Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Renate Hasenbank"'
Autor:
Eberhard Scherzinger, Claudia Abraham, Stephanie Waelter, Martin Stroedicke, Christian Haenig, Anja Droege, Erich E. Wanker, Renate Hasenbank, Sarah H. Coleman, Anja Fritzsche, Hans Lehrach, Jaana Suopanki, Katrin S. Lindenberg, Ulrich Stelzl, Heike Goehler, Bernhard Landwehrmeyer, Bianca Bauer, Uwe Worm, Maciej Lalowski, Martin Herbst, Andreas H. Ludewig, Maria Knoblich, Claire-Anne Gutekunst, Konrad Buessow
Publikováno v:
Molecular Cell. 15:853-865
Analysis of protein-protein interactions (PPIs) is a valuable approach for characterizing proteins of unknown function. Here, we have developed a strategy combining library and matrix yeast two-hybrid screens to generate a highly connected PPI networ
Autor:
Erich E. Wanker, Renate Hasenbank, Eberhard Scherzinger, Holger Eickhoff, Hans Lehrach, Niels Wedemeyer, Stephanie Wälter, Annie Sittler, Gillian P. Bates
Publikováno v:
Molecular Cell. 2:427-436
The mechanism by which aggregated polyglns cause the selective neurodegeneration in Huntington's disease (HD) is unknown. Here, we show that the SH3GL3 protein, which is preferentially expressed in brain and testis, selectively interacts with the HD
Autor:
Hans Lehrach, Gillian P. Bates, Rudi Lurz, Erich E. Wanker, Eberhard Scherzinger, Renate Hasenbank, Birgit Hollenbach, Stephen W. Davies, Mark Turmaine, Laura Mangiarini
Publikováno v:
Cell. 90:549-558
The mechanism by which an elongated polyglutamine sequence causes neurodegeneration in Huntington's disease (HD) is unknown. In this study, we show that the proteolytic cleavage of a GST-huntingtin fusion protein leads to the formation of insoluble h
Autor:
Francois Franceschi, Evelyn Arndt, Irit Sagi, Shulamith Weinstein, J. Müssig, J. Piefke, Renate Hasenbank, Nina Böddeker, Ute Evers, C. Glotz, Ada Yonath, Christiane Paulke, Miriam Laschever
Publikováno v:
Systematic and Applied Microbiology. 16:697-705
Summary Ribosomal particles from Haloarcula marismortui were crystallized. The best crystals, diffracting to 2.9 A resolution and yielding crystallographic data of reasonable quality were grown from the large ribosomal subunits. Attempts at crystalli
Autor:
Rudi Lurz, Erich E. Wanker, Kirupa Sathasivam, Renate Hasenbank, Stephanie Waelter, Eckhard Nordhoff, Heike Goehler, Gillian P. Bates, Eberhard Scherzinger, Hans Lehrach, Christine Gauss
Publikováno v:
Human molecular genetics. 10(17)
The huntingtin interacting protein (HIP1) is enriched in membrane-containing cell fractions and has been implicated in vesicle trafficking. It is a multidomain protein containing an N-terminal ENTH domain, a central coiled-coil forming region and a C
Autor:
Hans Lehrach, Gillian P. Bates, Katja Schweiger, Renate Hasenbank, Eberhard Scherzinger, Annie Sittler, Rudi Lurz, Erich E. Wanker, Volker Heiser
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 96(8)
Huntington’s disease is a progressive neurodegenerative disorder caused by a polyglutamine [poly(Q)] repeat expansion in the first exon of the huntingtin protein. Previously, we showed that N-terminal huntingtin peptides with poly(Q) tracts in the
Publikováno v:
Genomics. 52(2)
The use of genomic libraries maintained in arrayed format is becoming a more and more popular tool for the analysis of molecular evolution and comparative molecular development. Being able to use already existing reference libraries considerably redu
Autor:
Stephanie Wälter, Erich E. Wanker, Renate Hasenbank, Danilo Tait, Hans Lehrach, Eberhard Scherzinger, John Colicelli, Carlos Rovira
Publikováno v:
Human molecular genetics. 6(3)
We report the discovery of the huntingtin interacting protein I (HIP-I) which binds specifically to the N-terminus of human huntingtin, both in the two-hybrid screen and in in vitro binding experiments. For the interaction in vivo, a protein region d
Publikováno v:
Journal of Molecular Biology. 86:171-174
50 S ribosomal core particles lacking proteins L7 and L12 were treated with monovalent antibody fragments specific for individual 50 S ribosomal proteins. Antibodies to proteins L6, L10 and L18 blocked the rebinding of proteins L7 and L12 and consequ
Autor:
Renate Hasenbank, Georg Stöffler, Erika Ochsner, James W. Bodley, Julian Gordon, Joseph H. Highland
Publikováno v:
Proceedings of the National Academy of Sciences. 71:627-630
We previously showed that treatment of Escherichia coli ribosomes with antibodies specific for proteins L7 and L12 inhibits both EF-G·GDP binding and ribosome-dependent GTP hydrolysis (Highland et al. (1973) Proc. Nat. Acad. Sci. USA 70 , 142-150; a