Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Renate S, Hagedoorn"'
Autor:
Linda Voogd, Anne M.H.F. Drittij, Calinda K.E. Dingenouts, Kees L.M.C. Franken, Vincent van Unen, Krista E. van Meijgaarden, Paula Ruibal, Renate S. Hagedoorn, Judith A. Leitner, Peter Steinberger, Mirjam H.M. Heemskerk, Mark M. Davis, Thomas J. Scriba, Tom H.M. Ottenhoff, Simone A. Joosten
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109233- (2024)
Summary: HLA-E molecules can present self- and pathogen-derived peptides to both natural killer (NK) cells and T cells. T cells that recognize HLA-E peptides via their T cell receptor (TCR) are termed donor-unrestricted T cells due to restricted alle
Externí odkaz:
https://doaj.org/article/a894387ea1f243a4aa763eb88025c1d8
Autor:
Marije A.J. de Rooij, Dennis F.G. Remst, Dirk M. van der Steen, Anne K. Wouters, Renate S. Hagedoorn, Michel G.D. Kester, Miranda H. Meeuwsen, Tassilo L.A. Wachsmann, Arnoud H. de Ru, Peter A. van Veelen, Els M.E. Verdegaal, J.H. Frederik Falkenburg, Mirjam H.M. Heemskerk
Publikováno v:
Molecular Therapy: Oncolytics, Vol 31, Iss , Pp 100738- (2023)
Externí odkaz:
https://doaj.org/article/7c73b9078d954e7dbfd0dc7bad6960f5
Autor:
Rosa A. van Amerongen, Laura T. Morton, Umesh G. Chaudhari, Dennis F.G. Remst, Renate S. Hagedoorn, Cathelijne W. van den Berg, Christian Freund, J.H. Frederik Falkenburg, Mirjam H.M. Heemskerk
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 28, Iss , Pp 249-261 (2023)
The balance between safety and efficacy of T cell therapies remains challenging and T cell mediated toxicities have occurred. The stringent selection of tumor-specific targets and careful selection of tumor-specific T cells using T cell toxicity scre
Externí odkaz:
https://doaj.org/article/f9a7315aa021462c81fefd32e9e39fe4
Autor:
Miranda H. Meeuwsen, Anne K. Wouters, Tassilo L. A. Wachsmann, Renate S. Hagedoorn, Michel G. D. Kester, Dennis F. G. Remst, Dirk M. van der Steen, Arnoud H. de Ru, Els P. van Hees, Martijn Kremer, Marieke Griffioen, Peter A. van Veelen, J. H. Frederik Falkenburg, Mirjam H. M. Heemskerk
Publikováno v:
Journal of Hematology & Oncology, Vol 16, Iss 1, Pp 1-16 (2023)
Abstract Background The immunoglobulin J chain (Jchain) is highly expressed in the majority of multiple myeloma (MM), and Jchain-derived peptides presented in HLA molecules may be suitable antigens for T-cell therapy of MM. Methods Using immunopeptid
Externí odkaz:
https://doaj.org/article/7ac453320c1d437f953208e7b8991e99
Autor:
Willemijn van der Wulp, Anna M. Gram, Boris Bleijlevens, Renate S. Hagedoorn, Can Araman, Robbert Q. Kim, Jan Wouter Drijfhout, Paul W. H. I. Parren, Richard G. Hibbert, Rob C. Hoeben, Sander I. van Kasteren, Janine Schuurman, Maaike E. Ressing, Mirjam H. M. Heemskerk
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Therapeutic antibody-epitope conjugates (AECs) are promising new modalities to deliver immunogenic epitopes and redirect virus-specific T-cell activity to cancer cells. Nevertheless, many aspects of these antibody conjugates require optimization to i
Externí odkaz:
https://doaj.org/article/458e15a064ab40b08049bc6f97a6578d
Autor:
Rosa A. van Amerongen, Sander Tuit, Anne K. Wouters, Marian van de Meent, Sterre L. Siekman, Miranda H. Meeuwsen, Tassilo L. A. Wachsmann, Dennis F. G. Remst, Renate S. Hagedoorn, Dirk M. van der Steen, Arnoud H. de Ru, Els M. E. Verdegaal, Peter A. van Veelen, J. H. Frederik Falkenburg, Mirjam H. M. Heemskerk
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Recurrent disease emerges in the majority of patients with ovarian cancer (OVCA). Adoptive T-cell therapies with T-cell receptors (TCRs) targeting tumor-associated antigens (TAAs) are considered promising solutions for less-immunogenic ‘cold’ ova
Externí odkaz:
https://doaj.org/article/97169a79cc174ce282d2474ef1bf87ec
Autor:
Tassilo L. A. Wachsmann, Anne K. Wouters, Dennis F. G. Remst, Renate S. Hagedoorn, Miranda H. Meeuwsen, Eline van Diest, Jeanette Leusen, Jürgen Kuball, J. H. Frederik Falkenburg, Mirjam H. M. Heemskerk
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Chimeric antigen receptor (CAR) T cell therapies have resulted in profound clinical responses in the treatment of CD19-positive hematological malignancies, but a significant proportion of patients do not respond or relapse eventually. As an alternati
Externí odkaz:
https://doaj.org/article/61bf7803b46c4bb0b949c96cdcd43b7e
Autor:
Cilia R Pothast, Romy C Dijkland, Melissa Thaler, Renate S Hagedoorn, Michel GD Kester, Anne K Wouters, Pieter S Hiemstra, Martijn J van Hemert, Stephanie Gras, JH Frederik Falkenburg, Mirjam HM Heemskerk
Publikováno v:
eLife, Vol 11 (2022)
Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) specific CD4+ and CD8+ T cells in SARS-CoV-2-unexposed donors has been explained by the presence of T cells primed by other coronaviruses. However, based on the relatively high
Externí odkaz:
https://doaj.org/article/647bdbd851504164827c41c2ee7c4dee
Autor:
Peter A van Veelen, Marieke Griffioen, Arnoud H de Ru, Anne K Wouters, Dennis F G Remst, J H Frederik Falkenburg, Mirjam H M Heemskerk, Rosa A van Amerongen, Renate S Hagedoorn, Danique C Assendelft, Dirk M van der Steen, Marian van de Meent, Michel G D Kester
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 6 (2022)
Externí odkaz:
https://doaj.org/article/a69f5f400b00455f8102fd194246214f
Autor:
Peter van Balen, Inge Jedema, Marleen M. van Loenen, Renate de Boer, H. M. van Egmond, Renate S. Hagedoorn, Conny Hoogstaten, Sabrina A. J. Veld, Lois Hageman, P. A. G. van Liempt, Jaap-Jan Zwaginga, Pauline Meij, H. Veelken, J. H. F. Falkenburg, Mirjam H. M. Heemskerk
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Graft-vs.-leukemia (GVL) reactivity after HLA-matched allogeneic stem cell transplantation (alloSCT) is mainly mediated by donor T cells recognizing minor histocompatibility antigens (MiHA). If MiHA are targeted that are exclusively expressed on hema
Externí odkaz:
https://doaj.org/article/f6e5e712427544debad871b0b6113093