Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Renata B Filler"'
Autor:
Jin Wei, Mia Madel Alfajaro, Wesley L Cai, Vincent R Graziano, Madison S Strine, Renata B Filler, Scott B Biering, Sylvia A Sarnik, Sonam Patel, Bridget L Menasche, Susan R Compton, Silvana Konermann, Patrick D Hsu, Robert C Orchard, Qin Yan, Craig B Wilen
Publikováno v:
PLoS Pathogens, Vol 19, Iss 7, p e1011351 (2023)
Identification of host determinants of coronavirus infection informs mechanisms of pathogenesis and may provide novel therapeutic targets. Here, we demonstrate that the histone demethylase KDM6A promotes infection of diverse coronaviruses, including
Externí odkaz:
https://doaj.org/article/96107a75fb7e477fb76c01fbddef0ecf
DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner.
Autor:
Madison S Strine, Wesley L Cai, Jin Wei, Mia Madel Alfajaro, Renata B Filler, Scott B Biering, Sylvia Sarnik, Ryan D Chow, Ajinkya Patil, Kasey S Cervantes, Clayton K Collings, Peter C DeWeirdt, Ruth E Hanna, Kevin Schofield, Christopher Hulme, Silvana Konermann, John G Doench, Patrick D Hsu, Cigall Kadoch, Qin Yan, Craig B Wilen
Publikováno v:
PLoS Biology, Vol 21, Iss 6, p e3002097 (2023)
Identifying host genes essential for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has the potential to reveal novel drug targets and further our understanding of Coronavirus Disease 2019 (COVID-19). We previously performed a genome-wi
Externí odkaz:
https://doaj.org/article/c10dd58b10dd439eb9610eccf28fbb91
Autor:
Neal G Ravindra, Mia Madel Alfajaro, Victor Gasque, Nicholas C Huston, Han Wan, Klara Szigeti-Buck, Yuki Yasumoto, Allison M Greaney, Victoria Habet, Ryan D Chow, Jennifer S Chen, Jin Wei, Renata B Filler, Bao Wang, Guilin Wang, Laura E Niklason, Ruth R Montgomery, Stephanie C Eisenbarth, Sidi Chen, Adam Williams, Akiko Iwasaki, Tamas L Horvath, Ellen F Foxman, Richard W Pierce, Anna Marie Pyle, David van Dijk, Craig B Wilen
Publikováno v:
PLoS Biology, Vol 19, Iss 3, p e3001143 (2021)
There are currently limited Food and Drug Administration (FDA)-approved drugs and vaccines for the treatment or prevention of Coronavirus Disease 2019 (COVID-19). Enhanced understanding of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Externí odkaz:
https://doaj.org/article/953d8b25aa2b462bb1a23148fd6012d7
Autor:
Jin Wei, Ajinkya Patil, Clayton K. Collings, Mia Madel Alfajaro, Yu Liang, Wesley L. Cai, Madison S. Strine, Renata B. Filler, Peter C. DeWeirdt, Ruth E. Hanna, Bridget L. Menasche, Arya Ökten, Mario A. Peña-Hernández, Jon Klein, Andrew McNamara, Romel Rosales, Briana L. McGovern, M. Luis Rodriguez, Adolfo García-Sastre, Kris M. White, Yiren Qin, John G. Doench, Qin Yan, Akiko Iwasaki, Thomas P. Zwaka, Jun Qi, Cigall Kadoch, Craig B. Wilen
Publikováno v:
Nature Genetics. 55:471-483
Identification of host determinants of coronavirus infection informs mechanisms of viral pathogenesis and can provide new drug targets. Here we demonstrate that mammalian SWItch/Sucrose Non-Fermentable (mSWI/SNF) chromatin remodeling complexes, speci
Autor:
Madison S. Strine, Wesley L. Cai, Jin Wei, Mia Madel Alfajaro, Renata B. Filler, Scott B. Biering, Sylvia Sarnik, Ajinkya Patil, Kasey S. Cervantes, Clayton K. Collings, Peter C. DeWeirdt, Ruth E. Hanna, Kevin Schofield, Christopher Hulme, Silvana Konermann, John G. Doench, Patrick D. Hsu, Cigall Kadoch, Qin Yan, Craig B. Wilen
Identifying host genes essential for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has the potential to reveal novel drug targets and further our understanding of coronavirus disease 2019 (COVID-19). We previously performed a genome-wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4daff4ea1bbb6b966be856a427f6fc8
https://doi.org/10.1101/2022.09.13.507833
https://doi.org/10.1101/2022.09.13.507833
Autor:
Andrew J. Sharon, Heather A. Filyk, Nicolette M. Fonseca, Rachel L. Simister, Renata B. Filler, Wallace Yuen, Blair K. Hardman, Hannah G. Robinson, Jung Hee Seo, Joana Rocha-Pereira, Ian Welch, Johan Neyts, Craig B. Wilen, Sean A. Crowe, Lisa C. Osborne
Publikováno v:
J Virol
Recent evidence indicates that viral components of the microbiota can contribute to intestinal homeostasis and protection from local inflammatory or infectious insults. However, host-derived mechanisms that regulate the virome remain largely unknown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5f54eafef4a73b135b0314de7dc8a8c
https://europepmc.org/articles/PMC8941907/
https://europepmc.org/articles/PMC8941907/
Autor:
Jennifer S. Chen, Ryan D. Chow, Eric Song, Tianyang Mao, Benjamin Israelow, Kathy Kamath, Joel Bozekowski, Winston A. Haynes, Renata B. Filler, Bridget L. Menasche, Jin Wei, Mia Madel Alfajaro, Wenzhi Song, Lei Peng, Lauren Carter, Jason S. Weinstein, Uthaman Gowthaman, Sidi Chen, Joe Craft, John C. Shon, Akiko Iwasaki, Craig B. Wilen, Stephanie C. Eisenbarth
Publikováno v:
Sci Immunol
T follicular helper (T FH ) cells are the conventional drivers of protective, germinal center (GC)–based antiviral antibody responses. However, loss of T FH cells and GCs has been observed in patients with severe COVID-19. As T cell–B cell intera
Autor:
Jason S. Weinstein, Lauren Carter, Benjamin Israelow, Tianyang Mao, Wenzhi Song, Sidi Chen, Bridget L. Menasche, Jennifer S. Chen, Craig B. Wilen, John Shon, Ryan D. Chow, Renata B. Filler, Uthaman Gowthaman, Akiko Iwasaki, Joel Bozekowski, Winston A. Haynes, Lei Peng, Joe Craft, Kathy Kamath, Eric Song, Jin Wei, Stephanie C. Eisenbarth, Mia Madel Alfajaro
T follicular helper (Tfh) cells are the conventional drivers of protective, germinal center (GC)-based antiviral antibody responses. However, loss of Tfh cells and GCs has been observed in patients with severe COVID-19. As T cell-B cell interactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a53b56b5d2776644b7bbe4fbdd36ad4
https://doi.org/10.1101/2021.06.10.447982
https://doi.org/10.1101/2021.06.10.447982
Autor:
Roch K. Dabiré, Arnau Casanovas-Massana, Amy K. Bei, Aaron M. Ring, Akiko Iwasaki, Renata B. Filler, Amadou Moctar Mbaye, Daniel Hodson, Sarah Lapidus, Babacar Diouf, Madison S. Strine, Inés Vigan-Womas, Juan Carlos Quintero Vélez, Choukri Ben-Mamoun, Kathy Kamath, Yile Dai, Ousmane Faye, Albert I. Ko, Alassane Mbengue, Seynabou D. Sene, Nivison Nery, Michael Cappello, Baba Dieye, Federico Costa, Rokhaya Faye, Khadidiatou Mangou, Craig B. Wilen, Jason R. Andrews, Jon Klein, Fabrice A. Somé, Yannick Mbarga, Mitermayer G. Reis, Michael T. Wilson, Adam J. Moore, Carolina Lucas, Elisabeth Baum-Jones, Awa B. Deme, Fatoumata Diallo, M. Catherine Muenker, Amadou A. Sall, Younous Diedhiou, Mariama N. Pouye, Aida Sadikh Badiane, Ariktha Srivathsan, Moussa Moïse Diagne, Cheikh Tidiane Diagne, Yap Boum, Mouhamad Sy, Ben Z. Katz, John Shon, Carole Else Eboumbou Moukoko, Ibrahima Ndiaye, Bacary D. Sadio, Daouda Ndiaye, Sunil Parikh, Feimei Liu, Jean-Bosco Ouédraogo, Adam V. Wisnewski, Melissa Campbell, John D. Huck
Publikováno v:
medRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Individuals with acute malaria infection generated high levels of antibodies that cross-react with the SARS-CoV-2 Spike protein. Cross-reactive antibodies specifically recognized the sialic acid moiety on N-linked glycans of the Spike protein and do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::351eccfac9c2d67fae993b20f892e630
https://doi.org/10.1101/2021.05.10.21256855
https://doi.org/10.1101/2021.05.10.21256855
Autor:
Andrew J Sharon, Heather A Filyk, Nicolette M Fonseca, Rachel L Simister, Renata B Filler, Wallace Yuen, Blair K Hardman, Hannah G Robinson, Jung Hee Seo, Joana Rocha-Pereira, Ian Welch, Johan Neyts, Craig B Wilen, Sean A Crowe, Lisa C Osborne
Publikováno v:
The Journal of Immunology. 208:182.04-182.04
Recent evidence indicates that viral components of the microbiota can contribute to intestinal homeostasis and protection from local inflammatory or infectious insults. However, host-derived mechanisms that regulate the virome remain largely unknown.