Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Renata L.S. Goncalves"'
Publikováno v:
Redox Biology, Vol 28, Iss , Pp - (2020)
Reactive oxygen species are important signaling molecules crucial for muscle differentiation and adaptation to exercise. However, their uncontrolled generation is associated with an array of pathological conditions. To identify and quantify the sourc
Externí odkaz:
https://doaj.org/article/f447c6fecc6e4b3a962720926571763c
Autor:
Courtney M. Anderson, Melissa Kazantzis, Jinshan Wang, Subramaniam Venkatraman, Renata L.S. Goncalves, Casey L. Quinlan, Ryan Ng, Martin Jastroch, Daniel I. Benjamin, Biao Nie, Candice Herber, An-Angela Ngoc Van, Michael J. Park, Dawee Yun, Karen Chan, Angela Yu, Peter Vuong, Maria Febbraio, Daniel K. Nomura, Joseph L. Napoli, Martin D. Brand, Andreas Stahl
Publikováno v:
Cell Reports, Vol 10, Iss 4, Pp 505-515 (2015)
Brown adipose tissue (BAT) possesses the inherent ability to dissipate metabolic energy as heat through uncoupled mitochondrial respiration. An essential component of the mitochondrial electron transport chain is coenzyme Q (CoQ). While cells synthes
Externí odkaz:
https://doaj.org/article/03dde8870bad423885f791131ed3e58b
Autor:
Renata L.S. Goncalves, Daniel E. Rothschild, Casey L. Quinlan, Gary K. Scott, Christopher C. Benz, Martin D. Brand
Publikováno v:
Redox Biology, Vol 2, Iss C, Pp 901-909 (2014)
p53 Inducible gene 6 (PIG6) encodes mitochondrial proline dehydrogenase (PRODH) and is up-regulated several fold upon p53 activation. Proline dehydrogenase is proposed to generate radicals that contribute to cancer cell apoptosis. However, there are
Externí odkaz:
https://doaj.org/article/19da9bd8d6454addab9675cf8d357e39
Autor:
Renata L.S. Goncalves, Zeqiu Branden Wang, Karen E. Inouye, Grace Yankun Lee, Xiaorong Fu, Jani Saksi, Clement Rosique, Gunes Parlakgul, Ana Paula Arruda, Sheng Tony Hui, Mar Coll Loperena, Shawn C. Burgess, Isabel Graupera, Gökhan S. Hotamisligil
Publikováno v:
bioRxiv
Mitochondrial reactive oxygen species (mROS) are central to physiology. While excess mROS production has been associated with several disease states, its precise sources, regulation, and mechanism of generationin vivoremain unknown, limiting translat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b30c4a300c0787e77c86b802a90f13ab
https://doi.org/10.1101/2023.02.21.528863
https://doi.org/10.1101/2023.02.21.528863
Autor:
Alexander Bartelt, Gökhan S. Hotamisligil, Martin D. Brand, Michael Schlame, Renata L.S. Goncalves
Publikováno v:
Febs Letters
Barth syndrome (BTHS) is a rare X-linked genetic disorder caused by mutations in the gene encoding the transacylase tafazzin and characterized by loss of cardiolipin and severe cardiomyopathy. Mitochondrial oxidants have been implicated in the cardio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c3b8df4ffe6a7d0e501f719634e5e6c
http://europepmc.org/articles/PMC7894513
http://europepmc.org/articles/PMC7894513
Publikováno v:
Cell Metabolism. 30:999-1001
Cells utilize multiple mechanisms to support endoplasmic reticulum (ER) function. The unfolded protein response, UPRER, is engaged during proteotoxic challenges to either mitigate ER stress or promote apoptosis. In a CRISPR-based genetic screen, Schi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c7c38301b7f5336b66e7e9223984abf
https://doi.org/10.1016/j.cmet.2019.11.008
https://doi.org/10.1016/j.cmet.2019.11.008
Autor:
Carlos Frederico Leite Fontes, Julio A. Mignaco, Marcos A. Vannier-Santos, Marcus F. Oliveira, Luciana E S F Machado, A. Gaviraghi, Rafael D. Mesquita, Renata L.S. Goncalves
Publikováno v:
Cells, Vol 10, Iss 470, p 470 (2021)
Cells
Cells
Flight dispersal represents a key aspect of the evolutionary and ecological success of insects, allowing escape from predators, mating, and colonization of new niches. The huge energy demand posed by flight activity is essentially met by oxidative ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8efa2faeb93f1260016a469dada02deb
https://www.mdpi.com/2073-4409/10/2/470
https://www.mdpi.com/2073-4409/10/2/470
Autor:
Martin D. Brand, Michael Schlame, Alexander Bartelt, Gökhan S. Hotamisligil, Renata L.S. Goncalves
Barth Syndrome (BTHS) is a rare X-linked genetic disorder caused by mutations in tafazzin and characterized by loss of cardiolipin and severe cardiomyopathy. Mitochondrial superoxide/H2O2production has been implicated in the cardiomyopathy observed i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af0cb50ec0f732c52f06b4463747d59e
https://doi.org/10.1101/2020.05.07.083105
https://doi.org/10.1101/2020.05.07.083105
Autor:
Matthew D. Lynes, Renata L.S. Goncalves, Gökhan S. Hotamisligil, Daniel Franke, Kosei Eguchi, Gunes Parlakgul, Kornelia Johann, Moungi G. Bawendi, Yu-Hua Tseng, Ana Paula Arruda, Christian Schlein, Luiz O. Leiria, Truc B. Nguyen, Alexander W. Fischer, Karen Inouye, Scott B. Widenmaier, Alexander Bartelt, Nicole A. Snyder, Oliver T. Bruns
Publikováno v:
Nature medicine
Adipocytes possess remarkable adaptive capacity to respond to nutrient excess, fasting or cold exposure, and they are thus an important cell type for the maintenance of proper metabolic health. Although the endoplasmic reticulum (ER) is a critical or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09fe6914a7ec888717d1c9b6218bc1ac
https://doi.org/10.1038/nm.4481
https://doi.org/10.1038/nm.4481
Autor:
Edward K. Ainscow, Carolina N. Turk, Leonardo Vargas, Simon Melov, Heinrich Jasper, Yves T. Wang, Renata L.S. Goncalves, Adam L. Orr, Akos A. Gerencser, H. Michael Petrassi, Irina V. Perevoshchikova, Martin D. Brand, Martin Borch Jensen, Jason T. Matzen, Paul S. Brookes, Shelly Meeusen, Victoria J. Dardov
Publikováno v:
Cell Metabolism. 24:582-592
Summary Using high-throughput screening we identified small molecules that suppress superoxide and/or H 2 O 2 production during reverse electron transport through mitochondrial respiratory complex I (site I Q ) without affecting oxidative phosphoryla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d49d72d399c488b4609372faf454577
https://doi.org/10.1016/j.cmet.2016.08.012
https://doi.org/10.1016/j.cmet.2016.08.012