In vitro-in vivo availability of metformin hydrochloride-PLGA nanoparticles in diabetic rats in a periodontal disease experimental model

Autor: Aline de Sousa Barbosa Freitas Pereira, Maria Laura de Souza Lima, Arnobio Antonio da Silva-Junior, Emanuell dos Santos Silva, Raimundo Fernandes de Araújo Júnior, Agnes Andrade Martins, Jovelina Samara Ferreira Alves, Artur de Santana Oliveira, Leandro De Santis Ferreira, Emily Cintia Tossi de Araújo Costa, Gerlane Coelho Bernardo Guerra, Caroline Addison Carvalho Xavier de Medeiros, Gerly A. C. Brito, Renata Ferreira de Carvalho Leitao, Aurigena Antunes de Araújo

Publikováno v: Pharmaceutical Biology, Vol 59, Iss 1, Pp 1576-1584 (2021)

Context Metformin is an important oral anti-hyperglycemic used in diabetes. Polylactic-co-glycolic acid (PLGA) has been widely used due to its reliability in controlling the release of drugs. Objective This study evaluates the in vitro-in vivo availa

Externí odkaz: https://doaj.org/article/7d4d72e176694e5aa3a792b23b8a3c96

In vitro-in vivo availability of metformin hydrochloride-PLGA nanoparticles in diabetic rats in a periodontal disease experimental model.

Autor: Pereira, Aline de Sousa Barbosa Freitas¹ (AUTHOR), de Souza Lima, Maria Laura¹ (AUTHOR), da Silva-Junior, Arnobio Antonio² (AUTHOR), dos Santos Silva, Emanuell² (AUTHOR), de Araújo Júnior, Raimundo Fernandes³ (AUTHOR), Martins, Agnes Andrade⁴ (AUTHOR), Alves, Jovelina Samara Ferreira⁵ (AUTHOR), Oliveira, Artur de Santana⁵ (AUTHOR), De Santis Ferreira, Leandro⁵ (AUTHOR), de Araújo Costa, Emily Cintia Tossi⁶ (AUTHOR), Guerra, Gerlane Coelho Bernardo⁷ (AUTHOR), de Medeiros, Caroline Addison Carvalho Xavier⁸ (AUTHOR), Brito, Gerly A. C.⁹ (AUTHOR), de Carvalho Leitao, Renata Ferreira¹⁰ (AUTHOR), de Araújo, Aurigena Antunes¹¹ (AUTHOR)

Publikováno v: Pharmaceutical Biology. Dec2021, Vol. 59 Issue 1, p1574-1582. 9p.