44Sc for labeling of DOTA- and NODAGA-functionalized peptides: preclinical in vitro and in vivo investigations

Autor: Katharina A. Domnanich, Cristina Müller, Renata Farkas, Raffaella M. Schmid, Bernard Ponsard, Roger Schibli, Andreas Türler, Nicholas P. van der Meulen

Publikováno v: EJNMMI Radiopharmacy and Chemistry, Vol 1, Iss 1, Pp 1-19 (2016)

Abstract Background Recently, 44Sc (T1/2 = 3.97 h, Eβ+ av = 632 keV, I = 94.3 %) has emerged as an attractive radiometal candidate for PET imaging using DOTA-functionalized biomolecules. The aim of this study was to investigate the potential of usin

Externí odkaz: https://doaj.org/article/426a2a03dc4a46d2ad31181509126f76

Synthesis of New 2-(2´-Hydroxyaryl)benzotriazoles and Evaluation of Their Photochemical Behavior as Potential UV-Filters

Autor: Lajos Novak, Oscar Jiménez, Miguel A. Miranda, Carles Trullas, Olga Gorchs, Mercedesz Törincsi, Jordi Corbera, Virginie Lhiaubet-Vallet, Renata Farkas

Publikováno v: Molecules, Vol 15, Iss 9, Pp 6205-6216 (2010)

Two new 2-(2´-hydroxyaryl)benzotriazole derivatives were synthesized and studied by photophysical and photochemical techniques in order to assess their ability to act as UV-filters. The absorption and emission properties of both compounds were deter

Externí odkaz: https://doaj.org/article/1c93e951b2794891b1a3fc9aa09b10cf

New

Autor: Lauren L, Radford, Solana, Fernandez, Rebecca, Beacham, Retta, El Sayed, Renata, Farkas, Martina, Benešová, Cristina, Müller, Suzanne E, Lapi

Publikováno v: Pharmaceuticals

Overexpression of folate receptors (FRs) on different tumor types (e.g., ovarian, lung) make FRs attractive in vivo targets for directed diagnostic/therapeutic agents. Currently, no diagnostic agent suitable for positron emission tomography (PET) has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::22533c441bb04ff5a19684d34ebcb781
https://pubmed.ncbi.nlm.nih.gov/31717279

64Cu- and 68Ga-Based PET Imaging of Folate Receptor-Positive Tumors: Development and Evaluation of an Albumin-Binding NODAGA–Folate

Autor: Cristina Müller, Simon M. Ametamey, Klaudia Siwowska, Roger Schibli, Renata Farkas, Nicholas P. van der Meulen

Publikováno v: Molecular Pharmaceutics. 13:1979-1987

A number of folate-based radioconjugates have been synthesized and evaluated for nuclear imaging purposes of folate receptor (FR)-positive tumors and potential therapeutic application. A common shortcoming of radiofolates is, however, a significant a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635b8978c7e0a7742c813734f971b772
https://doi.org/10.1021/acs.molpharmaceut.6b00143

44Sc for labeling of DOTA- and NODAGA-functionalized peptides: preclinical in vitro and in vivo investigations

Autor: Katharina Anna Domnanich, Nicholas P. van der Meulen, Cristina Müller, Bernard Ponsard, Renata Farkas, Raffaella M. Schmid, Andreas Türler, Roger Schibli

Publikováno v: Domnanich, Katharina Anna; Müller, Cristina; Farkas, Renata; Schmid, Raffaella M.; Ponsard, Bernard; Schibli, Roger; Türler, Andreas; van der Meulen, Nicholas P. (2016). 44Sc for labeling of DOTA-and NODAGA-functionalized peptides: preclinical in vitro and in vivo investigations. EJNMMI Radiopharmacy and Chemistry, 1(1), p. 8. Springer 10.1186/s41181-016-0013-5
EJNMMI Radiopharmacy and Chemistry, Vol 1, Iss 1, Pp 1-19 (2016)
Ejnmmi Radiopharmacy and Chemistry

Background Recently, 44Sc (T1/2 = 3.97 h, Eβ+ av = 632 keV, I = 94.3 %) has emerged as an attractive radiometal candidate for PET imaging using DOTA-functionalized biomolecules. The aim of this study was to investigate the potential of using NODAGA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f44e6afce732d278b4ca4e0d12b16f01
https://boris.unibe.ch/93779/1/art%3A10.1186%2Fs41181-016-0013-5.pdf