Antileishmanial compounds from Connarus suberosus: Metabolomics, isolation and mechanism of action.

Autor: Lais S Morais, Renata G Dusi, Daniel P Demarque, Raquel L Silva, Lorena C Albernaz, Sônia N Báo, Christian Merten, Luciana M R Antinarelli, Elaine S Coimbra, Laila S Espindola

Publikováno v: PLoS ONE, Vol 15, Iss 11, p e0241855 (2020)

Leishmaniasis is a disease impacting public health worldwide due to its high incidence, morbidity and mortality. Available treatments are costly, lengthy and toxic, not to mention the problem of parasite resistance. The development of alternative tre

Externí odkaz: https://doaj.org/article/f8248aafa4a74176a3eb4767ecc9f7cb

Cytotoxic Triterpenes from Salacia crassifolia and Metabolite Profiling of Celastraceae Species

Autor: Laila S. Espindola, Renata G. Dusi, Daniel P. Demarque, Raimundo Braz-Filho, Pengcheng Yan, Heidi R. Bokesch, Kirk R. Gustafson, John A. Beutler

Publikováno v: Molecules, Vol 23, Iss 6, p 1494 (2018)

The new pentacyclic triterpene 11β-hydroxypristimerin (1), along with the known metabolites pristimerin (2), 6-oxopristimerol (3) and vitideasin (4), were isolated from a Salacia crassifolia root wood extract, following a bioassay-guided fractionati

Externí odkaz: https://doaj.org/article/1868e97c0ea44326b196157e58c377d5

Residual Larvicidal Activity of Quinones against Aedes aegypti

Autor: João Paulo Barreto Sousa, Renata G. Dusi, Daniel P. Demarque, Lorena C Albernaz, Raquel L. Silva, Laila S. Espindola

Publikováno v: Molecules, Vol 25, Iss 3978, p 3978 (2020)
Molecules
Volume 25
Issue 17

The number of documented dengue cases has increased dramatically in recent years due to transmission through the Aedes aegypti mosquito bite. Vector control remains the most effective measure to protect against this and other arboviral diseases inclu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33345f3fa3c59a94adf49a063d89ad70
https://www.mdpi.com/1420-3049/25/17/3978

Antileishmanial compounds from Connarus suberosus: Metabolomics, isolation and mechanism of action

Autor: Luciana M.R. Antinarelli, Elaine Soares Coimbra, Raquel L. Silva, Daniel P. Demarque, Christian Merten, Sônia Nair Báo, Lais S. Morais, Laila S. Espindola, Renata G. Dusi, Lorena C Albernaz

Publikováno v: PLoS ONE, Vol 15, Iss 11, p e0241855 (2020)
PLoS ONE

Leishmaniasis is a disease impacting public health worldwide due to its high incidence, morbidity and mortality. Available treatments are costly, lengthy and toxic, not to mention the problem of parasite resistance. The development of alternative tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5b7af7c6add54b0883bf2feb1acce0
https://doaj.org/article/f8248aafa4a74176a3eb4767ecc9f7cb

A Molecular Networking Strategy: High-Throughput Screening and Chemical Analysis of Brazilian Cerrado Plant Extracts against Cancer Cells

Autor: Daniel P. Demarque, Renata G. Dusi, Ekaterina I. Goncharova, John A. Beutler, Lorena C Albernaz, Laila S. Espindola, Patrícia C Cortelo, Kirk R. Gustafson, Raimundo Braz-Filho, Heidi R. Bokesch

Publikováno v: Cells
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Volume 10
Issue 3
Cells, Vol 10, Iss 691, p 691 (2021)

Plants have historically been a rich source of successful anticancer drugs and chemotherapeutic agents, with research indicating that this trend will continue. In this contribution, we performed high-throughput cytotoxicity screening of 702 extracts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff70d32a633b30643a490d3316daa4e6
https://doi.org/10.3390/cells10030691