Global profiling of distinct cysteine redox forms reveals wide-ranging redox regulation in C. elegans

Autor: Jin Meng, Ling Fu, Keke Liu, Caiping Tian, Ziyun Wu, Youngeun Jung, Renan B. Ferreira, Kate S. Carroll, T. Keith Blackwell, Jing Yang

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Reversible cysteine oxidative modifications have emerged as important mechanisms that alter protein function. Here the authors globally assess the cysteine reactivity and an array of cysteine oxidative modifications in C. elegans, providing insights

Externí odkaz: https://doaj.org/article/4eb29991d93a4c36bb272348ea5b3ccc

Endogenous SO2-dependent Smad3 redox modification controls vascular remodeling

Autor: Yaqian Huang, Zongmin Li, Lulu Zhang, Huan Tang, Heng Zhang, Chu Wang, Selena Ying Chen, Dingfang Bu, Zaifeng Zhang, Zhigang Zhu, Piaoliu Yuan, Kun Li, Xiaoqi Yu, Wei Kong, Chaoshu Tang, Youngeun Jung, Renan B. Ferreira, Kate S. Carroll, Junbao Du, Jing Yang, Hongfang Jin

Publikováno v: Redox Biology, Vol 41, Iss , Pp 101898- (2021)

Sulfur dioxide (SO2) has emerged as a physiological relevant signaling molecule that plays a prominent role in regulating vascular functions. However, molecular mechanisms whereby SO2 influences its upper-stream targets have been elusive. Here we sho

Externí odkaz: https://doaj.org/article/deaf16baf3ea4fd992d5fdea6eaf8d48

Nucleophilic covalent ligand discovery for the cysteine redoxome

Autor: Ling Fu, Youngeun Jung, Caiping Tian, Renan B. Ferreira, Ruifeng Cheng, Fuchu He, Jing Yang, Kate S. Carroll

Publikováno v: Nature Chemical Biology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5753a68cf9918b0e7938bb917daa3de3
https://doi.org/10.1038/s41589-023-01330-5

Global profiling of distinct cysteine redox forms reveals wide-ranging redox regulation in C. elegans

Autor: Jing Yang, T. Keith Blackwell, Renan B. Ferreira, Youngeun Jung, Ling Fu, Ziyun Wu, Jin Meng, Caiping Tian, Keke Liu, Kate S. Carroll

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications

Post-translational changes in the redox state of cysteine residues can rapidly and reversibly alter protein functions, thereby modulating biological processes. The nematode C. elegans is an ideal model organism for studying cysteine-mediated redox si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec495804e0cd676c0ae00240764d05f9
https://doaj.org/article/4eb29991d93a4c36bb272348ea5b3ccc

Inhibitors of ERp44, PDIA1, and AGR2 induce disulfide-mediated oligomerization of Death Receptors 4 and 5 and cancer cell death

Autor: Mary E. Law, Chi Wu Chiang, Sadie F. DePeter, Elham Yaaghubi, Sixue Chen, Peter Nørgaard, Bradley J. Davis, Christopher M. Schilson, Ronald K. Castellano, Brian K. Law, Renan B. Ferreira, Jin Koh, Coy D. Heldermon, Amanda F. Ghilardi

Publikováno v: Law, M E, Yaaghubi, E, Ghilardi, A F, Davis, B J, Ferreira, R B, Koh, J, Chen, S, DePeter, S F, Schilson, C M, Chiang, C W, Heldermon, C D, Nørgaard, P, Castellano, R K & Law, B K 2022, ' Inhibitors of ERp44, PDIA1, and AGR2 induce disulfide-mediated oligomerization of Death Receptors 4 and 5 and cancer cell death ', Cancer Letters, vol. 534, 215604 . https://doi.org/10.1016/j.canlet.2022.215604

Breast cancer mortality remains unacceptably high, indicating a need for safer and more effective therapeutic agents. Disulfide bond Disrupting Agents (DDAs) were previously identified as a novel class of anticancer compounds that selectively kill ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29acbb40a00907464bfc8ac10a6fd1a2
https://curis.ku.dk/ws/files/358644313/2021.01.13.426390v3.full.pdf