Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Renata Pavlič"'
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 117069- (2024)
The high mortality rate due to chemoresistance in patients with high-grade ovarian cancer (HGSOC) emphasizes the urgent need to determine optimal treatment strategies for advanced and recurrent cases. Our study investigates the interplay between estr
Externí odkaz:
https://doaj.org/article/484be93b874748ddb908f3e4eb7db980
Publikováno v:
Cancers, Vol 15, Iss 14, p 3661 (2023)
Endometrial cancer (EC) is an increasing health concern, with its growth driven by an angiogenic switch that occurs early in cancer development. Our study used publicly available datasets to examine the expression of angiogenesis-related genes and pr
Externí odkaz:
https://doaj.org/article/6d85ea4c4a2e40be82cbd48398179b9d
Autor:
Jakob Kljun, Renata Pavlič, Eva Hafner, Tanja Lipec, Sara Moreno-Da Silva, Primož Tič, Iztok Turel, Tomaž Büdefeld, Jure Stojan, Tea Lanišnik Rižner
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
In this study, we present the synthesis, kinetic studies of inhibitory activity toward aldo-keto reductase 1C (AKR1C) enzymes, and anticancer potential toward chemoresistant ovarian cancer of 10 organoruthenium compounds bearing diketonate (1–6) an
Externí odkaz:
https://doaj.org/article/f20c38b2a3054eb28ff3e7533d899f2f
Autor:
Renata Pavlič, Marija Gjorgoska, Eva Hafner, Maša Sinreih, Kristina Gajser, Stefan Poschner, Walter Jäger, Tea Lanišnik Rižner
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Endometrial cancer (EC) is the most common gynecological malignancy in resource-abundant countries. The majority of EC cases are estrogen dependent but the mechanisms of estrogen biosynthesis and oxidative metabolism and estrogen action are not compl
Externí odkaz:
https://doaj.org/article/6336b51297f74a35b21700fe0aaeb502
Publikováno v:
Cancers, Vol 14, Iss 11, p 2583 (2022)
Ovarian cancer (OC) is highly lethal and heterogeneous. Several hormones are involved in OC etiology including estrogens; however, their role in OC is not completely understood. Here, we performed targeted transcriptomics and estrogen metabolism anal
Externí odkaz:
https://doaj.org/article/47fd968f64ef481b9bbbf4bb2b4e55be
Autor:
Renata Pavlič, Suzana Vidic, Maja Anko, Tamara Knific, Tomaž Büdefeld, Kristina Marton, Maša Sinreih, Stefan Poschner, Walter Jäger, Snježana Frković-Grazio, Tea Lanišnik Rižner
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8, p 3819 (2021)
Endometrial cancer (EC) is associated with increased estrogen actions. Locally, estrogens can be formed from estrone-sulphate (E1-S) after cellular uptake by organic anion-transporting polypeptides (OATP) or organic anion transporters (OAT). Efflux o
Externí odkaz:
https://doaj.org/article/2a297a4741604ca5a2beb4738fff4867
Autor:
Stefan Poschner, Judith Wackerlig, Dan Cacsire Castillo-Tong, Andrea Wolf, Isabel von der Decken, Tea Lanišnik Rižner, Renata Pavlič, Anastasia Meshcheryakova, Diana Mechtcheriakova, Monika Fritzer-Szekeres, Theresia Thalhammer, Walter Jäger
Publikováno v:
Cancers, Vol 12, Iss 2, p 279 (2020)
High-grade serous ovarian cancer (HGSOC) is currently treated with cytoreductive surgery and platinum-based chemotherapy. The majority of patients show a primary response; however, many rapidly develop drug resistance. Antiestrogens have been studied
Externí odkaz:
https://doaj.org/article/b0ebc81714b84ff2a6eccd95a1bdaa12
Publikováno v:
Ovarian cancer.
Autor:
Stefan Poschner, Walter Jäger, Tea Lanišnik Rižner, Eva Hafner, Kristina Marton, Marija Gjorgoska, Renata Pavlič, Maša Sinreih
Publikováno v:
Endometrial cancer.
Introduction/Background* Endometrial cancer (EC) is the most common gynecological malignancy in the western world. EC has traditionally been divided into type I, which is estrogen dependent, and type II, where associations with estrogens were only re
Publikováno v:
Miscellaneous.
Introduction/Background* Endometrial (EC) and ovarian cancer (OC) are female pathologies that express androgen receptor (AR) to different extents, however, the role of the AR ligands, i.e., androgens and their 11-oxygenated metabolites in EC and OC o