Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Renae M, Ryan"'
Autor:
Yi C. Zeng, Meghna Sobti, Ada Quinn, Nicola J. Smith, Simon H. J. Brown, Jamie I. Vandenberg, Renae M. Ryan, Megan L. O’Mara, Alastair G. Stewart
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Organic Cation Transporter 1 (OCT1) plays a crucial role in hepatic metabolism by mediating the uptake of a range of metabolites and drugs. Genetic variations can alter the efficacy and safety of compounds transported by OCT1, such as those
Externí odkaz:
https://doaj.org/article/7d16bee6f8884657b1aa4c5b3640243f
Autor:
Qianyi Wu, Azman Akhter, Shashank Pant, Eunjoo Cho, Jin Xin Zhu, Alastair Garner, Tomoko Ohyama, Emad Tajkhorshid, Donald J. van Meyel, Renae M. Ryan
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 7 (2022)
Glutamate is the predominant excitatory neurotransmitter in the mammalian central nervous system (CNS). Excitatory amino acid transporters (EAATs) regulate extracellular glutamate by transporting it into cells, mostly glia, to terminate neurotransmis
Externí odkaz:
https://doaj.org/article/49af9ee812bc490baa7336527ea0c147
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Neurotransmitter transporters limit spillover between synapses and maintain the extracellular neurotransmitter concentration at low yet physiologically meaningful levels. They also exert a key role in providing precursors for neurotransmitter biosynt
Externí odkaz:
https://doaj.org/article/6fe57dc3f16d43b19f31eb00c3c276ff
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Cancer cells are reliant on nutrients such as glutamine, which enter the cell via the alanine/serine/cysteine transporter 2 (ASCT2). Here, authors use crystallography to show which amino-acid residues in the substrate-binding site are responsible for
Externí odkaz:
https://doaj.org/article/ab0f2812dab54201a550d895712c496d
Autor:
Shannon N Mostyn, Katie A Wilson, Alexandra Schumann-Gillett, Zachary J Frangos, Susan Shimmon, Tristan Rawling, Renae M Ryan, Megan L O'Mara, Robert J Vandenberg
Publikováno v:
eLife, Vol 8 (2019)
The treatment of chronic pain is poorly managed by current analgesics, and there is a need for new classes of drugs. We recently developed a series of bioactive lipids that inhibit the human glycine transporter GlyT2 (SLC6A5) and provide analgesia in
Externí odkaz:
https://doaj.org/article/e4b5579816404d49a4828b1847e2f1d9
Autor:
Kate P. Nolan, Josep Font, Athavan Sresutharsan, Michael P. Gotsbacher, Christopher J. M. Brown, Renae M. Ryan, Rachel Codd
Publikováno v:
ACS Chemical Biology. 17:426-437
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0feb10f7117e5c58720977bfc0ea4dd9
https://doi.org/10.1021/acschembio.1c00879
https://doi.org/10.1021/acschembio.1c00879
Autor:
Alastair G. Stewart, Emad Tajkhorshid, Rosemary J. Cater, Renae M. Ryan, Josep Font, Qianyi Wu, Ichia Chen, Shashank Pant, Robert J. Vandenberg, Meghna Sobti
Publikováno v:
Nature
Glutamate is the most abundant excitatory neurotransmitter in the central nervous system, and its precise control is vital to maintain normal brain function and to prevent excitotoxicity1. The removal of extracellular glutamate is achieved by plasma-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb0644b0b58b484458adc5bf3841f665
http://europepmc.org/articles/PMC7954978
http://europepmc.org/articles/PMC7954978
Autor:
Alastair Garner, Jin Xin Zhu, Qianyi Wu, Emad Tajkhorshid, Don J. Van Meyel, Shashank Pant, Renae M. Ryan, Tomoko Ohyama, Eunjoo Cho, Azman Akhter
Publikováno v:
Journal of Clinical Investigation. 132
Glutamate is the predominant excitatory neurotransmitter in the mammalian central nervous system (CNS). Excitatory Amino Acid Transporters (EAATs) regulate extracellular glutamate by transporting it into cells, mostly glia, to terminate neurotransmis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd4ad5cd2e51244be3c767de6c3485ef
https://doi.org/10.1172/jci154891
https://doi.org/10.1172/jci154891
Autor:
Nandhitha Subramanian, Amanda J Scopelitti, Jane E Carland, Renae M Ryan, Megan L O'Mara, Robert J Vandenberg
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157583 (2016)
The Na+/Cl- dependent glycine transporters GlyT1 and GlyT2 regulate synaptic glycine concentrations. Glycine transport by GlyT2 is coupled to the co-transport of three Na+ ions, whereas transport by GlyT1 is coupled to the co-transport of only two Na
Externí odkaz:
https://doaj.org/article/95de3807aa934c75a109fe1f2efdbb41
Autor:
Nandhitha Subramanian, Amanda J Scopelliti, Jane E Carland, Renae M Ryan, Megan L O'Mara, Robert J Vandenberg
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159896 (2016)
[This corrects the article DOI: 10.1371/journal.pone.0157583.].
Externí odkaz:
https://doaj.org/article/2a486b1f6fb9412eb92a93b08f90ef2f