Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Ren-min Liu"'
Autor:
Ai-Ling Sun, Wen-Wen Mu, Yan-Mo Li, Ya-Lei Sun, Peng-Xiao Li, Ren-Min Liu, Jie Yang, Guo-Yun Liu
Publikováno v:
Molecules, Vol 26, Iss 11, p 3243 (2021)
Chemotherapeutic agents, which contain the Michael acceptor, are potent anticancer molecules by promoting intracellular reactive oxygen species (ROS) generation. In this study, we synthesized a panel of PL (piperlongumine) analogs with chlorine attac
Externí odkaz:
https://doaj.org/article/79bf19e78f994dc88a66f3c15def5a73
Publikováno v:
Letters in Drug Design & Discovery. 19:769-777
Background: Isoindoline derivatives exhibit a wide range of biological activities and have attracted considerable attention. However, few studies have been conducted on their antidepressant activity. Objective: Here, we designed and synthesized a ser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62fc67a9e8891662588a812e763fb8ea
https://doi.org/10.2174/1570180819666220301141149
https://doi.org/10.2174/1570180819666220301141149
Publikováno v:
Chemistrybiodiversity. 19(2)
This work deals with the design and synthesis of 18 barbituric acid derivatives bearing 1,3-dimethylbarbituric acid and cinnamic acid scaffolds to find potent anticancer agents. The target molecules were obtained through Knoevenagel condensation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bec2c24b76490a42da4ecfbc11ed5c1
https://pubmed.ncbi.nlm.nih.gov/34931450
https://pubmed.ncbi.nlm.nih.gov/34931450
Autor:
Zhe-Shan Quan, Guangyong Li, Xiao-Jing Li, Li-Chao Wei, Ren-Min Liu, Hui Liu, Kang Lei, Shiben Wang, Xuekun Wang, Jun Li
Publikováno v:
Pharmacological Reports. 71:1244-1252
Background Coumarin and 3,4-dihydroquinolinone nuclei are two heterocyclic rings that are important and widely exploited for the development of bioactive molecules. Here, we designed and synthesized a series of 3,4-dihydroquinolinone and coumarin der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711e84526a230bee213b7875f230d00f
https://doi.org/10.1016/j.pharep.2019.07.011
https://doi.org/10.1016/j.pharep.2019.07.011
Synthesis of 1,3,4-oxadiazole derivatives with anticonvulsant activity and their binding to the GABA
Autor:
Jun Li, Guangyong Li, Kang Lei, Hui Liu, Shiben Wang, Ren-Min Liu, Xuekun Wang, Zhe-Shan Quan
Publikováno v:
European journal of medicinal chemistry. 206
In this study, a series of 1,3,4-oxadiazole derivatives (5a-s, 10a-s, and 16a-d) were designed and synthesized using maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) models, to test the anticonvulsant activity of the target comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::154b42f055b984c40a6d4e034c7bd795
https://pubmed.ncbi.nlm.nih.gov/32798790
https://pubmed.ncbi.nlm.nih.gov/32798790
Publikováno v:
Drug development and industrial pharmacy. 46(6)
Objective: With the aim of surmounting the severe hepatotoxicity induced by antituberculosis drug isoniazid (INH), a novel cocrystal of INH with hepatoprotective nutraceutical syringic acid (SYA), ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3c84f3cfaf5ba24988c699b549efb7
https://pubmed.ncbi.nlm.nih.gov/32366135
https://pubmed.ncbi.nlm.nih.gov/32366135
Publikováno v:
Journal of Crystal Growth. 582:126523
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d8680389c5ede31dedca6f3ad54f16c
https://doi.org/10.1016/j.jcrysgro.2022.126523
https://doi.org/10.1016/j.jcrysgro.2022.126523
Publikováno v:
Journal of Molecular Structure. 1243:130729
Although ethionamide (ETH) has proven highly effective for multidrug-resistant tuberculosis treatment, the severe hepatotoxicity limits the clinical application of ETH, making it still just a second-line drug to cure critical TB patients. In this pap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bab98d51f69427815ea6da8b987d1333
https://doi.org/10.1016/j.molstruc.2021.130729
https://doi.org/10.1016/j.molstruc.2021.130729
Autor:
Shao-Zhen Nie, Ting-Ting Ding, Xiaojing Li, Chang-Qiu Zhao, Cheng-Cheng Qin, Hui Yan, Dan-Di Gao, Ren-Min Liu
A series of P-stereogenic phosphinamides were effectively prepared in 65%–94% yield via coupling of H-P species with amines. Meanwhile, the synthesis of chiral N-phosphinoylimines were explored, which could react with Grignard reagents to afford mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c38472be41e3d208293a80755444e14a
Publikováno v:
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
BACKGROUND As an extracellularly released mediator, high-mobility group box 1 (HMGB1) initiates sterile inflammation following severe trauma. Serum HMGB1 levels correlate well with acute traumatic coagulopathy (ATC) in trauma patients, which is indep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46c37cda27cdf1c1ed75a45e09861eaf
https://doi.org/10.12659/msm.900018
https://doi.org/10.12659/msm.900018