Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Rena G, Lapidus"'
Autor:
Dominique Bollino, Kanwal Hameed, Anusha Bhat, Arveen Zarrabi, Andrea Casildo, Xinrong Ma, Kayla M Tighe, Brandon Carter-Cooper, Erin T. Strovel, Rena G. Lapidus, Ashkan Emadi
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-12 (2024)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease without meaningful therapeutic options beyond the first salvage therapy. Targeting PDAC metabolism through amino acid restriction has emerged as a promising new stra
Externí odkaz:
https://doaj.org/article/525655e9405e4d5485db4d740e853fe2
Autor:
Kanwal M. Hameed, Dominique R. Bollino, Amol C. Shetty, Brandon Carter-Cooper, Rena G. Lapidus, Ashkan Emadi
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy characterized by disrupted blood cell production and function. Recent investigations have highlighted the potential of targeting glutamine metabolism as a promising therapeutic
Externí odkaz:
https://doaj.org/article/ebcdccd9bffb4a7fb14b950613351aac
Autor:
Diego de Miguel-Perez, Alessandro Russo, Oscar Arrieta, Murat Ak, Feliciano Barron, Muthukumar Gunasekaran, Priyadarshini Mamindla, Luis Lara-Mejia, Christine B. Peterson, Mehmet E. Er, Vishal Peddagangireddy, Francesco Buemi, Brandon Cooper, Paolo Manca, Rena G. Lapidus, Ru-Ching Hsia, Andres F. Cardona, Aung Naing, Sunjay Kaushal, Fred R. Hirsch, Philip C. Mack, Maria Jose Serrano, Vincenzo Adamo, Rivka R. Colen, Christian Rolfo
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-14 (2022)
Abstract Background Immune-checkpoint inhibitors (ICIs) changed the therapeutic landscape of patients with lung cancer. However, only a subset of them derived clinical benefit and evidenced the need to identify reliable predictive biomarkers. Liquid
Externí odkaz:
https://doaj.org/article/4c65ef22566e4f538c868b2b0b00c400
Autor:
Dominique Bollino, J. Preston Claiborne, Kanwal Hameed, Xinrong Ma, Kayla M. Tighe, Brandon Carter-Cooper, Rena G. Lapidus, Erin T. Strovel, Ashkan Emadi
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The impact of asparaginases on plasma asparagine and glutamine is well established. However, the effect of asparaginases, particularly those derived from Erwinia chrysanthemi (also called crisantaspase), on circulating levels of other amino acids is
Externí odkaz:
https://doaj.org/article/3adc67d2117c455686dc7b3a50c277d3
Autor:
Zejia Yang, Jipei Liao, Brandon A. Carter-Cooper, Rena G. Lapidus, Kevin J. Cullen, Hancai Dan
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-12 (2019)
Abstract Background We investigated the role of the ETS-1 transcription factor in Head and Neck Squamous Cell Carcinoma (HNSCC) in multiple cisplatin-resistant HNSCC cell lines. Methods We examined its molecular link with SRC and MEK/ERK pathways and
Externí odkaz:
https://doaj.org/article/b5fe2ee4171d4d008c916a2f7ab7acad
Autor:
N. Naganna, Clement Opoku-Temeng, Eun Yong Choi, Elizabeth Larocque, Elizabeth T. Chang, Brandon A. Carter-Cooper, Modi Wang, Sandra E. Torregrosa-Allen, Bennett D. Elzey, Rena G. Lapidus, Herman O. Sintim
Publikováno v:
EBioMedicine, Vol 40, Iss , Pp 231-239 (2019)
Background: Acute myeloid leukemia (AML) remains one of the most lethal, rarely cured cancers, despite decades of active development of AML therapeutics. Currently, the 5-year survival of AML patients is about 30% and for elderly patients, the rate d
Externí odkaz:
https://doaj.org/article/84513b90178c469e81d566cd4da53c11
Autor:
Maria R. Baer, Goutham Narla, Danilo Perrotti, Yin Wang, Jaya Sangodkar, Sandrine Niyongere, Rena G. Lapidus, Shivani Kapoor, Jonelle K. Lee, Christopher M. Bailey, Prerna Singh, Mario Scarpa
Supplementary Table S1. AML patients. Supplementary Table S2. RT-qPCR primers. Supplementary Table S3. IC50 concentrations (nM) of FLT3 inhibitors, PP2A activators and GSK-3beta inhibitors. Supplementary Figure S1. Concurrent PP2A-activating drug tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86eb9d3fab43e2d25f4450c2f3c42655
https://doi.org/10.1158/1535-7163.22522443
https://doi.org/10.1158/1535-7163.22522443
Autor:
Han C. Dan, Xuefeng Liu, Xinghuan Wang, Arif Hussain, Samusi Adediran, Eun Yong Choi, Peiyan Liu, Rena G. Lapidus, Yanting Zhang
Supplementary Figure S1. IKKβ is activated by Akt, mTORC1 and IKKα in prostate cancer PC3 cells; Supplementary Figure S2. Expressions of EMT- and stemness-related factors in tissue microarrays representative of different stages of prostate cancer;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a71bfc0a79849c3383295800dd6a5c4a
https://doi.org/10.1158/1535-7163.22507608.v1
https://doi.org/10.1158/1535-7163.22507608.v1
Autor:
Maria R. Baer, Goutham Narla, Danilo Perrotti, Yin Wang, Jaya Sangodkar, Sandrine Niyongere, Rena G. Lapidus, Shivani Kapoor, Jonelle K. Lee, Christopher M. Bailey, Prerna Singh, Mario Scarpa
Fms-like tyrosine-like kinase 3 internal tandem duplication (FLT3-ITD) is present in acute myeloid leukemia (AML) in 30% of patients and is associated with short disease-free survival. FLT3 inhibitor efficacy is limited and transient but may be enhan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2921d1b6556415df736f52ed8b400ce1
https://doi.org/10.1158/1535-7163.c.6543381.v1
https://doi.org/10.1158/1535-7163.c.6543381.v1
Autor:
Maria R. Baer, Danilo Perrotti, Adriana E. Tron, Dennis Huszar, Manfred Kraus, Eduardo Davila, Rossana Trotta, Mario Scarpa, Trevor J. Mathias, Rena G. Lapidus, Kshama A. Doshi, Patrick R. Baldwin, Karthika Natarajan, Shivani Kapoor
AZD1208 and quizartinib co-treatment was well tolerated in the orthotopic model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aa4dc3b4b50fe54ac11960a14462b2d
https://doi.org/10.1158/1078-0432.22463250.v1
https://doi.org/10.1158/1078-0432.22463250.v1