Leptospira interrogans serovar copenhageni harbors two lexA genes involved in SOS response.

Autor: Luciane S Fonseca, Josefa B da Silva, Juliana S Milanez, Claudia B Monteiro-Vitorello, Leonardo Momo, Zenaide M de Morais, Silvio A Vasconcellos, Marilis V Marques, Paulo L Ho, Renata M A da Costa

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e76419 (2013)

Bacteria activate a regulatory network in response to the challenges imposed by DNA damage to genetic material, known as the SOS response. This system is regulated by the RecA recombinase and by the transcriptional repressor lexA. Leptospira interrog

Externí odkaz: https://doaj.org/article/187467e0f2bc4bbf8bb07c75fdad2fd8

Flomoxef and fosfomycin in combination for the treatment of neonatal sepsis in the setting of highly prevalent antimicrobial resistance

Autor: Christopher A. Darlow, Nicola Farrington, Adam Johnson, Laura McEntee, Jennifer Unsworth, Ana Jimenez-Valverde, Ruwanthi Kolamunnage-Dona, Renata M A Da Costa, Sally Ellis, François Franceschi, Mike Sharland, Michael Neely, Laura J. V. Piddock, Shampa Das, William Hope

Publikováno v: Journal of Antimicrobial Chemotherapy. 77:1334-1343

Background Neonatal sepsis is a serious bacterial infection of neonates, globally killing up to 680 000 babies annually. It is frequently complicated by antimicrobial resistance, particularly in low- and middle-income country (LMIC) settings with wid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3934ff099d0f6545b7a9d3e29d98695
https://doi.org/10.1093/jac/dkac038

A Three-Dimensional Lung Cell Model to Leptospira Virulence Investigations

Autor: Camila L. Campos, Luciana R. Gomes, Ambart E. Covarrubias, Ellen E. Kato, Gisele G. Souza, Silvio A. Vasconcellos, Marcos B. Heinemann, Elizabeth A. L. Martins, Paulo L. Ho, Renata M. A. Da Costa, Josefa B. Da Silva

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29dcde183fe5c003a6075254b1d52e58
https://doi.org/10.1007/s00284-021-02720-5

A Three-Dimensional Lung Cell Model to Leptospira Virulence Investigations

Autor: Camila L, Campos, Luciana R, Gomes, Ambart E, Covarrubias, Ellen E, Kato, Gisele G, Souza, Silvio A, Vasconcellos, Marcos B, Heinemann, Elizabeth A L, Martins, Paulo L, Ho, Renata M A, Da Costa, Josefa B, Da Silva

Publikováno v: Current microbiology. 79(2)

Leptospirosis is a worldwide zoonosis and a serious public health threat in tropical and subtropical areas. The etiologic agents of leptospirosis are pathogenic spirochetes from the genus Leptospira. In severe cases, patients develop a pulmonary hemo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a97a1c34b0549cea041311ff9c626e9d
https://pubmed.ncbi.nlm.nih.gov/34982247

Analysis of LexA binding sites and transcriptomics in response to genotoxic stress inLeptospira interrogans

Autor: Janet L. Smith, Josefa B. da Silva, Renata M. A. da Costa, Juliana S Milanez, Renan H. Domingos, Alan D. Grossman, Helder I. Nakaya, Paulo Lee Ho, Luciane Schons-Fonseca

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Oxford University Press
Nucleic Acids Research

We determined the effects of DNA damage caused by ultraviolet radiation on gene expression in Leptospira interrogans using DNA microarrays. These data were integrated with DNA binding in vivo of LexA1, a regulator of the DNA damage response, assessed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5371b9522cd3314d15b8beecedb3e989
https://doi.org/10.1093/nar/gkv1536