Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Renaldo Mendoza"'
Autor:
Jie Wang, Edmund D. Matayoshi, Edward T. Olejniczak, Ana Pereda-Lopez, Philip J. Hajduk, Liping Yu, Chaohong Sun, Eric J. Hebert, Renaldo Mendoza
Publikováno v:
Protein Science. 16:2502-2509
Calsenilin is a member of the recoverin branch of the EF-hand superfamily that is reported to interact with presenilins, regulate prodynorphin gene expression, modulate voltage-gated Kv4 potassium channel function, and bind to neurotoxins. Calsenilin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b1e43e94b5f991d8439ab00ccf8c258
https://doi.org/10.1110/ps.072928007
https://doi.org/10.1110/ps.072928007
Autor:
Robert W. Johnson, Edward T. Olejniczak, Renaldo Mendoza, Yaya Liu, Jun Chen, Darlene A Cothron, Philip J. Hajduk, Claude G. Lerner, Jeffrey R. Huth
Publikováno v:
Journal of the American Chemical Society. 127:217-224
High-throughput screening (HTS) of large compound collections typically results in numerous small molecule hits that must be carefully evaluated to identify valid drug leads. Although several filtering mechanisms and other tools exist that can assist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca8ebf25120a8740c643660a6a11706e
https://doi.org/10.1021/ja0455547
https://doi.org/10.1021/ja0455547
Autor:
Mark G. Bures, Andrew M. Petros, Jeffrey R. Huth, Yvonne C. Martin, Philip J. Hajduk, Stephen W. Fesik, Renaldo Mendoza
Publikováno v:
Journal of Computer-Aided Molecular Design. 17:93-102
A detailed chemometric analysis of ligand binding to domain-3A of human serum albumin is described. NMR and fluorescence data on a set of 889 chemically diverse compounds were used to develop a group contribution model based on 74 chemical fragments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f30a518dac00ba259ada0a85328fadc1
https://doi.org/10.1023/a:1025305520585
https://doi.org/10.1023/a:1025305520585
Autor:
Ana Pereda-Lopez, Yaya Liu, Andrew M. Petros, Sanjay C. Panchal, Rama Thimmapaya, Renaldo Mendoza, Chaohong Sun, Walter F. Leise, Carol S. Surowy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5248-5250
NMR-based screening of protein targets has become a well established part of the drug discovery process especially with respect to fragments. However, as target size increases the two-dimensional spectra typically used for such screening become more
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc330c39f21c88a5f0b62424e147f6c
https://doi.org/10.1016/j.bmcl.2011.07.039
https://doi.org/10.1016/j.bmcl.2011.07.039
Autor:
Jeffrey R. Huth, Thomas W. von Geldern, Edward T. Olejniczak, Gang Liu, Devries Peter J, Renaldo Mendoza, Stephen W. Fesik, Gregory F. Okasinski, Sandra Leitza, Edward B. Reilly
Publikováno v:
Journal of Medicinal Chemistry. 44:1202-1210
The interaction between leukocyte function-associated antigen-1 (LFA-1) and intracellular adhesion molecule-1 (ICAM-1) has been implicated in inflammatory and immune diseases. Recently, a novel series of p-arylthio cinnamides has been described as po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::424d89fb003952a37d15fc97e4378aa1
https://doi.org/10.1021/jm000503f
https://doi.org/10.1021/jm000503f
Autor:
and Stephen F. Betz, Renaldo Mendoza, Jamey Mack, Philip J. Hajduk, Stephen W. Fesik, David J. Augeri, Jianguo Yang
Publikováno v:
Journal of the American Chemical Society. 122:7898-7904
A method is described for NMR-based screening that involves monitoring the 13C/1H chemical shift changes of a protein selectively labeled with 13C at the methyl groups of valine, leucine, and isoleucine (δ1 only). Using this approach, the sensitivit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60642108bf591be70667e89ed8902e98
https://doi.org/10.1021/ja000350l
https://doi.org/10.1021/ja000350l
Autor:
Renaldo Mendoza, Andrew M. Petros, Jeffrey R. Huth, Chaohong Sun, Stephen W. Fesik, Saul H. Rosenberg, Karl A. Walter, Philip J. Hajduk, Sarah A. Dorwin, Cheol-Min Park, Wang Xilu, Thorsten Oost, Paul Nimmer, Emily Gramling, Haichao Zhang, Hong Ding, Uri S. Ladror, Steven W. Elmore, Jamey Mack
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(22)
The Bcl-2 family of proteins plays a major role in the regulation of apoptosis, or programmed cell death. Overexpression of the anti-apoptotic members of this family (Bcl-2, Bcl-xL, and Mcl-1) can render cancer cells resistant to chemotherapeutic age
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266548bc1402d6d8168c82edd71ea263
https://pubmed.ncbi.nlm.nih.gov/20870405
https://pubmed.ncbi.nlm.nih.gov/20870405
Autor:
Steve Anderson, Akhter Molla, Robert J Carrick, Jeffrey R. Huth, Karl A. Walter, Leo W. Barrett, Robert P. Meadows, Kent D. Stewart, Dale J. Kempf, Paul L. Richardson, Clarence J. Maring, Vincent S. Stoll, Edmund D. Matayoshi, Teresa I. Ng, Edward T. Olejniczak, William E. Kohlbrenner, Renaldo Mendoza, Jean M. Severin, Hongmei Mo, Keith F. McDaniel, Rebecca Hutchinson
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(2)
The ectodomain of HIV-1 gp41 mediates the fusion of viral and host cellular membranes. The peptide-based drug Enfuvirtide 1 is precedent that antagonists of this fusion activity may act as anti HIV-agents. Here, NMR screening was used to discover non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5d850f797b63ddc2ee55406990346b
https://pubmed.ncbi.nlm.nih.gov/20004576
https://pubmed.ncbi.nlm.nih.gov/20004576
Autor:
Karl A. Walter, Jeffrey R. Huth, Renaldo Mendoza, Sarah A. Dorwin, Jamey Mack, Uri S. Ladror, Danying Song, Philip J. Hajduk, Jean M. Severin, Diane Bartley, Candice L. Black-Schaefer
Publikováno v:
Chemical research in toxicology. 20(12)
We have recently reported on the development of a La assay to detect reactive molecules by nuclear magnetic resonance (ALARM NMR) to detect reactive false positive hits from high-throughput screening, in which we observed a surprisingly large number
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c804192eb2e26635dbfaea8625341861
https://pubmed.ncbi.nlm.nih.gov/18001056
https://pubmed.ncbi.nlm.nih.gov/18001056
Autor:
Irene Collins, G. Marius Clore, Philip J. Hajduk, Kenneth M. Comess, David Levens, Jamey Mack, Steven W. Muchmore, Liping Yu, Binumol Isaac, Demetrios T. Braddock, Renaldo Mendoza, Jeffrey R. Huth, Stephen W. Fesik
Publikováno v:
Journal of medicinal chemistry. 47(20)
Reversal of aberrant gene expression that is induced by the proto-oncogene c-myc is likely to be effective for treating a variety of tumors that rely on this pathway for growth. One strategy to down-regulate the c-myc pathway is to target transcripti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::145d376006b7873b8134a5cf32a47859
https://pubmed.ncbi.nlm.nih.gov/15369388
https://pubmed.ncbi.nlm.nih.gov/15369388