Ligand Growing Experiments Suggested 4-amino and 4-ureido pyridazin-3(2H)-one as Novel Scaffold for FABP4 Inhibition

Autor: Letizia Crocetti, Giuseppe Floresta, Chiara Zagni, Divya Merugu, Francesca Mazzacuva, Renan Rodrigues de Oliveira Silva, Claudia Vergelli, Maria Paola Giovannoni, Agostino Cilibrizzi

Publikováno v: Pharmaceuticals, Vol 15, Iss 11, p 1335 (2022)

Fatty acid binding protein (FABP4) inhibitors are of synthetic and therapeutic interest and ongoing clinical studies indicate that they may be a promise for the treatment of cancer, as well as other diseases. As part of a broader research effort to d

Externí odkaz: https://doaj.org/article/9b4e32591ce1407daa77833857b5ce5d

Flow synthesis of n-substituted 5-benzylidinethiazolidine-2,4-dione

Autor: Renan Rodrigues de Oliveira Silva, Mauri Sergio Alves Palma

Publikováno v: STUDIES IN ENGINEERING AND EXACT SCIENCES. 3:385-402

Process intensification based on micro reactor technology allows safe manner and a new pathway to run organic synthesis due to its intrinsic characteristics, and can reduce time-to-market of new drugs. The main objective of this work was to study the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6359a96818900efd4312fbad877ef6b2
https://doi.org/10.54021/sesv3n2-006

How chemical engineers can contribute to fight the COVID-19

Autor: Giovanni Alexsander Silva Lima, Marcos R.P. de Souza, Mariana G. M. Lopes, Dirceu Noriler, Harrson S. Santana, Renan Rodrigues de Oliveira Silva, Johmar Souza, Joao L. Silva Jr, Guadalupe Munhoz, Mauri Sérgio Alves Palma, Osvaldir Pereira Taranto, Wilson L.V. Nakano

Publikováno v: Journal of the Taiwan Institute of Chemical Engineers
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Highlights • Vaccine development and medication used in medical protocols were described. • The main fluid dynamic of transmission routes were elucidated. • Successful applications of reverse engineering and 3D printing were reported. • The s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5574a279853fbf26b4ccb6da6022d581
http://europepmc.org/articles/PMC7698668

Flow synthesis of a thiazolidine drug intermediate in capillary microreactors

Autor: Paulo Victor Cuesta Calvo, Milena Fernandes da Silva, Attilio Converti, Carlo Solisio, Mauri Sérgio Alves Palma, Renan Rodrigues de Oliveira Silva

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e7fba2c5fae91a77d92b0e7a6a85722

Microreactor technology as a tool for the synthesis of a glitazone drug intermediate

Autor: Milena Fernandes da Silva, Danilo da Silva Pinheiro, Renan Rodrigues de Oliveira Silva, Paulo Victor Cuesta Calvo, Attilio Converti, Mauri Sérgio Alves Palma

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca3d12b90bf697903a515861f6c73e3c