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Carotid-Femoral Pulse Transit Time Variability Predicted Mortality and Improved Risk Stratification in the Elderly

Autor: Peter M. Nilsson, Yan Borné, Chang-Sheng Sheng, Qian-Hui Guo, Margaretha Persson, Yan Li, Ji-Guang Wang, Gunnar Engström, Ming-Xuan Li, Iram Faqir Muhammad, Ren-Zhi Cai, De-Wei An

Publikováno v: Hypertension. 78:1287-1295

The carotid-to-femoral pulse wave velocity, determined by pulse transit time (PTT) and distance, is a well-established measure of arterial stiffness and predicts adverse outcomes. However, its predictive value decreases with aging. To explore new ris

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45ab4bc35eb9ddf493b3a6646226b498
https://doi.org/10.1161/hypertensionaha.121.17891

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A new approach to the treatment of acute myeloid leukaemia targeting the receptor for growth hormone-releasing hormone

Autor: Ren Zhi Cai, Ronan T. Swords, Aymee Perez, Gina M. DelCanto, Petra Popovics, Ailin Vila Granda, Ferenc G. Rick, Andrew V. Schally, Joaquin J. Jimenez, Irving Vidaurre

Publikováno v: British Journal of Haematology. 181:476-485

Growth hormone-releasing hormone (GHRH) is secreted by the hypothalamus and acts on the pituitary gland to stimulate the release of growth hormone (GH). GHRH can also be produced by human cancers, in which it functions as an autocrine/paracrine growt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e2efe36af8e0eca2b5f682eb7591d1
https://doi.org/10.1111/bjh.15207

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New therapeutic approach to heart failure due to myocardial infarction based on targeting growth hormone-releasing hormone receptor

Autor: Joshua M. Hare, Norman L. Block, Marta Zarandi, Luca Szalontay, Ren Zhi Cai, Miklós Jászberényi, Petra Popovics, Rosemeire M. Kanashiro-Takeuchi, Andrew V. Schally, Ferenc G. Rick, Lauro M Takeuchi, Irving Vidaurre

Publikováno v: Oncotarget

// Rosemeire M. Kanashiro-Takeuchi 1, 2, * , Luca Szalontay 3, * , Andrew V. Schally 1, 3, 4, 5, 6 , Lauro M. Takeuchi 1 , Petra Popovics 3, 7, 8 , Miklos Jaszberenyi 3, 4 , Irving Vidaurre 3 , Marta Zarandi 3 , Ren-Zhi Cai 3, 4 , Norman L. Block 1,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb355def90d25a7baef45106b1f2c19
https://doi.org/10.18632/oncotarget.3303

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Suppression of the proliferation of human U-87 MG glioblastoma cells by new antagonists of growth hormone-releasing hormone in vivo and in vitro

Autor: Miklós Jászberényi, Irving Vidaurre, Marta Zarandi, Arumugam R. Jayakumar, Norman L. Block, Andrew V. Schally, Ren Zhi Cai, Luca Szalontay, Ferenc G. Rick

Publikováno v: Targeted Oncology. 8:281-290

Five-year survival of patients afflicted with glioblastoma multiforme (GBM) is rare, making this cancer one of the most feared malignancies. Previously, we reported that growth hormone-releasing hormone (GHRH) is a potent growth factor in cancers. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de664f5ef2739002aec9b33ff596c0d6
https://doi.org/10.1007/s11523-013-0264-y

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Beneficial effects of novel antagonists of GHRH in different models of Alzheimer's disease

Autor: Marta Zarandi, Ren Zhi Cai, Andrew V. Schally, Miklós Jászberényi, Luca Szalontay, Norman L. Block, Ferenc G. Rick

Publikováno v: Aging (Albany NY)

Alzheimer's disease is the most frequent debilitating disorder of the central nervous system. Neuroendocrine mechanisms appear to play an important role in this insidiously developing disease. In the present study, the effects of a recently developed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8519209b65336db21b54a4835f8b8343
https://doi.org/10.18632/aging.100504

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Growth Hormone–Releasing Hormone Agonists Reduce Myocardial Infarct Scar in Swine With Subacute Ischemic Cardiomyopathy

Autor: Samuel Golpanian, Viky Y Suncion, David Valdes, Ren Zhi Cai, Jose Rodriguez, Vasileios Karantalis, Rosemeire M. Kanashiro-Takeuchi, Luiza Bagno, Azorides R. Morales, Marcos Rosado, Andrew V. Schally, Ariel Wolf, Wei Sha, Peter Goldstein, Norman L. Block, Joshua M. Hare, Bo Wang, Wayne Balkan, Courtney Premer

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Background Growth hormone–releasing hormone agonists ( GHRH ‐As) stimulate cardiac repair following myocardial infarction ( MI ) in rats through the activation of the GHRH signaling pathway within the heart. We tested the hypothesis that the admi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd763c1501c69b5ac4190c55fe7e046
http://europepmc.org/articles/PMC4579962

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Inhibition of human androgen-independent PC-3 and DU-145 prostate cancers by antagonists of bombesin and growth hormone releasing hormone is linked to PKC, MAPK and c-jun intracellular signalling

Autor: Anton Stangelberger, Patricia Armatis, Brian D. Hammann, Ren Zhi Cai, Andrew V. Schally, Benjamin Baker, Celia A. Kanashiro, Jozsef L. Varga, Marta Zarandi

Publikováno v: European Journal of Cancer. 41:2735-2744

Bombesin/gastrin-releasing peptide (BN/GRP) antagonists RC-3940-II and RC-3940-Et, and growth hormone-releasing hormone (GHRH) antagonists MZ-J-7-118 and RC-J-29-18 inhibit the growth of human androgen-independent PC-3 and DU-145 prostate cancers in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d039e3b293c53b526d515325664637
https://doi.org/10.1016/j.ejca.2005.08.022

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Antagonists of growth hormone releasing hormone (GHRH) and of bombesin/gastrin releasing peptide (BN/GRP) suppress the expression of VEGF, bFGF, and receptors of the EGF/HER family in PC-3 and DU-145 human androgen-independent prostate cancers

Autor: Anton Stangelberger, Marta Zarandi, Jozsef L. Varga, Kate Groot, Gabor Halmos, Andrew V. Schally, Ren Zhi Cai, Brian D. Hammann

Publikováno v: The Prostate. 64:303-315

BACKGROUND Antagonists of growth hormone releasing hormone (GHRH) as well as antagonists of bombesin/gastrin releasing peptide (BN/GRP) inhibit the growth of various malignancies (cancers) including prostate cancer. METHODS We investigated the effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e306b6973da86a9b6ac24cd5c1f19c8
https://doi.org/10.1002/pros.20262

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Agonists of growth hormone-releasing hormone stimulate self-renewal of cardiac stem cells and promote their survival

Autor: Victoria Florea, Norman L. Block, Joshua M. Hare, Ren Zhi Cai, Sonia S Majid, Andrew V. Schally, Claudia O. Rodrigues, Rosemeire M. Kanashiro-Takeuchi

The beneficial effects of agonists of growth hormone-releasing hormone receptor (GHRH-R) in heart failure models are associated with an increase in the number of ckit(+) cardiac stem cells (CSCs). The goal of the present study was to determine the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0ffe6a30d2c8b074e134f2446917d2
https://europepmc.org/articles/PMC4260571/

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Preclinical efficacy of growth hormone-releasing hormone antagonists for androgen-dependent and castration-resistant human prostate cancer

Autor: Marta Zarandi, Maria I. Garcia, Ferenc G. Rick, Ren Zhi Cai, Andrew V. Schally, Kerry L. Burnstein, Norman L. Block, Cale D. Fahrenholtz

Advanced hormone-sensitive prostate cancer responds to androgen-deprivation therapy (ADT); however, therapeutic options for recurrent castration-resistant disease are limited. Because growth hormone-releasing hormone (GHRH) and GHRH receptor (GHRH-R)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4851490d8e3c33b4db987047d02837ba
https://europepmc.org/articles/PMC3903215/

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