Detection and Quantification of ctDNA for Longitudinal Monitoring of Treatment in Non-Small Cell Lung Cancer Patients Using a Universal Mutant Detection Assay by Denaturing Capillary Electrophoresis

Autor: Lucie Benesova, Renata Ptackova, Tereza Halkova, Anastasiya Semyakina, Martin Svaton, Ondrej Fiala, Milos Pesek, Marek Minarik

Publikováno v: Pathology and Oncology Research, Vol 28 (2022)

Background: Observation of anticancer therapy effect by monitoring of minimal residual disease (MRD) is becoming an important tool in management of non-small cell lung cancer (NSCLC). The approach is based on periodic detection and quantification of

Externí odkaz: https://doaj.org/article/089f2946a5c14fe4914df4dad2fe7b16

Circulating Tumor DNA correlates with Lactate Dehydrogenase, CYFRA 21-1, and CRP levels in patients with advanced NSCLC

Autor: Marcela Buresova, Lucie Benesova, Marek Minarik, Renata Ptackova, Tereza Halkova, Petr Hosek, Jan Baxa, Milos Pesek, Martin Svaton, Ondrej Fiala

Publikováno v: Journal of Cancer. 14(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a1378d68f543fe8995a92e51d46b9fe
https://pubmed.ncbi.nlm.nih.gov/36605490

Combination of Circulating Tumour DNA and

Autor: Ondrej, Fiala, Jan, Baxa, Martin, Svaton, Lucie, Benesova, Renata, Ptackova, Tereza, Halkova, Marek, Minarik, Petr, Hosek, Marcela, Buresova, Jindrich, Finek, Jiri, Ferda, Milos, Pesek

Publikováno v: Cancer Genomics Proteomics

Background/Aim: Circulating tumour DNA (ctDNA) represents an emerging biomarker in non-small cell lung cancer (NSCLC). We focused on the combination of ctDNA and positron emission tomography/computed tomography (PET/CT) in the follow-up monitoring of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f2cdad7f836a4c8033cac0913dad5ec2
https://pubmed.ncbi.nlm.nih.gov/35181593

Gliotoxin, identified from a screen of fungal metabolites, disrupts 7SK snRNP, releases P-TEFb, and reverses HIV-1 latency

Autor: Anton Škríba, Abdullah M. S. Al-Hatmi, Annelies Verbon, Vladimír Havlíček, Tokameh Mahmoudi, Elisa De Crignis, Mohammad Javad Najafzadeh, Raquel Crespo, Tsung Wai Kan, Renata Ptackova, Robert-Jan Palstra, Miroslav Sulc, Enrico Ne, Joyce Kang, Michael Roling, Casper Rokx, Elizabeth LeMasters, Peter D. Katsikis, Wilfred F. J. van IJcken, Joyce H.G. Lebbink, Sybren de Hoog, Pritha Biswas, Mateusz Stoszko, Yvonne M. Mueller, Alessia Bertoldi

Publikováno v: Science Advances, 6
Science Advances, 6, 33
Science Advances
Science advances, 6(33):eaha6617. American Association for the Advancement of Science

Gliotoxin, identified from a screen of fungal metabolites, disrupts 7SK snRNP, releases P-TEFb, and reverses HIV-1 latency.
A leading pharmacological strategy toward HIV cure requires “shock” or activation of HIV gene expression in latently

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b739cee81da4c1e56b8cefe7393efa3e
https://pubmed.ncbi.nlm.nih.gov/32851167

Abstract 724: Application of oncoMonitor™ ctDNA tracking technology for monitoring of therapy and early detection of recurrence in metastatic colorectal cancer

Autor: Jiri Pudil, Marek Minarik, Lubos Petruzelka, Jaromir Simsa, Tereza Halkova, Miroslav Ryska, Lucie Benesova, Miroslav Levy, Jiri Hoch, Barbora Belsanova, Renata Ptackova, Filip Pazdirek

Publikováno v: Cancer Research. 80:724-724

Introduction: Liquid biopsy based on detection of circulating tumor DNA (circulating-tumor DNA, ctDNA) is finding new applications in clinical management of solid cancers. From the initial use as an alternative to classical tissue biopsy for investig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed41dcf7308789bc493b68cd537c8788
https://doi.org/10.1158/1538-7445.am2020-724