Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Renata M., Oballa"'
Autor:
Ian Paterson, David Y.‐K. Chen, Mark J. Coster, Jose L. Aceña, Jordi Bach, Karl R. Gibson, Linda E. Keown, Renata M. Oballa, Thomas Trieselmann, Debra J. Wallace, Andrew P. Hodgson, Roger D. Norcross
Publikováno v:
Angewandte Chemie. 113:4179-4184
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1f6e4eea8c1640679bf4d238cf7dae8
https://doi.org/10.1002/1521-3757(20011105)113:21<4179::aid-ange4179>3.0.co
https://doi.org/10.1002/1521-3757(20011105)113:21<4179::aid-ange4179>3.0.co
Publikováno v:
Tetrahedron Letters. 39:8545-8548
The C1C28 aldehyde 5, containing the AB- and CD-spiroacetal portions together with the bridging chain of spongistatin 1 (1), was prepared. The key step was a lithium-mediated, anti-aldol coupling between ethyl ketone 4 and aldehyde 6 under Felkin-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75ccc1a03f8880b76c342f7626740b3e
https://doi.org/10.1016/s0040-4039(98)01908-x
https://doi.org/10.1016/s0040-4039(98)01908-x
Autor:
Ian Paterson, Renata M. Oballa
Publikováno v:
Tetrahedron Letters. 38:8241-8244
The C1C15 aldehyde 3, containing the AB-spiroacetal of spongistatin 1 (1), was prepared in 17 steps from methyl ketone (S)-8. The C15 and C16 stereocentres could be introduced together, relying on Felkin-Anh control, by using a boron-mediated, ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5b0ac77500a5051ffe7522d7a657c13
https://doi.org/10.1016/s0040-4039(97)10126-5
https://doi.org/10.1016/s0040-4039(97)10126-5
Publikováno v:
Tetrahedron Letters. 37:8585-8588
High levels of 1,5-stereoinduction are obtained in the boron-mediated aldol reactions of β-oxygenated methyl ketones 5,7 and 8 with achiral aldehydes. The aldol products undergo stereoselective reductions, providing an efficient method of accessing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3496bee1e4f562cb627c81c64a3b3ba
https://doi.org/10.1016/0040-4039(96)01962-4
https://doi.org/10.1016/0040-4039(96)01962-4
Publikováno v:
Tetrahedron Letters. 37:8581-8584
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd42b86a31bbc1c2683a4a84872bad28
https://doi.org/10.1016/0040-4039(96)01961-2
https://doi.org/10.1016/0040-4039(96)01961-2
Autor:
Renata M. Oballa, Liette Belair, W. Cameron Black, Kelly Bleasby, Chi Chung Chan, Carole Desroches, Xiaobing Du, Robert Gordon, Jocelyne Guay, Sebastien Guiral, Michael J. Hafey, Emelie Hamelin, Zheng Huang, Brian Kennedy, Nicolas Lachance, France Landry, Chun Sing Li, Joseph Mancini, Denis Normandin, Alessandro Pocai, David A. Powell, Yeeman K. Ramtohul, Kathryn Skorey, Dan Sørensen, Wayne Sturkenboom, Angela Styhler, Deena M. Waddleton, Hao Wang, Simon Wong, Lijing Xu, Lei Zhang
Publikováno v:
Journal of medicinal chemistry. 54(14)
The potential use of SCD inhibitors for the chronic treatment of diabetes and dyslipidemia has been limited by preclinical adverse events associated with inhibition of SCD in skin and eye tissues. To establish a therapeutic window, we embarked on des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1c43863779b7e91be0da9e7afe20903
https://pubmed.ncbi.nlm.nih.gov/21661758
https://pubmed.ncbi.nlm.nih.gov/21661758
Publikováno v:
Canadian Journal of Chemistry. 71:1484-1494
A total synthesis of the structurally novel, antimicrobial diterpenoid (±)-8,15-diisocyano-11(20)-amphilectene (2) is described. Alkylation of 2-methoxycarbonyl-3-methylcyclohexanone (13) with (E)-1-(tert-butyldimethylsiloxy)-6-iodo-3-(trimethylstan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd65f637dbfa1843e4b059d75510622a
https://doi.org/10.1139/v93-189
https://doi.org/10.1139/v93-189
Publikováno v:
ChemInform. 25
A total synthesis of the structurally novel, antimicrobial diterpenoid (±)-8,15-diisocyano-11(20)-amphilectene (2) is described. Alkylation of 2-methoxycarbonyl-3-methylcyclohexanone (13) with (E)-...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::620962c5e680c4d5b40314519153e0cd
https://doi.org/10.1002/chin.199409232
https://doi.org/10.1002/chin.199409232
Autor:
Edward Piers, Renata M. Oballa
Publikováno v:
ChemInform. 26
Conjugate addition of the organocuprate reagent 3 to the enones 10–13, followed by germanium-iodine exchange of the resultant products, provides the bicyclic vinyl iodides 18a–21a, 18b, 20b, and 21b. Palladium(0)-catalyzed cyclization of the latt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe2456608845ed2ba96dac061389254b
https://doi.org/10.1002/chin.199548114
https://doi.org/10.1002/chin.199548114
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5cf6c1442c20c333529fb09dc3bcd22
https://doi.org/10.1002/chin.199712225
https://doi.org/10.1002/chin.199712225