Výsledky vyhledávání - "Renata Koževnikovová"

Akademický článek

Genotype and Haplotype Analyses of TP53 Gene in Breast Cancer Patients: Association with Risk and Clinical Outcomes.

Autor: Veronika Vymetalkova, Pavel Soucek, Tereza Kunicka, Katerina Jiraskova, Veronika Brynychova, Barbara Pardini, Vendula Novosadova, Zdena Polivkova, Katerina Kubackova, Renata Kozevnikovova, Miloslav Ambrus, Ludmila Vodickova, Alessio Naccarati, Pavel Vodicka

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0134463 (2015)

Variations in the TP53 gene have been suggested to play a role in many cancers, including breast. We previously observed an association between TP53 haplotypes based on four polymorphisms (rs17878362, rs1042522, rs12947788, and rs17884306) and the ri

Externí odkaz: https://doaj.org/article/daa9818343444ee98abf92c5511e42d0

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Akademický článek

Integrative analysis of mRNA and miRNA expression profiles and somatic variants in oxysterol signaling in early‐stage luminal breast cancer

Autor: Petr Holý, Veronika Brynychová, Karolína Šeborová, Vojtěch Haničinec, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Pavel Souček

Publikováno v: Molecular Oncology, Vol 17, Iss 10, Pp 2074-2089 (2023)

Oxysterols, oxidized derivatives of cholesterol, act in breast cancer (BC) as selective estrogen receptor modulators and affect cholesterol homeostasis, drug transport, nuclear and cell receptors, and other signaling proteins. Using data from three h

Externí odkaz: https://doaj.org/article/dc346fd6f49f495581f9e427e684f5cc

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Single Nucleotide Variants in KIF14 Gene May Have Prognostic Value in Breast Cancer

Autor: Ivona Krus, Veronika Brynychová, Viktor Hlaváč, Radka Václavíková, Maria Kováčová, Renata Koževnikovová, Katerina Kopečková, Jannis Tornikidis, David Vrána, Jiří Gatěk, Pavel Souček

Publikováno v: Molecular Diagnosis & Therapy. 26:665-678

Human kinesin 14 (KIF14) is one of the 70 prognostic marker genes (so-called Amsterdam profile) previously identified by the microarray of breast carcinomas, and its high transcript expression in tumor specimens indicates a poor prognosis for patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89d7166c07298196142d27a3ba6187fb
https://doi.org/10.1007/s40291-022-00616-z

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Germline and somatic genetic variability of oxysterol-related genes in breast cancer patients with early disease of the luminal subtype

Autor: Petr Holý, Viktor Hlaváč, Pavel Ostašov, Veronika Brynychová, Renata Koževnikovová, Markéta Trnková, Kateřina Kopečková, Soňa Měšťáková, Marcela Mrhalová, Pavel Souček

Publikováno v: Biochimie. 199

Oxysterols, oxidized derivatives of cholesterol, have been implicated in multiple pathologies, including cancer. In breast cancer, the link is especially strong due to interactions between oxysterols and estrogen receptor activity. Here, we provide t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b09f59f5a9172d30578a3937019d034
https://pubmed.ncbi.nlm.nih.gov/35525372

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Role of genetic variation in cytochromes P450 in breast cancer prognosis and therapy response

Autor: Pavel Soucek, Viktor Hlavac, Katerina Kopeckova, Pavel Ostasov, Radka Vaclavikova, Jiří Gatěk, Renata Koževnikovová, Veronika Brynychova, David Vrána

Publikováno v: International journal of molecular sciences
International Journal of Molecular Sciences
Volume 22
Issue 6
International Journal of Molecular Sciences, Vol 22, Iss 2826, p 2826 (2021)

Breast cancer is the most frequent cancer in the female population worldwide. The role of germline genetic variability in cytochromes P450 (CYP) in breast cancer prognosis and individualized therapy awaits detailed elucidation. In the present study,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c07b7ea89be65dd1ce98291e56c40ee7
http://publikace.k.utb.cz/handle/10563/1010294

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Role of Genetic Variation in ABC Transporters in Breast Cancer Prognosis and Therapy Response

Autor: Katerina Kopeckova, Pavel Soucek, Radka Vaclavikova, David Vrána, Renata Koževnikovová, Viktor Hlavac, Jiří Gatěk, Veronika Brynychova

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 9556, p 9556 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 24

Breast cancer is the most common cancer in women in the world. The role of germline genetic variability in ATP-binding cassette (ABC) transporters in cancer chemoresistance and prognosis still needs to be elucidated. We used next-generation sequencin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::551eb947af7f46a38ea63ad2727b2762
https://www.mdpi.com/1422-0067/21/24/9556

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The expression profile of ATP-binding cassette transporter genes in breast carcinoma

Autor: Marie Ehrlichová, Marketa Trnkova, Renata Koževnikovová, Viktor Hlavac, Jiří Gatěk, Radka Vaclavikova, Dana Kopperová, Ivan Gut, Vaclav Pecha, David Vrána, Veronika Brynychova, Pavel Soucek

Publikováno v: Pharmacogenomics. 14(5)

Aim: ATP-binding cassette (ABC) transporters contribute to development of resistance to anticancer drugs via ATP-dependent drug efflux. A major goal of our study was to investigate associations between the expression of ABC transporters and outcome o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435dd73dd93a0890a2c2142597ced58b
https://pubmed.ncbi.nlm.nih.gov/23556449

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