progressive cerebral cholinergic neuronal degeneration. Radiotracer analogs of benzovesamicol, which bind with high affinity to the vesamicol receptor located on the uptake transporter of acetylcholine storage
Publikováno v:
International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology. 19:417-421
Disulfide links of the IgG2ak anti-ovarian carcinoma antibody, 5G6.4, were site-specifically biotinylated [approximately 2 biotins/IgG2a] using a novel crosslinking procedure using the biotin derivatized ETAC (equilibrium transfer alkylation crosslin
Autor:
Stephen J. Brocchini, Richard G. Lawton, Richard L. Wahl, Richard H. Smith, Renato B. Del Rosario
Publikováno v:
Bioconjugate Chemistry. 1:51-59
The site-specific intramolecular cross-linking of sulfhydryls of monoclonal antibodies via a new class of "equilibrium transfer alkylation cross-link (ETAC) reagents" is described. Following complete or partial reduction of interchain disulfides with
Autor:
Thomas J. Mangner, David L. Gildersleeve, John A. Lowe, R. Michael Snider, Paul D. Shreve, Susan E. Drozda, Renato B. Del Rosario, Donald M. Wieland
Publikováno v:
Nuclear Medicine and Biology. 20:545-547
CP 96,345 is a nonpeptide high affinity antagonist of the substance P (NK1) receptor. The radiosynthesis of [11C]CP 96,345 suitable for Positron Emission Tomography (PET) applications is described. [11C]CP 96,345 was prepared by O-methylation of a de
Publikováno v:
Nuclear medicine and biology. 21(2)
The diaminodithiol (DADT) ligand has been conjugated to the neuromuscular blocking agent benzovesamicol (BVM) in the 5-position. DADT-BVM 1 was synthesized by coupling of 5-aminomethylbenzovesamicol with a BCA thiolactone reagent. 99m Tc radiolabelin
Autor:
Renato B. Del Rosario, Richard L. Wahl
Publikováno v:
International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology. 16:525-529
Sulfhydryl groups of a murine IgG2a monoclonal antibody, 5G6.4, were site-specifically biotinylated with N -iodo-acetyl- N′ -biotinylhexylenediamine (compound 1) following partial reduction of disulfide bonds. Antibody labeling using fluoresceinate