Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Renate Schottmann"'
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Akademický článek
Synergistic activity of IDH1 inhibitor BAY1436032 with azacitidine in IDH1 mutant acute myeloid leukemia
Autor: Anuhar Chaturvedi, Charu Gupta, Razif Gabdoulline, Nora M. Borchert, Ramya Goparaju, Stefan Kaulfuss, Kerstin Görlich, Renate Schottmann, Basem Othman, Julia Welzenbach, Olaf Panknin, Markus Wagner, Robert Geffers, Arnold Ganser, Felicitas Thol, Michael Jeffers, Andrea Haegebarth, Michael Heuser
Publikováno v: Haematologica, Vol 106, Iss 2 (2020)
Mutant IDH1 (mIDH1) inhibitors have shown single-agent activity in relapsed/refractory AML, though most patients eventually relapse. We evaluated the efficacy and molecular mechanism of the combination treatment with azacitidine, which is currently t
Externí odkaz: https://doaj.org/article/64b0bb93a8d94cbca64e4eba9c21cc0f
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2
In vivo efficacy of mutant IDH1 inhibitor HMS-101 and structural resolution of distinct binding site
Autor: Arnold Kloos, Kerstin Goerlich, Eduard A. Struys, Michelle Maria Araujo Cruz, Denis Grote-Koska, Julia Weder, Basem Othman, Thomas Klünemann, Charu Gupta, Arnold Ganser, Anuhar Chaturvedi, Ramya Goparaju, Matthias Preller, Heike Bähre, Michael Heuser, Renate Schottmann, Korbinian Brand
Publikováno v: Chaturvedi, A, Goparaju, R, Gupta, C, Weder, J, Klünemann, T, Araujo Cruz, M M, Kloos, A, Goerlich, K, Schottmann, R, Othman, B, Struys, E A, Bähre, H, Grote-Koska, D, Brand, K, Ganser, A, Preller, M & Heuser, M 2020, ' In vivo efficacy of mutant IDH1 inhibitor HMS-101 and structural resolution of distinct binding site ', Leukemia, vol. 34, no. 2, pp. 416-426 . https://doi.org/10.1038/s41375-019-0582-x
Leukemia, 34(2), 416-426. Nature Publishing Group
Leukemia
Mutations in isocitrate dehydrogenase 1 (IDH1) are found in 6% of AML patients. Mutant IDH produces R-2-hydroxyglutarate (R-2HG), which induces histone- and DNA-hypermethylation through the inhibition of epigenetic regulators, thus linking metabolism
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca74d563472075d774da344fc2f4a3d1
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85074391501&origin=inward
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3
Effective drug treatment identified by in vivo screening in a transplantable patient-derived xenograft model of chronic myelomonocytic leukemia
Autor: Arnold Ganser, Lina Winckler, Axel Schambach, Felicitas Thol, Adrian Schwarzer, Charu Gupta, Konstantinos Mintzas, Nidhi Jyotsana, Suzan Imren, R. Keith Humphries, Nadine Kattre, Arnold Kloos, Michael Heuser, Felix F. Adams, Razif Gabdoulline, Renate Schottmann, Dirk Heckl, Michaela Scherr, Yasmine Alwie
Publikováno v: Leukemia
To establish novel and effective treatment combinations for chronic myelomonocytic leukemia (CMML) preclinically, we hypothesized that supplementation of CMML cells with the human oncogene Meningioma 1 (MN1) promotes expansion and serial transplantab
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16a9571a188903a9ff1396c3f5f7cc22
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5
Enantiomer-specific and paracrine leukemogenicity of mutant IDH metabolite 2-hydroxyglutarate
Autor: Carsten Müller-Tidow, Adrian Schwarzer, M.M. Araujo Cruz, Anuhar Chaturvedi, Ramya Goparaju, Gudrun Göhring, Nidhi Jyotsana, Amar Deep Sharma, Robert Geffers, Renate Schottmann, Michael Heuser, Arnold Ganser, Erwin E.W. Jansen, Felicitas Thol, Eduard A. Struys, Kerstin Görlich, Christian Rohde
Publikováno v: Leukemia, 30(8), 1708-1715. Nature Publishing Group
Chaturvedi, A, Cruz, M M A, Jyotsana, N, Sharma, A, Goparaju, R, Schwarzer, A, Goerlich, K, Schottmann, R, Struijs, E, Jansen, E E, Rohde, C, Mueller-Tidow, C, Geffers, R, Goehring, G, Ganser, A, Thol, F & Heuser, M 2016, ' Enantiomer-specific and paracrine leukemogenicity of mutant IDH metabolite 2-hydroxyglutarate ', Leukemia, vol. 30, no. 8, pp. 1708-1715 . https://doi.org/10.1038/leu.2016.71
Leukemia
Canonical mutations in IDH1 and IDH2 produce high levels of the R-enantiomer of 2-hydroxyglutarate (R-2HG), which is a competitive inhibitor of α-ketoglutarate (αKG)-dependent enzymes and a putative oncometabolite. Mutant IDH1 collaborates with Hox
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37aabe92b9d52182ee4c9f6c8ae5dccf
https://doi.org/10.1038/leu.2016.71
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Targeted Inhibition of the NUP98-NSD1 Fusion Oncogene in Acute Myeloid Leukemia
Autor: Euan Ramsay, Arnold Kloos, Felicitas Thol, Anitha Thomas, Florian Grebien, Nidhi Jyotsana, Amit Sharma, Hans-Peter Vornlocher, Sagarajit Mohanty, Johannes Schmoellerl, Michael Heuser, Madhvi Mandhania, Basem Othman, Courteney K. Lai, Arnold Ganser, Razif Gabdoulline, Renate Schottmann
Publikováno v: Cancers
Volume 12
Issue 10
Cancers, Vol 12, Iss 2766, p 2766 (2020)
Simple Summary NUP98-NSD1-positive acute myeloid leukemia (AML) frequently shows an additional mutation in Neuroblastoma rat sarcoma (NRAS). However, the synergistic effect of NUP98-NSD1 and NRASG12D in leukemic transformation remained unclear. In ad
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cadde40fbee4fd56cc63afc0a130e9c2
https://doi.org/10.3390/cancers12102766
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7
Efficacy of Chemotherapy, Phd-Inhibitor Molidustat or BRD4 Inhibitor JQ1 in Combination with Targeted Inhibition of Mutated IDH1 in Human AML In Vivo
Autor: Markus Wagner, Michael Jeffers, Olaf Panknin, Kerstin Görlich, Michael Heuser, Renate Schottmann, Basem Othman, Andrea Haegebarth, Arnold Ganser, Stefan Kaulfuss, Charu Gupta, Anuhar Chaturvedi
Publikováno v: Blood. 134:3933-3933
Background: Approximately 40% of AML patients with IDH1 mutation respond to monotherapy with the IDH1 inhibitor ivosidenib with a median duration of response of 8.2 months, suggesting that IDH1 inhibitors should be rationally combined with other agen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4cf9d4d4c60ea580b6d7638160c29c7
https://doi.org/10.1182/blood-2019-124016
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8
Functional Screening for Pathways Regulating Chemoresistance and Sensitivity in Leukemia Stem Cells
Autor: Simon Danisch, Renata Stripecke, Felicitas Thol, Michael Heuser, Arnold Kloos, Razif Gabdoulline, Renate Schottmann, Konstantinos Mintzas, Arnold Ganser
Publikováno v: Blood. 132:3933-3933
INTRODUCTION On average 5 recurrent mutations are present in each patient with acute myeloid leukemia (AML). Many mutated genes are implicated as tumor suppressor genes, but their contribution to leukemia stem cell (LSC) survival and chemoresistance
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d1856d6002f53375e6444ba12c7bd44
https://doi.org/10.1182/blood-2018-99-112373
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9
Prolyl Hydroxylase 3 (Phd3) Is a Therapeutic Target in Isocitrate Dehydrogenase 1 (IDH1) Mutated Acute Myeloid Leukemia
Autor: Renate Schottmann, Peter Carmeliet, Anuhar Chaturvedi, Michelle Maria Araujo Cruz, Felicitas Thol, Ramya Goparaju, Arnold Kloos, Arnold Ganser, Michael Heuser, Kerstin Görlich, Dimitrios Mougiakakos, Razif Gabdoulline, Robert Geffers
Publikováno v: Blood. 132:759-759
Background: About 40% of IDH1 mutated (IDH1mut) acute myeloid leukemia (AML) patients respond to IDH1 inhibitors with a median duration of response of 8.2 months. A better understanding of the biology of IDH1mut leukemia may further improve the treat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::232d9d6c55023d72b44fa0218107585e
https://doi.org/10.1182/blood-2018-99-110425
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10
Signaling Pathways of Mutant IDH1 Independent of R-2-Hydroxyglutarate
Autor: Nidhi Jyotsana, Anuhar Chaturvedi, Ramya Goparaju, Renate Schottmann, Felicitas Thol, Michael Heuser, Eduard A. Struys, Amit Sharma, Charu Gupta, Michelle Maria Araujo Cruz, Arnold Ganser, Erwin E.W. Jansen, Kerstin Görlich
Publikováno v: Blood. 132:2617-2617
Michael Heuser and Anuhar Chaturvedi share senior authorship Background: Isocitrate dehydrogenase-1 (IDH1) is mutated in about 6% of AML patients. Mutant IDH produces R-2-hydroxyglutarate (R-2HG), which induces histone and DNA hypermethylation throug
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2322cf41af50b00ad6912313a07ae9ec
https://doi.org/10.1182/blood-2018-99-110159
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