Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin

Autor: Doris Hellerschmied, Anita Lehner, Nina Franicevic, Renato Arnese, Chloe Johnson, Antonia Vogel, Anton Meinhart, Robert Kurzbauer, Luiza Deszcz, Linn Gazda, Michael Geeves, Tim Clausen

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Myosin, a motor protein essential for intracellular transport to muscle contraction, requires a chaperone UNC-45 for folding and assembly. Here authors use in vitro reconstitution and structural biology to characterize the interplay between UNC-45 an

Externí odkaz: https://doaj.org/article/988d6ef9a9a34ef79788fa29755892f7

Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin

Autor: Antonia Vogel, Luiza Deszcz, Anton Meinhart, Tim Clausen, Robert Kurzbauer, Linn Gazda, Doris Hellerschmied, Michael A. Geeves, Chloe A. Johnson, Nina Franicevic, Renato Arnese, Anita Lehner

Publikováno v: Nature Communications
'Nature Communications ', vol: 10, pages: 4781-1-4781-14 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications 10(1), 4781 (2019). doi:10.1038/s41467-019-12667-8

Myosin is a motor protein that is essential for a variety of processes ranging from intracellular transport to muscle contraction. Folding and assembly of myosin relies on a specific chaperone, UNC-45. To address its substrate-targeting mechanism, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfff0c0acff011837f4c324acd625e5e
https://kar.kent.ac.uk/77825/1/s41467-019-12667-8.pdf

UNC-45 assisted myosin folding depends on a conserved FX3HY motif implicated in Freeman Sheldon Syndrome.

Autor: Vogel, Antonia, Arnese, Renato, Gudino Carrillo, Ricardo M., Sehr, Daria, Deszcz, Luiza, Bylicki, Andrzej, Meinhart, Anton, Clausen, Tim

Publikováno v: Nature Communications; 7/25/2024, Vol. 15 Issue 1, p1-14, 14p

New Freeman-Sheldon Syndrome Study Findings Have Been Published by Researchers at Research Institute of Molecular Pathology (UNC-45 assisted myosin folding depends on a conserved FX3HY motif implicated in Freeman Sheldon Syndrome).

Publikováno v: Genomics & Genetics Weekly; 8/16/2024, p957-957, 1p

Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin.

Autor: Hellerschmied, Doris, Lehner, Anita, Franicevic, Nina, Arnese, Renato, Johnson, Chloe, Vogel, Antonia, Meinhart, Anton, Kurzbauer, Robert, Deszcz, Luiza, Gazda, Linn, Geeves, Michael, Clausen, Tim

Publikováno v: Nature Communications; 10/21/2019, Vol. 10 Issue 1, pN.PAG-N.PAG, 1p