Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Ren-Jang Lin"'
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-5 (2023)
Abstract The branchpoint (BP) motif is an essential intronic element for spliceosomal pre-mRNA splicing. In mammals, its sequence composition, distance to the downstream exon, and number of BPs per 3´ splice site are highly variable, unlike the GT/A
Externí odkaz:
https://doaj.org/article/f68404733ae74cfaa8191a997f79d6ce
Autor:
Martina Cusan, Haifeng Shen, Bo Zhang, Aijun Liao, Lu Yang, Meiling Jin, Mike Fernandez, Prajish Iyer, Yiming Wu, Kevyn Hart, Catherine Gutierrez, Sara Nik, Shondra M. Pruett-Miller, Jeremy Stark, Esther A. Obeng, Teresa V. Bowman, Catherine J. Wu, Ren-Jang Lin, Lili Wang
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 17 (2023)
RNA splicing factor SF3B1 is recurrently mutated in various cancers, particularly in hematologic malignancies. We previously reported that coexpression of Sf3b1 mutation and Atm deletion in B cells, but not either lesion alone, leads to the onset of
Externí odkaz:
https://doaj.org/article/2342ae1271db4cc3a65ea43ea203cc65
Autor:
Xiaoling Wang, Yingjia Wang, He Huang, Buyuan Chen, Xinji Chen, Jianda Hu, Tammy Chang, Ren-Jang Lin, Jiing-Kuan Yee
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93575 (2014)
The development of human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) facilitates in vitro studies of human disease mechanisms, speeds up the process of drug screening, and raises the feasibility of using cell replacement th
Externí odkaz:
https://doaj.org/article/c5c1c4e35de3435f978545385b1409f2
Growing evidence indicates that alternative or aberrant pre-mRNA splicing takes place during the development, progression, and metastasis of breast cancer. However, which splicing changes that might contribute directly to tumorigenesis or cancer prog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e8f7a8b1569a62e13bfb58114399c01
https://doi.org/10.1158/0008-5472.c.6495002
https://doi.org/10.1158/0008-5472.c.6495002
Supplementary Tables S1-S5 from Cell Type and Culture Condition–Dependent Alternative Splicing in Human Breast Cancer Cells Revealed by Splicing-Sensitive Microarrays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c106386c3a86a33c789cd30fb7bb78c
https://doi.org/10.1158/0008-5472.22366118.v1
https://doi.org/10.1158/0008-5472.22366118.v1
Supplementary Figure S1 from Cell Type and Culture Condition–Dependent Alternative Splicing in Human Breast Cancer Cells Revealed by Splicing-Sensitive Microarrays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d432ec59d29ff99f79d0b030918c992
https://doi.org/10.1158/0008-5472.22366121.v1
https://doi.org/10.1158/0008-5472.22366121.v1
Autor:
Jessica S. Kurata, Ren-Jang Lin
Dysregulation of microRNAs (miRNAs) has been associated with a variety of cancers. We previously identified miR-151a as a potential cell fitness-regulating microRNA using a miRNA-targeted CRISPR-Cas9 genetic screen. In this study, we created mutant c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab6cce812173c991034b747e4c641515
https://doi.org/10.1101/2023.01.30.526369
https://doi.org/10.1101/2023.01.30.526369
Autor:
Fusheng Gong, Chao Chen, Ren-Jang Lin, Zhiyong He, Ying Su, Qiang Wang, Jinghui Lin, Jinrong Liao
Publikováno v:
Translational Cancer Research
Background Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are standard treatment for advanced non-small cell lung cancer (NSCLC). However, the emergence of EGFR-TKIs resistance poses a big challenge to the treatment. Although
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c52e58c7649c8b93be181127f8e7896e
http://europepmc.org/articles/PMC8797694
http://europepmc.org/articles/PMC8797694
Publikováno v:
Cancer Management and Research. 11:2129-2138
Background Non-small-cell lung cancer (NSCLC) is a global public health problem, and brain is a common metastatic site in advanced NSCLC. Currently, whole-brain radiotherapy (WBRT) remains a major treatment for brain metastases, while EGFR-tyrosine k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3db2b318e7d69cee200e27075c34df7d
https://doi.org/10.2147/cmar.s184922
https://doi.org/10.2147/cmar.s184922
Autor:
Ren-Jang Lin, Mingli Li, Qiao Liu, Anthony K. N. Chan, Chun-Wei Chen, Xiaobao Xu, Shao-Yuan Wang, Wen-Han Chang, Sheela Pangeni Pokharel, Kazuya Miyashita, Nicole Mattson, Lu Yang, Wei Lu
Publikováno v:
Leukemia. 36(1)
Sphingolipids and their metabolic pathways have been implicated in disease development and therapeutic response; however, the detailed mechanisms remain unclear. Using a sphingolipid network focused CRISPR/Cas9 library screen, we identified an endopl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c9c4cf65e172553fde8dcee7dadc64
https://pubmed.ncbi.nlm.nih.gov/34373586
https://pubmed.ncbi.nlm.nih.gov/34373586