Phagocytosis of Leptospira by leukocytes from mice with different susceptibility to leptospirosis and possible role of chemokines

Autor: Paloma L. da Silva, Fabiana Lauretti-Ferreira, Maiara Caldas de Lima, Swiany Silveira Lima, Ambart E. Covarrubias, Marcelo De Franco, Eneas Carvalho, Paulo Lee Ho, Renata M. A. da Costa, Elizabeth A. L. Martins, Josefa B. Da Silva

Publikováno v: BMC Microbiology, Vol 19, Iss 1, Pp 1-10 (2019)

Abstract Background Leptospirosis is a widespread zoonosis caused by pathogenic prokaryotic microbes of the genus Leptospira. Although there are several reports in the literature, host-pathogen interaction is still poorly understood. The role of chem

Externí odkaz: https://doaj.org/article/85e00460930043aea05ec440f7c93ba7

Flomoxef and fosfomycin in combination for the treatment of neonatal sepsis in the setting of highly prevalent antimicrobial resistance

Autor: Christopher A. Darlow, Nicola Farrington, Adam Johnson, Laura McEntee, Jennifer Unsworth, Ana Jimenez-Valverde, Ruwanthi Kolamunnage-Dona, Renata M A Da Costa, Sally Ellis, François Franceschi, Mike Sharland, Michael Neely, Laura J. V. Piddock, Shampa Das, William Hope

Publikováno v: Journal of Antimicrobial Chemotherapy. 77:1334-1343

Background Neonatal sepsis is a serious bacterial infection of neonates, globally killing up to 680 000 babies annually. It is frequently complicated by antimicrobial resistance, particularly in low- and middle-income country (LMIC) settings with wid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3934ff099d0f6545b7a9d3e29d98695
https://doi.org/10.1093/jac/dkac038

A Three-Dimensional Lung Cell Model to Leptospira Virulence Investigations

Autor: Camila L. Campos, Luciana R. Gomes, Ambart E. Covarrubias, Ellen E. Kato, Gisele G. Souza, Silvio A. Vasconcellos, Marcos B. Heinemann, Elizabeth A. L. Martins, Paulo L. Ho, Renata M. A. Da Costa, Josefa B. Da Silva

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29dcde183fe5c003a6075254b1d52e58
https://doi.org/10.1007/s00284-021-02720-5

A Three-Dimensional Lung Cell Model to Leptospira Virulence Investigations

Autor: Camila L, Campos, Luciana R, Gomes, Ambart E, Covarrubias, Ellen E, Kato, Gisele G, Souza, Silvio A, Vasconcellos, Marcos B, Heinemann, Elizabeth A L, Martins, Paulo L, Ho, Renata M A, Da Costa, Josefa B, Da Silva

Publikováno v: Current microbiology. 79(2)

Leptospirosis is a worldwide zoonosis and a serious public health threat in tropical and subtropical areas. The etiologic agents of leptospirosis are pathogenic spirochetes from the genus Leptospira. In severe cases, patients develop a pulmonary hemo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a97a1c34b0549cea041311ff9c626e9d
https://pubmed.ncbi.nlm.nih.gov/34982247

Analysis of LexA binding sites and transcriptomics in response to genotoxic stress inLeptospira interrogans

Autor: Janet L. Smith, Josefa B. da Silva, Renata M. A. da Costa, Juliana S Milanez, Renan H. Domingos, Alan D. Grossman, Helder I. Nakaya, Paulo Lee Ho, Luciane Schons-Fonseca

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Oxford University Press
Nucleic Acids Research

We determined the effects of DNA damage caused by ultraviolet radiation on gene expression in Leptospira interrogans using DNA microarrays. These data were integrated with DNA binding in vivo of LexA1, a regulator of the DNA damage response, assessed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5371b9522cd3314d15b8beecedb3e989
https://doi.org/10.1093/nar/gkv1536