Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Renan Borowicz"'
Autor:
Ricarda Schlenz, Stefan Kaulfuss, Renan Borowicz, Andreas Janzer, Andrea Triller, Gerhard Siemeister, Sven Christian, Katrin Gutberlet, Ashley Eheim, Katrin Jaensch, Michael Jeffers
Publikováno v:
Cancer Research. 81:2077-2077
Introduction: BAY2402234 is a potent and specific orally administered inhibitor of dihydroorotate dehydrogenase (DHODH) which showed anti-tumor activity in preclinical models of AML and is under clinical evaluation in myeloid malignancies (NCT0340472
Autor:
Stefan Pusch, Julia Zaman, Andreas von Deimling, Jennifer Höde, Anuhar Chaturvedi, Renan Borowicz, Ricarda Biber, Holger Hess-Stumpp, Michael Heuser, Stefan Kaulfuss
Publikováno v:
Cancer Research. 79:2182-2182
Background: Isocitrate dehydrogenase (IDH) mutations are drivers of different tumors. The IDH1R132 mutation is frequently found in glioma (80%), chondrosarcoma (CS, 45%), intrahepatic cholangiocarcinoma (ICC, 20%), acute myeloid leukemia (AML, 7%), a