Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Rena Ning Ren"'
Autor:
Mark T. Goulet, Patrice H. Gibbons, Yi Tien Yang, Wallace T. Ashton, Kang Cheng, George R. Mount, Bridget Butler, Rosemary Sisco, Jane-Ling Lo, Joel B. Yudkovitz, Rena Ning Ren
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1727-1731
A pyridine side-chain terminus has been incorporated into the indole-5-carboxamide and indole-5-acetamide series of GnRH antagonists. Potent activity was observed in binding and functional assays. Certain branched or cyclic tertiary amides were ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd14f4097468ba547271025f73a8dfbd
https://doi.org/10.1016/s0960-894x(01)00275-x
https://doi.org/10.1016/s0960-894x(01)00275-x
Autor:
An-Hua Mao, Yi Tien Yang, Rena Ning Ren, Mitree M. Ponpipom, Stella H. Vincent, Jisong Cui, Joel B. Yudkovitz, Robert L. Bugianesi, George R. Mount, Mellissa Creighton, Kang Cheng, Joseph P. Simeone, Jane-Ling Lo, Mark T. Goulet
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(22)
The synthesis of a number of indole GnRH antagonists is described. Oxidation of the pyridine ring nitrogen, combined with alkylation at the two position, led to a compound with an excellent in vitro activity profile as well as oral bioavailability in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f0d9016909508805fb7efc6835dbb42
https://pubmed.ncbi.nlm.nih.gov/12392744
https://pubmed.ncbi.nlm.nih.gov/12392744
Autor:
Tsuei Ju Wu, An Hua Mao, Bindhu V. Karanam, Mark T. Goulet, Xiaolan Shen, Rena Ning Ren, Kang Cheng, George R. Mount, Joel B. Yudkovitz, Jisong Cui, Thomas F. Walsh, Kathryn A. Lyons, Matthew J. Wyvratt, Jonathan R. Young, Stella H. Vincent, Josephine R. Carlin, Song X. Huang, Yi Tien Yang
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(5)
A series of 2-arylindoles containing novel heteroaromatic substituents on the tryptamine tether, based on compound 1, was prepared and evaluated for their ability to act as gonadotropin releasing hormone (GnRH) antagonists. Successful modifications o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be551d8bebe4fcd25627e7c540845563
https://pubmed.ncbi.nlm.nih.gov/11859012
https://pubmed.ncbi.nlm.nih.gov/11859012
Autor:
Mark T. Goulet, Rosemary Sisco, Xiaolan Shen, Jisong Cui, An-Hua Mao, Bindhu V. Karanam, Kang Cheng, Gerard R. Kieczykowski, Tsuei-Ju Wu, Kathryn A. Lyons, Rena Ning Ren, Stella H. Vincent, George R. Mount, Yi Tien Yang, Josephine R. Carlin, Wallace T. Ashton, Joel B. Yudkovitz
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(19)
Stereospecific introduction of a methyl group to the indole-3-side chain enhanced activity in our tryptamine-derived series of GnRH receptor antagonists. Further improvements were achieved by variation of the bicyclic amino moiety of the tertiary ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62aa10fe83ceeb8e6e55192fca6d7d38
https://pubmed.ncbi.nlm.nih.gov/11551758
https://pubmed.ncbi.nlm.nih.gov/11551758