Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Rena A Mizrahi"'
Autor:
Rena A. Mizrahi, Wendy Y. Lin, Ashley Gras, Ariel R. Niedecken, Ellen K. Wagner, Sheila M. Keating, Nikita Ikon, Vishal A. Manickam, Michael A. Asensio, Jackson Leong, Angelica V. Medina-Cucurella, Emily Benzie, Kyle P. Carter, Yao Chiang, Robert C. Edgar, Renee Leong, Yoong Wearn Lim, Jan Fredrik Simons, Matthew J. Spindler, Kacy Stadtmiller, Nicholas Wayham, Dirk Büscher, Jose Vicente Terencio, Clara Di Germanio, Steven M. Chamow, Charles Olson, Paula A. Pino, Jun-Gyu Park, Amberlee Hicks, Chengjin Ye, Andreu Garcia-Vilanova, Luis Martinez-Sobrido, Jordi B. Torrelles, David S. Johnson, Adam S. Adler
Publikováno v:
Pathogens, Vol 11, Iss 7, p 806 (2022)
Conventionally, hyperimmune globulin drugs manufactured from pooled immunoglobulins from vaccinated or convalescent donors have been used in treating infections where no treatment is available. This is especially important where multi-epitope neutral
Externí odkaz:
https://doaj.org/article/30fbcf61da8b46ddab93ba7e247ee57f
Autor:
Nicholas P Wayham, Ariel R Niedecken, Jan Fredrik Simons, Yao Y Chiang, Angélica V Medina-Cucurella, Rena A Mizrahi, Ellen K Wagner, Ashley Gras, Ilana Segal, Peyton Witte, Alexis Enstrom, Aristea Bountouvas, Sabrina M Nelson, Tess Weinberger, David Tan, Michael A Asensio, Alagu Subramanian, Yoong Wearn Lim, Adam S Adler, Sheila M Keating
Publikováno v:
The Journal of Infectious Diseases.
Emerging variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) possess mutations that prevent antibody therapeutics from maintaining antiviral binding and neutralizing efficacy. Monoclonal antibodies (mAbs) shown to neutralize Wuha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2bfb36483accb547c694e3d560f93c3
https://doi.org/10.1093/infdis/jiad102
https://doi.org/10.1093/infdis/jiad102
Autor:
Christine V.F. Carrington, Steven M Chamow, Adam S. Adler, Matthew Adams, Sheila M. Keating, Emma Pearce, Ashley Gras, Robert C. Edgar, Charles Olson, Dirk Büscher, Jasmeen Saini, Kyle P Carter, Ariel R Niedecken, Heather E. Lynch, Rachel Mosher, Ellen K. Wagner, Vishal A. Manickam, Renee Leong, Bishal K. Gautam, Jan Fredrik Simons, Marcus O. Muench, Matthew J. Spindler, Jose Vicente Terencio, LaRee Tracy, Brendan Tinsley, Thomas H. Oguin, David S. Johnson, Yao Chiang, Nicholas Wayham, Everett Meyer, Rena A. Mizrahi, Anushka T. Ramjag, Carl A. Ross, Carina Vingsbo Lundberg, David Goldblatt, Matthew J Walch, Yoong Wearn Lim, Jackson Leong, Michael A. Asensio, Lucy Roalfe, Robert Jeanfreau, Emily Benzie, Christopher R. Bartley, Graham Simmons, Hayley Richardson, Bryan Monroe, Angélica V Medina-Cucurella, Kacy Stadtmiller
Publikováno v:
Nature biotechnology
Plasma-derived polyclonal antibody therapeutics, such as intravenous immunoglobulin, have multiple drawbacks, including low potency, impurities, insufficient supply, and batch-to-batch variation. Here we describe a microfluidics and molecular genomic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8917bb26c73ba55ef1640d50a52b47
http://europepmc.org/articles/PMC8355030
http://europepmc.org/articles/PMC8355030
Autor:
Angélica V. Medina-Cucurella, Rena A. Mizrahi, Michael A. Asensio, Robert C. Edgar, Jackson Leong, Renee Leong, Yoong Wearn Lim, Ayla Nelson, Ariel R. Niedecken, Jan Fredrik Simons, Matthew J. Spindler, Kacy Stadtmiller, Nicholas Wayham, Adam S. Adler, David S. Johnson
Publikováno v:
Antibodies, Vol 8, Iss 1, p 17 (2019)
To discover therapeutically relevant antibody candidates, many groups use mouse immunization followed by hybridoma generation or B cell screening. One modern approach is to screen B cells by generating natively paired single chain variable fragment (
Externí odkaz:
https://doaj.org/article/4a06d9d0e77d4bfe97384b6e3af1b455
Autor:
Erica L Stone, Kyle P Carter, Ellen K Wagner, Michael A Asensio, Emily Benzie, Yao Yuan Chiang, Garry L Coles, Chelsea Edgar, Bishal K Gautam, Ashley Gras, Jackson Leong, Renee Leong, Vishal A Manickam, Rena A Mizrahi, Ariel R Niedecken, Jasmeen Saini, Savreet K Sandhu, Jan Fredrick Simons, Kacy Stadtmiller, Brendan Tinsley, LaRee Tracy, Nicholas P Wayham, Yoong Wearn Lim, Adam S Adler, David S Johnson
Publikováno v:
Cancer Immunology Research. 10:A32-A32
Anti-CTLA-4 antibodies such as ipilimumab were among the first immuno-oncology agents to show significantly improved outcomes for patients. However, existing anti-CTLA-4 therapies fail to induce a response in a majority of patients and can induce sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa01c69f115a5cbabbd7bbb2e0b1ad8b
https://doi.org/10.1158/2326-6074.tumimm22-a32
https://doi.org/10.1158/2326-6074.tumimm22-a32
Autor:
Kyle P Carter, Yao Y. Chiang, Vishal A. Manickam, Emily Benzie, Nicholas Wayham, David S. Johnson, Rena A. Mizrahi, Jasmeen Saini, Garry L. Coles, Savreet K. Sandhu, Eric A. Stone, Jan Fredrick Simons, Adam S. Adler, Ellen K. Wagner, Ashley Gras, Chelsea Edgar, LaRee Tracy, Brendan Tinsley, Jackson Leong, Kacy Stadtmiller, Ariel R Niedecken, Renee Leong, Yoong Wearn Lim, Bishal K. Gautam, Michael A. Asensio
Anti-CTLA-4 antibodies such as ipilimumab were among the first immune-oncology agents to show significantly improved outcomes for patients. However, existing anti-CTLA-4 therapies fail to induce a response in a majority of patients and can induce sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f6edafd41945bb756870a8746a1366a
https://doi.org/10.1101/2021.07.12.452090
https://doi.org/10.1101/2021.07.12.452090
Autor:
Everett Meyer, David S. Johnson, Lucy Roalfe, Rena A. Mizrahi, Terencio Jv, David Goldblatt, Ariel R Niedecken, Marcus O. Muench, Jeanfreau R, Olson C, Heather E. Lynch, Matthew J. Spindler, Ashley Gras, Thomas H. Oguin, Emily Benzie, Graham Simmons, Kyle P Carter, Robert C. Edgar, Adam S. Adler, Emma Pearce, Yoong Wearn Lim, Kacy Stadtmiller, Jan Fredrik Simons, Hayley Richardson, Bishal K. Gautam, Renee Leong, Ellen K. Wagner, Angélica V Medina-Cucurella, Adams Ms, Chiang Y, Michael A. Asensio, Anushka T. Ramjag, LaRee Tracy, Brendan Tinsley, Jasmeen Saini, Jackson Leong, Christine V.F. Carrington, Sheila M. Keating, Monroe B, Carina Vingsbo Lundberg, Vishal A. Manickam, Chamow Sm, Büscher D, Nicholas Wayham
Plasma-derived polyclonal antibodies are polyvalent drugs used for many important clinical indications that require modulation of multiple drug targets simultaneously, including emerging infectious disease and transplantation. However, plasma-derived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04b038c76143f6982660b22067931792
https://doi.org/10.1101/2020.08.05.232975
https://doi.org/10.1101/2020.08.05.232975
Autor:
Peter Brams, Robert C. Edgar, Srinivasa Rao Bandi, Rena A. Mizrahi, Jackson Leong, David S. Johnson, Matthew J. Spindler, Adam S. Adler, Michael A. Asensio, Pallavi Tawde, Renee Leong, Daniel Bedinger, Haichun Huang, Matthew Adams
Publikováno v:
mAbs
Deep sequencing and single-chain variable fragment (scFv) yeast display methods are becoming more popular for discovery of therapeutic antibody candidates in mouse B cell repertoires. In this study, we compare a deep sequencing and scFv display metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd7835b09231a0400591ed512801411
http://europepmc.org/articles/PMC5916548
http://europepmc.org/articles/PMC5916548
Autor:
Rena A. Mizrahi, Adam S. Adler, Matthew J. Spindler, Matthew Adams, Michael A. Asensio, Robert C. Edgar, David S. Johnson, Jackson Leong, Renee Leong
Publikováno v:
mAbs
Conventionally, mouse hybridomas or well-plate screening are used to identify therapeutic monoclonal antibody candidates. In this study, we present an alternative to hybridoma-based discovery that combines microfluidics, yeast single-chain variable f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e727bb196e839245e7a15cd8a34cc83
https://doi.org/10.1080/19420862.2017.1371386
https://doi.org/10.1080/19420862.2017.1371386
Autor:
Rena A. Mizrahi, Adam S. Adler, Matthew Adams, Michael A. Asensio, Robert C. Edgar, Jackson Leong, Renee Leong, David Goldblatt, Matthew J. Spindler, David S. Johnson, Lucy Roalfe, Rebecca White
Publikováno v:
mAbs
Affinity-matured, functional anti-pathogen antibodies are present at low frequencies in natural human repertoires. These antibodies are often excellent candidates for therapeutic monoclonal antibodies. However, mining natural human antibody repertoir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d44020c0ad2084ae751c1cc632fd3d02
http://europepmc.org/articles/PMC5680809
http://europepmc.org/articles/PMC5680809